Alfuzosin
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
N/A
Pharmaceutical Class
Alpha-Adrenergic Blocker
Alfuzosin
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Click HereSummary
Alfuzosin is a medication used to treat the symptoms of an enlarged prostate in adult men. It is not intended for use by women or children.
Alfuzosin works by relaxing the muscles around the bladder and prostate, which helps urine flow more easily. It does not typically affect weight, appetite, or eating behaviors.
Alfuzosin is typically administered as extended-release tablets taken with food and the same meal each day. The tablets should not be crushed or chewed as they are designed to release the medication slowly over time.
Common side effects of Alfuzosin include dizziness, headaches, and fatigue. Other side effects include upper respiratory tract infection, abdominal pain, and nausea. Serious side effects include a sudden drop in blood pressure and a painful, long-lasting erection known as priapism.
Alfuzosin can lower blood pressure, especially when first taken, which could cause dizziness or fainting. It should not be taken if you have liver problems, are taking certain antifungal or anti-HIV medicines, or are allergic to Alfuzosin. It is important to avoid driving or operating machinery until you know how Alfuzosin affects you.
Indications and Purpose
What is Alfuzosin used for?
Alfuzosin is indicated for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH) in adult men. It is not indicated for the treatment of hypertension or for use in the pediatric population.
How does Alfuzosin work?
Alfuzosin works by selectively blocking post-synaptic alpha1-adrenoreceptors in the prostate and bladder neck. This action relaxes the smooth muscles in these areas, improving urine flow and reducing symptoms of benign prostatic hyperplasia (BPH). It does not significantly affect blood pressure.
Is Alfuzosin effective?
Alfuzosin has been shown to effectively reduce symptoms of benign prostatic hyperplasia (BPH) in clinical trials. In three randomized, placebo-controlled trials, alfuzosin significantly reduced the International Prostate Symptom Score (IPSS) and increased peak urinary flow rate compared to placebo, indicating its effectiveness in treating BPH symptoms.
How does one know if Alfuzosin is working?
The benefit of alfuzosin is evaluated through its ability to reduce symptoms of benign prostatic hyperplasia (BPH), as measured by the International Prostate Symptom Score (IPSS) and improvements in peak urinary flow rate. Regular follow-ups with a healthcare provider can help assess the effectiveness of the treatment.
Directions for Use
What is the usual dose of Alfuzosin?
The usual daily dose for adults is one 10 mg alfuzosin hydrochloride extended-release tablet taken once daily. Alfuzosin is not indicated for use in children.
How do I take Alfuzosin?
Take alfuzosin hydrochloride extended-release tablets with food, ideally with the same meal each day. Do not take it on an empty stomach, as absorption is reduced. Swallow the tablet whole without crushing or chewing. There are no specific food restrictions, but consistency in meal timing is important.
For how long do I take Alfuzosin?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
How long does it take for Alfuzosin to start working?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
How should I store Alfuzosin?
Store alfuzosin hydrochloride extended-release tablets at room temperature, between 59°F and 86°F (15°C and 30°C). Protect the tablets from light and moisture, and keep them out of reach of children. Ensure they are stored in a tight, light-resistant container.
Warnings and Precautions
Who should avoid taking Alfuzosin?
Alfuzosin is contraindicated in patients with moderate or severe hepatic impairment and those taking potent CYP3A4 inhibitors like ketoconazole. It may cause postural hypotension, so caution is advised when used with antihypertensive medications. Patients should be screened for prostate cancer before starting treatment, as BPH and prostate cancer can have similar symptoms.
Can I take Alfuzosin with other prescription drugs?
Alfuzosin should not be used with potent CYP3A4 inhibitors like ketoconazole, itraconazole, or ritonavir, as these can increase alfuzosin blood levels. Caution is advised when used with antihypertensive medications and nitrates due to the risk of hypotension. It should not be combined with other alpha-adrenergic antagonists.
Can I take Alfuzosin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Alfuzosin be taken safely while pregnant?
Alfuzosin is not indicated for use in women, including during pregnancy. There are no adequate data on the developmental risk associated with its use in pregnant women. Animal studies have not shown teratogenic effects, but the relevance to human pregnancy is unknown. Consult a healthcare provider for advice.
Can Alfuzosin be taken safely while breastfeeding?
Alfuzosin is not indicated for use in women, including those who are breastfeeding. There is no data on the presence of alfuzosin in human milk or its effects on the breastfed child or milk production. Consult a healthcare provider for personalized advice.
Is Alfuzosin safe for the elderly?
In clinical studies, 48% of subjects were 65 years or older, and 11% were 75 and older. No overall differences in safety or effectiveness were observed between these subjects and younger ones. However, greater sensitivity in some older individuals cannot be ruled out. Elderly patients should be monitored closely for side effects.
Is it safe to exercise while taking Alfuzosin?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Alfuzosin?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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