Vandetanib
Thyroid Neoplasms
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Vandetanib
Summary
Vandetanib is used to treat medullary thyroid cancer that cannot be surgically removed or has spread to other parts of the body.
Vandetanib is a kinase inhibitor. It blocks abnormal proteins that signal cancer cells to multiply, helping to slow or stop the spread of cancer cells.
For adults, the usual daily dose of Vandetanib is 300 mg taken orally once daily. For children, the dosage is based on body surface area and should be determined by a healthcare provider.
Common side effects of Vandetanib include diarrhea, rash, nausea, hypertension, and headache. Serious adverse effects can include QT prolongation, severe skin reactions, and interstitial lung disease.
Vandetanib can cause QT prolongation leading to serious heart issues. It's contraindicated in patients with long QT syndrome or electrolyte imbalances. Regular monitoring of heart function and electrolytes is essential. Avoid using with other QT-prolonging drugs.
Indications and Purpose
How does Vandetanib work?
Vandetanib is a kinase inhibitor that blocks the action of abnormal proteins that signal cancer cells to multiply. By inhibiting these proteins, it helps slow or stop the spread of cancer cells, particularly in medullary thyroid cancer.
Is Vandetanib effective?
Vandetanib is proven effective in treating medullary thyroid cancer that cannot be surgically removed or has spread. Clinical trials have shown it improves progression-free survival and reduces tumor growth by blocking proteins that signal cancer cells to multiply.
What is Vandetanib?
Vandetanib is used to treat medullary thyroid cancer that cannot be surgically removed or has spread. It works by blocking proteins that signal cancer cells to multiply, slowing or stopping the spread of cancer. Regular monitoring is essential to manage potential side effects.
Directions for Use
For how long do I take Vandetanib?
Vandetanib is typically used until the disease progresses or until unacceptable toxicity occurs. The duration of use can vary based on individual response and side effects, so it's important to follow your doctor's guidance.
How do I take Vandetanib?
Take Vandetanib once daily, with or without food, at the same time each day. Swallow the tablets whole with water. If you cannot swallow them, dissolve in water as instructed. There are no specific food restrictions, but follow your doctor's advice.
How long does it take for Vandetanib to start working?
Vandetanib may take several weeks to show its effects, as it works by gradually slowing or stopping the growth of cancer cells. Regular monitoring by your doctor will help assess its effectiveness over time.
How should I store Vandetanib?
Store Vandetanib in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Vandetanib?
For adults, the usual daily dose of Vandetanib is 300 mg taken orally once daily. For children, the dosage is based on body surface area (BSA) and should be determined by a healthcare provider. It's important to follow the doctor's instructions carefully.
Warnings and Precautions
Can I take Vandetanib with other prescription drugs?
Vandetanib interacts with drugs that prolong the QT interval, such as certain antiarrhythmics and antibiotics. It also interacts with CYP3A4 inducers like rifampicin, which can reduce its effectiveness. Inform your doctor of all medications you're taking to avoid interactions.
Can Vandetanib be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Vandetanib and for 4 months after the last dose due to the potential for serious adverse reactions in breastfed children. Consult your doctor for advice on feeding options.
Can Vandetanib be taken safely while pregnant?
Vandetanib can cause fetal harm and is not recommended during pregnancy. Women of childbearing potential should use effective contraception during treatment and for at least 4 months after the last dose. If you become pregnant, inform your doctor immediately.
Is it safe to exercise while taking Vandetanib?
Vandetanib may cause fatigue, weakness, and other side effects that could limit your ability to exercise. If you experience these symptoms, it's important to discuss them with your doctor, who can provide guidance on safe levels of physical activity.
Is Vandetanib safe for the elderly?
There is limited data on the use of Vandetanib in patients over 75 years old. Elderly patients may be more susceptible to side effects, so careful monitoring and dose adjustments may be necessary. It's important for elderly patients to follow their doctor's guidance closely.
Who should avoid taking Vandetanib?
Vandetanib can cause QT prolongation, leading to serious heart issues. It's contraindicated in patients with long QT syndrome or electrolyte imbalances. Regular monitoring of heart function and electrolytes is essential. Avoid using with other QT-prolonging drugs.
