Venlafaxine
Depressive Disorder, Pain ... show more
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Serotonin and Norepinephrine Reuptake Inhibitor
Controlled Drug Substance
No

Venlafaxine
Summary
Venlafaxine is primarily used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder. It is also used off-label for posttraumatic stress disorder.
Venlafaxine works by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain. This helps to improve mood, reduce anxiety, and alleviate depressive symptoms.
Venlafaxine is typically started at 75 mg per day for depression, and for anxiety disorders, it may increase to 225 mg. It's taken orally, usually once daily, with food.
Common side effects include nausea, dry mouth, dizziness, insomnia, and sweating. More serious effects can include increased blood pressure, sexual dysfunction, weight changes, and serotonin syndrome.
Venlafaxine should be used with caution in individuals with high blood pressure, seizures, heart disease, or suicidal thoughts. It should not be used by people with hypersensitivity to the drug or monoamine oxidase inhibitors. Abrupt discontinuation can cause withdrawal symptoms.
Indications and Purpose
How does Venlafaxine work?
Venlafaxine works by increasing the levels of two neurotransmitters in the brain: serotonin and norepinephrine. It is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). By blocking the reuptake of these neurotransmitters, venlafaxine helps improve mood, reduce anxiety, and alleviate depressive symptoms. In higher doses, it also inhibits the reuptake of dopamine. This mechanism of action helps regulate mood, anxiety, and stress responses.
Is Venlafaxine effective?
Venlafaxine is proven effective in treating depression, anxiety, and panic disorders by increasing serotonin and norepinephrine levels. Clinical studies show it improves symptoms, especially in severe cases, and is more effective than some other antidepressants.
What is Venlafaxine?
Venlafaxine is commonly used to treat depression, anxiety disorders, and panic disorders. It works by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain, which help regulate mood, anxiety, and stress responses. By balancing these chemicals, venlafaxine can improve mood and reduce symptoms of anxiety and depression. It is typically prescribed as an extended-release tablet taken once daily.
Directions for Use
For how long do I take Venlafaxine?
Venlafaxine is typically used for 6-12 months for most conditions, with longer use for recurrent or chronic cases. Duration depends on the individual’s needs, and tapering off should always be done under medical guidance.
How do I dispose of Venlafaxine?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Venlafaxine?
Venlafaxine should be taken with food to reduce the risk of stomach upset. It is important to swallow the extended-release capsule whole without crushing or chewing. There are no specific food restrictions, but avoiding alcohol is recommended, as it may increase the risk of side effects. Always follow the doctor’s instructions for dosage and usage.
How long does it take for Venlafaxine to start working?
Venlafaxine typically starts showing effects after 1 to 2 weeks of use, but it may take 4 to 6 weeks to experience the full therapeutic benefits, especially for conditions like depression or anxiety. Individual responses can vary, so it's important to follow the prescribed treatment plan and consult a doctor if there's no improvement.
How should I store Venlafaxine?
Keep the medicine in its original container at room temperature between 59°F and 86°F (15°C and 30°C). Make sure the container is tightly closed to prevent moisture or air from getting inside.
What is the usual dose of Venlafaxine?
The medicine starts at a low dose of 75 mg once a day with food. The doctor might increase the dose slowly, by no more than 75 mg every four days, to a maximum of 225 mg daily. Some people might begin with a smaller dose of 37.5 mg for a few days before going up to 75 mg. This information is only for adults.
Warnings and Precautions
Can I take Venlafaxine with other prescription drugs?
Venlafaxine can interact with several prescription medications, including:
- Monoamine oxidase inhibitors (MAOIs): Combining venlafaxine with MAOIs can cause a dangerous condition called serotonin syndrome.
- Other antidepressants (SSRIs, SNRIs, tricyclics): Increased risk of serotonin syndrome and enhanced side effects.
- Antiplatelet drugs/NSAIDs: May increase the risk of bleeding.
- Cimetidine: Can raise venlafaxine levels, increasing the risk of side effects.
- Antihypertensive medications: Venlafaxine may reduce the effectiveness of blood pressure medications.
Can Venlafaxine be taken safely while breastfeeding?
Venlafaxine is excreted in breast milk, but the effects on a nursing infant are not fully known. Studies suggest that the medication may pose a risk of side effects in the infant, such as drowsiness, poor feeding, and irritability. Due to potential risks, breastfeeding mothers should discuss the use of venlafaxine with their healthcare provider to weigh the benefits and risks.
Can Venlafaxine be taken safely while pregnant?
Venlafaxine is classified as a Category C medication during pregnancy, meaning risk to the fetus cannot be ruled out. Studies in animals have shown adverse effects, but there are no well-controlled studies in humans. It should only be used during pregnancy if the potential benefits outweigh the risks. Venlafaxine use during pregnancy, especially in the third trimester, may increase the risk of complications such as preterm birth, low birth weight, and withdrawal symptoms in newborns. Always consult a doctor before using it during pregnancy.
Does Venlafaxine have adverse effects?
Adverse effects, which are unwanted or harmful reactions to a medicine, can occur with any medication. For this medicine, common adverse effects might include nausea, headache, dizziness, fatigue, and dry mouth. These effects can vary in how often they occur, but they are generally not severe. However, there are rare but serious adverse effects that require immediate medical attention, such as difficulty breathing, severe rash, or swelling of the face and throat. It's crucial to report any new or worsening symptoms to a healthcare provider. Never stop taking a medicine without consulting a healthcare professional, as they can provide guidance on managing side effects or adjusting treatment.
Does Venlafaxine have any safety warnings?
To determine if a medicine has safety warnings, you should first check the prescription information provided with the medicine. This information often includes a section on warnings and precautions. For example, if a medicine has a warning about causing drowsiness, the rationale is that it can affect your ability to drive or operate machinery safely. The possible consequence is an increased risk of accidents. Symptoms to monitor include feeling unusually sleepy or having trouble staying alert. Another common warning might be about allergic reactions, which can occur if you are sensitive to the medicine. The rationale is to prevent severe reactions that could be life-threatening. Signs to watch for include rash, itching, swelling, or difficulty breathing. Always consult your healthcare provider for personalized advice and to understand all potential warnings related to your specific medication.
Is it safe to drink alcohol while taking Venlafaxine?
Venlafaxine is a medicine. Mixing it with alcohol can make serious side effects more likely. It's best to avoid alcohol completely while you're taking this medication.
Is it safe to exercise while taking Venlafaxine?
The information regarding any specific interactions between exercise and venlafaxine is not found.
Is it safe to stop Venlafaxine?
To determine if it's safe to stop a medicine, first identify its purpose. If it's for managing a chronic condition like hypertension or diabetes, stopping it suddenly can lead to serious health risks, such as uncontrolled blood pressure or blood sugar levels. For medicines providing symptomatic relief or treating temporary conditions, stopping might lead to the return of symptoms or incomplete treatment of the condition. Some medicines can cause withdrawal symptoms or rebound effects, where symptoms return worse than before. Abruptly stopping certain medicines can be life-threatening, especially those affecting the heart or brain. Always consult a doctor before stopping any medicine to ensure it's done safely and appropriately.
Is Venlafaxine addictive?
This medicine does not have any known potential for dependence or addiction. It is considered safe in terms of habit-forming properties. Therefore, there is no need to worry about developing a physical or psychological dependence on this medication. However, it is always important to use any medication as directed by a healthcare professional to ensure safety and effectiveness. If you have any concerns or questions about your medication, it is best to discuss them with your doctor or pharmacist.
Is Venlafaxine safe for the elderly?
Older people don't usually need a lower dose of venlafaxine just because of their age. However, if they have high blood pressure or liver problems, and they're also taking cimetidine, doctors need to be extra careful because the combination might cause more side effects. Older people also have a slightly higher chance of developing low sodium levels in their blood while taking this medicine. Otherwise, venlafaxine seems to work and be safe similarly in older and younger people.
What are the most common side effects of Venlafaxine?
A side effect is an unwanted or unexpected symptom caused by a medicine. For this medicine, common side effects may include nausea, which is feeling sick to your stomach, dizziness, which is feeling lightheaded or unsteady, headache, which is pain in the head, fatigue, which is feeling very tired, and dry mouth, which is a lack of saliva. The frequency of these side effects can vary, but they are generally considered common. It's important to note that when starting a new medicine, people might experience new symptoms that could be coincidental, unrelated, or temporary. These symptoms might also be due to another health issue. Always talk to a healthcare provider before stopping any medicine, as they can provide guidance on managing side effects and ensure your treatment is safe and effective.
Who should avoid taking Venlafaxine?
Venlafaxine should be used with caution in individuals with a history of high blood pressure, as it can increase blood pressure. It is contraindicated in people with hypersensitivity to the drug or monoamine oxidase inhibitors (MAOIs). Caution is also needed for those with a history of seizures, heart disease, or suicidal thoughts. Abrupt discontinuation can cause withdrawal symptoms.