Amoxapine
Depressive Disorder, Psychophysiologic Disorders
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DRUG STATUS
Approvals
US(FDA)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Tricyclic Antidepressant
Amoxapine
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Click HereSummary
Amoxapine is used to treat depression, including neurotic, reactive, and psychotic depressions. It's also used for depression accompanied by anxiety or agitation.
Amoxapine works by increasing the levels of certain natural substances in the brain, such as norepinephrine and serotonin, which help maintain mental balance. It also has a mild sedative effect which can aid in reducing anxiety.
The usual effective dosage for adults is 200 to 300 mg daily, taken orally. For hospitalized patients, the dosage may be increased up to 600 mg daily in divided doses.
Common side effects of Amoxapine include drowsiness, dry mouth, and constipation. Serious adverse effects can include muscle stiffness, confusion, and irregular heartbeat.
Amoxapine should not be used with monoamine oxidase inhibitors. It may increase the risk of suicidality in young adults and cause drowsiness, so caution is advised when driving. Patients with a history of seizures or cardiovascular disorders should use it cautiously.
Indications and Purpose
What is Amoxapine used for?
Amoxapine is indicated for the treatment of depression, including neurotic or reactive depressive disorders, as well as endogenous and psychotic depressions. It is also used for depression accompanied by anxiety or agitation, helping to alleviate symptoms and improve mental balance.
How does Amoxapine work?
Amoxapine works by increasing the levels of norepinephrine and serotonin, natural substances in the brain that help maintain mental balance. It also has a mild sedative effect, which can help reduce anxiety and agitation associated with depression. This action helps alleviate symptoms of depression and improve mood.
Is Amoxapine effective?
Clinical studies have shown that Amoxapine has a more rapid onset of action compared to other antidepressants like amitriptyline or imipramine. The initial clinical effect may occur within four to seven days, with over 80% of responders experiencing effects within two weeks, indicating its effectiveness in treating depression.
How does one know if Amoxapine is working?
The benefit of Amoxapine is evaluated through regular follow-up appointments with a healthcare provider, who will monitor symptoms of depression and any side effects. Patients should report any changes in mood, behavior, or physical health to ensure the medication is working effectively and safely.
Directions for Use
What is the usual dose of Amoxapine?
The usual effective dosage for adults is 200 to 300 mg daily. For hospitalized patients, the dosage may be increased up to 600 mg daily in divided doses. Amoxapine is not recommended for use in children, as its safety and effectiveness have not been established for this age group.
How do I take Amoxapine?
Amoxapine is taken orally, usually once or more times a day, and can be taken with or without food. It is important to take it at the same time each day, preferably at bedtime if taken once daily. There are no specific food restrictions mentioned, but patients should follow their healthcare provider's advice.
For how long do I take Amoxapine?
Amoxapine is typically used for several weeks to months, depending on the individual's response and the severity of their depression. It may take several weeks to feel the full effect, and treatment should continue even if symptoms improve, as advised by a healthcare provider.
How long does it take for Amoxapine to start working?
Amoxapine may start to show initial effects within four to seven days, with most patients experiencing significant improvement within two weeks. However, it may take several weeks to feel the full effect. Patients should continue taking the medication as prescribed and consult their healthcare provider if they have concerns about its effectiveness.
How should I store Amoxapine?
Amoxapine should be stored in its original container, tightly closed, at room temperature away from excess heat and moisture. It should be kept out of reach of children. Unused medication should be disposed of through a take-back program to prevent accidental ingestion by pets or children.
Warnings and Precautions
Who should avoid taking Amoxapine?
Amoxapine is contraindicated in patients with hypersensitivity to dibenzoxazepine compounds and should not be used with monoamine oxidase inhibitors. It may increase the risk of suicidality in young adults and cause drowsiness, so caution is advised when driving. Patients with a history of seizures or cardiovascular disorders should use it cautiously.
Can I take Amoxapine with other prescription drugs?
Amoxapine should not be taken with monoamine oxidase inhibitors due to the risk of severe reactions. It may interact with other medications like cimetidine, which can increase tricyclic antidepressant levels. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Can I take Amoxapine with vitamins or supplements?
There are no specific interactions between Amoxapine and vitamins or supplements mentioned in the provided content. However, patients should inform their healthcare provider about all supplements they are taking to ensure there are no potential interactions that could affect the medication's effectiveness or safety.
Can Amoxapine be taken safely while pregnant?
Amoxapine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as there are no adequate and well-controlled studies in pregnant women. Animal studies have shown embryotoxicity and fetotoxic effects at high doses, so caution is advised when prescribing to pregnant women.
Can Amoxapine be taken safely while breastfeeding?
Amoxapine is excreted in human milk, and its effects on infants are unknown. Therefore, caution should be exercised when administering Amoxapine to nursing women. It is important to discuss the potential risks and benefits with a healthcare provider to determine the best course of action.
Is Amoxapine safe for the elderly?
Elderly patients should use Amoxapine with caution, starting at a lower dose due to increased sensitivity to side effects like sedation and tardive dyskinesia. The recommended starting dose is 25 mg two or three times daily, with careful monitoring and gradual increases if needed. Consult a healthcare provider for personalized advice.
Is it safe to exercise while taking Amoxapine?
Amoxapine may cause drowsiness, fatigue, or dizziness, which could limit your ability to exercise safely. If you experience these side effects, it is important to assess your ability to perform physical activities and consult your healthcare provider for advice on managing these symptoms while maintaining an exercise routine.
Is it safe to drink alcohol while taking Amoxapine?
Drinking alcohol while taking Amoxapine can increase the drowsiness caused by the medication. This can affect your ability to perform tasks that require alertness, such as driving or operating machinery. It is generally advised to avoid alcohol while taking Amoxapine to prevent these effects and ensure the medication works effectively.