Zaleplon
Sleep Initiation and Maintenance Disorders
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Gamma-Aminobutyric Acid A Receptor Agonist
Controlled Drug Substance
NO
Zaleplon
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Click HereSummary
Zaleplon is a medication primarily used for the short-term treatment of insomnia, particularly to help individuals who have difficulty falling asleep.
Zaleplon works by interacting with the GABABZ receptor complex in the brain, which enhances the effects of the neurotransmitter GABA. This action slows down brain activity, helping to induce sleep.
The usual dose of Zaleplon for adults is 10 mg, taken orally immediately before bedtime. For certain low-weight individuals, a 5 mg dose may be sufficient. It is not recommended for children.
Common side effects of Zaleplon include drowsiness, dizziness, and headache. Serious adverse effects can include complex sleep behaviors like sleep-driving and severe allergic reactions.
Zaleplon may cause complex sleep behaviors, which can be dangerous. It should not be used with alcohol or other CNS depressants. It is also not recommended for those with severe liver impairment, pregnant women, or nursing mothers.
Indications and Purpose
How does one know if Zaleplon is working?
The benefit of Zaleplon is evaluated by its ability to reduce the time it takes to fall asleep. If sleep problems persist or worsen after 7 to 10 days of use, it may indicate an underlying condition, and a doctor should be consulted for further evaluation.
How does Zaleplon work?
Zaleplon is a hypnotic that interacts with the GABA-BZ receptor complex in the brain, enhancing the effects of the neurotransmitter GABA. This action slows down brain activity, helping to induce sleep.
Is Zaleplon effective?
Clinical trials have shown that Zaleplon is effective in reducing the time it takes to fall asleep. It has been studied in both non-elderly and elderly patients with chronic insomnia, demonstrating a reduction in sleep latency. However, it does not increase total sleep time or reduce awakenings.
What is Zaleplon?
Zaleplon is a sedative-hypnotic medication used for the short-term treatment of insomnia, specifically to help with falling asleep. It works by slowing down brain activity, allowing for sleep. It is not effective for maintaining sleep or reducing nighttime awakenings.
What is Zaleplon used for?
Zaleplon is indicated for the short-term treatment of insomnia, specifically for individuals who have difficulty falling asleep. It is not intended for long-term use or for treating other sleep-related issues like frequent awakenings or early morning awakenings.
Directions for Use
For how long do I take Zaleplon?
Zaleplon is typically prescribed for short-term use, generally not exceeding 7 to 10 days. If sleep problems persist beyond this period, it is important to consult a doctor as it may indicate an underlying condition.
How do I take Zaleplon?
Zaleplon should be taken immediately before bedtime or after going to bed if you have trouble falling asleep. It should not be taken with or immediately after a high-fat meal, as this can delay its absorption and effectiveness. Follow your doctor's instructions carefully.
How long does it take for Zaleplon to start working?
Zaleplon is rapidly absorbed and typically starts working within about 1 hour after oral administration, helping to reduce the time it takes to fall asleep.
How should I store Zaleplon?
Zaleplon should be stored at room temperature, between 68° and 77°F (20° to 25°C), and protected from light. Keep it in its original container, tightly closed, and out of reach of children to prevent accidental ingestion.
What is the usual dose of Zaleplon?
The usual dose of Zaleplon for adults is 10 mg taken immediately before bedtime. For certain low-weight individuals, a 5 mg dose may be sufficient. Zaleplon is not recommended for children as its safety and effectiveness have not been established in pediatric patients.
Warnings and Precautions
Can I take Zaleplon with other prescription drugs?
Zaleplon can interact with other CNS depressants like benzodiazepines, opioids, and alcohol, increasing the risk of sedation and complex sleep behaviors. Cimetidine can increase Zaleplon levels, requiring a lower dose. Always inform your doctor about all medications you are taking.
Can Zaleplon be taken safely while breastfeeding?
Zaleplon is excreted in breast milk, and its effects on a nursing infant are not known. Therefore, it is recommended that nursing mothers avoid taking Zaleplon to prevent potential harm to the infant.
Can Zaleplon be taken safely while pregnant?
Zaleplon is not recommended for use during pregnancy as there are no adequate studies in pregnant women. The potential risks to the fetus are unknown, so it is important to consult a healthcare provider to weigh the benefits and risks.
Is it safe to drink alcohol while taking Zaleplon?
Drinking alcohol while taking Zaleplon can increase the risk of serious side effects, including complex sleep behaviors like sleep-driving. Alcohol can also enhance the sedative effects of Zaleplon, leading to increased drowsiness and impaired coordination. It is advised not to drink alcohol while taking this medication.
Is it safe to exercise while taking Zaleplon?
Zaleplon may cause drowsiness and decreased mental alertness, which could affect physical coordination and reaction time. It is advisable to avoid exercise or activities requiring full alertness until you know how Zaleplon affects you.
Is Zaleplon safe for the elderly?
Elderly patients are more sensitive to the effects of Zaleplon and should start with a lower dose of 5 mg. They should be monitored closely for side effects such as dizziness and drowsiness, which increase the risk of falls. It is important to use the lowest effective dose.
Who should avoid taking Zaleplon?
Zaleplon may cause complex sleep behaviors like sleep-driving, which can be dangerous. It should not be used with alcohol or other CNS depressants. People with a history of complex sleep behaviors or allergic reactions to Zaleplon should avoid it. It is also not recommended for those with severe liver impairment.
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