Aceclofenac

Ipca Laboratories Ltd ,

Mankind Pharma Ltd

Zerodol 200mg Tablet CR 10s ,

Dolokind 100mg Tablet 10s

DRUG STATUS

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Approvals

US. FDA / uk mhra / ema / pdma

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Essential Medicine

WHO / India

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Use in Pregnancy

Not Advised / Caution

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Pharmaceutical Class

ama / pdma

Summary

  • Aceclofenac is used to treat pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used for dental pain and postoperative pain.

  • Aceclofenac works by blocking enzymes called cyclooxygenase (COX), which are involved in making chemicals called prostaglandins. These chemicals cause pain, fever, and inflammation. By reducing their production, Aceclofenac helps to alleviate these symptoms and improve joint mobility.

  • The usual dosage for adults is 100 mg of Aceclofenac taken twice daily with meals. The tablets should be swallowed whole with water, not chewed or crushed.

  • Common side effects include stomach upset, nausea, dizziness, and headache. Serious side effects can include gastrointestinal bleeding, ulcers, liver dysfunction, and kidney problems. Allergic reactions such as rash and swelling may also occur.

  • Aceclofenac should be avoided by individuals with a history of gastrointestinal ulcers, bleeding disorders, or kidney or liver disease. It is also not recommended for patients with severe heart failure or those allergic to NSAIDs. Caution is advised for people with hypertension, asthma or cardiovascular disease. It should be used with care in pregnancy and lactation.

Indications and Purpose

How does Aceclofenac work?

Aceclofenac works by inhibiting the action of cyclooxygenase (COX) enzymes, primarily COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing the production of these substances, Aceclofenac helps alleviate pain, reduce inflammation, and improve mobility in conditions like arthritis and musculoskeletal disorders.

 

 

How does one know if Aceclofenac is working?

The effectiveness of Aceclofenac is evaluated through clinical assessments that measure pain relief, reduction in inflammation, and improvement in joint function. This can include patient-reported outcomes, such as a reduction in pain intensity on a scale, and increased mobility or functionality. Additionally, healthcare providers may monitor physical examination findings and use imaging techniques to assess improvements in conditions like arthritis.

 

 

Is Aceclofenac effective?

Studies have shown that Aceclofenac effectively reduces pain, inflammation, and stiffness in patients with conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Clinical trials demonstrate that it significantly improves joint function and mobility while being well-tolerated. Its efficacy in managing acute pain, such as dental or postoperative pain, has also been established through research.

 

 

What is Aceclofenac used for?

Aceclofenac is used to treat pain and inflammation caused by conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and musculoskeletal pain. It is also effective for managing dental pain and postoperative pain. By inhibiting cyclooxygenase (COX) enzymes, Aceclofenac reduces the production of prostaglandins, helping to relieve pain and inflammation and improve joint mobility.

 

 

Directions for Use

How do I take Aceclofenac?

Aceclofenac should be taken with food to minimize the risk of stomach irritation. There are no specific food restrictions while using this medication, but it is advisable to avoid excessive alcohol consumption, as it may increase the risk of gastrointestinal side effects. Always follow your doctor's advice regarding dosage and any specific dietary guidelines.

 

 

How long does it take for Aceclofenac to start working?

Aceclofenac typically starts working within 30 minutes to 1 hour after taking it. However, the full therapeutic effect may take a few days to become noticeable, especially for conditions like arthritis. The medication helps reduce pain, inflammation, and stiffness gradually as it works to inhibit the production of inflammatory chemicals in the body.

 

 

How should I dispose of Aceclofenac?

If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of the medicines properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.

How should I store Aceclofenac?

Aceclofenac should be stored at room temperature, away from direct light and moisture. Keep it in a dry place, preferably in its original packaging, and out of reach of children. Do not store it in the bathroom or near sources of heat. Always check the expiration date before use, and dispose of expired medication properly.

 

 

What are the consequences to stopping Aceclofenac?

Stopping Aceclofenac suddenly, especially after long-term use, can lead to a return of pain and inflammation associated with the underlying condition (e.g., arthritis). If you need to stop it, it's best to consult your doctor first. They may recommend tapering off the medication to reduce potential withdrawal symptoms or flare-ups of your condition.

 

 

What is Aceclofenac’s dose and duration?

For adults, the usual dosage of Aceclofenac is 100 mg taken twice daily, with meals, to reduce the risk of stomach irritation. The tablets should be swallowed whole with water and not chewed or crushed. Aceclofenac should be used at the lowest effective dose for the shortest duration to minimize the risk of side effects. Always follow a doctor's instructions.

 

 

What should I do if I miss a dose of Aceclofenac?

If you forget to take one or more doses: take your next dose at the normal time and in the normal amount. Do not take any more than your doctor prescribed.

Warnings and Precautions

Can Aceclofenac be taken safely while breastfeeding?

Aceclofenac is not recommended during breastfeeding, as it may pass into breast milk and could potentially harm the infant. While there is limited data on its effects during lactation, due to the risks of side effects such as gastrointestinal irritation or renal effects, it is advisable to avoid using Aceclofenac while breastfeeding. Consult a healthcare provider for alternatives.

 

 

Can Aceclofenac be taken safely while pregnant?

Aceclofenac is generally not recommended during pregnancy, especially in the third trimester, due to the potential for fetal harm, including premature closure of the ductus arteriosus, a vital blood vessel in the fetus. It may also increase the risk of kidney problems and bleeding in the mother and baby. Always consult a doctor before using it during pregnancy.

 

 

Can Aceclofenac be taken safely while trying to conceive?

Aceclofenac may have a temporary effect on fertility in both men and women. It can impair ovulation in women by affecting prostaglandin synthesis, which plays a role in reproductive processes. In men, long-term use of NSAIDs like Aceclofenac may impact sperm production. If planning pregnancy, it's advisable to consult a healthcare provider before using this medication.

 

 

Can I take Aceclofenac with other prescription drugs?

Aceclofenac may interact with anticoagulants (e.g., warfarin) increasing bleeding risk, other NSAIDs raising gastrointestinal risks, antihypertensives (e.g., ACE inhibitors) reducing blood pressure control, lithium causing toxicity, and corticosteroids enhancing gastrointestinal bleeding risks. It’s important to consult a healthcare provider before combining Aceclofenac with other medications to avoid adverse interactions.

 

 

Can I take Aceclofenac with vitamins or supplements?

Aceclofenac may interact with certain vitamins or supplements, particularly vitamin K (which can affect blood clotting) and antioxidants like vitamin C or E, which could potentially alter its anti-inflammatory effects. Omega-3 fatty acids and garlic supplements may increase the risk of gastrointestinal bleeding when taken with Aceclofenac. Always consult a healthcare provider before combining supplements with this medication.

 

 

What are Aceclofenac possible harms and risks?

Common side effects of Aceclofenac include stomach upset, nausea, dizziness, and headache. Serious adverse effects can include gastrointestinal bleeding, ulcers, liver dysfunction, and kidney problems. Allergic reactions, such as rash and swelling, may also occur. Long-term use can increase the risk of heart attacks or stroke,

 

 

Who should avoid taking Aceclofenac?

Aceclofenac should be avoided by individuals with a history of gastrointestinal ulcers, bleeding disorders, or kidney or liver disease. It is contraindicated in patients with severe heart failure or allergic reactions to NSAIDs. Caution is advised for people with hypertension, asthma, or cardiovascular disease. It should be used with care in pregnancy and lactation, particularly in the third trimester.

 

 

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