Valbenazine
Tardive Dyskinesia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Vesicular Monoamine Transporter 2 Inhibitor
Controlled Drug Substance
No
Valbenazine
Summary
Valbenazine is used to treat tardive dyskinesia, a condition involving uncontrollable movements of the face, tongue, or other body parts. It's also used for chorea associated with Huntington's disease, which causes sudden involuntary movements.
Valbenazine works by inhibiting a protein called vesicular monoamine transporter 2 (VMAT2). This protein helps regulate neurotransmitter levels in the brain, which in turn reduces involuntary movements.
The usual starting dose for adults is 40 mg once daily, which can be increased to 80 mg once daily based on response and tolerability. Valbenazine is taken orally, with or without food.
Common side effects include sleepiness, tiredness, nausea, vomiting, and diarrhea. Less common but serious adverse effects can include depression, suicidal thoughts, and hypersensitivity reactions.
Valbenazine can increase the risk of depression and suicidal thoughts, especially in patients with Huntington's disease. It can also cause drowsiness, QT prolongation, and hypersensitivity reactions. Patients with a history of depression or heart issues should use it cautiously.
Indications and Purpose
How does Valbenazine work?
Valbenazine works by inhibiting the vesicular monoamine transporter 2 (VMAT2), a protein that regulates the uptake of neurotransmitters into synaptic vesicles. This action helps reduce the excessive movements associated with conditions like tardive dyskinesia and Huntington's disease.
Is Valbenazine effective?
Valbenazine's effectiveness has been demonstrated in clinical trials for treating tardive dyskinesia and chorea associated with Huntington's disease. In these studies, patients showed significant improvement in involuntary movements compared to those receiving a placebo. Always consult your doctor for more detailed information.
What is Valbenazine?
Valbenazine is used to treat tardive dyskinesia and chorea associated with Huntington's disease. It works by inhibiting the vesicular monoamine transporter 2 (VMAT2), which helps regulate neurotransmitter levels in the brain, reducing involuntary movements. Always follow your doctor's instructions when using this medication.
Directions for Use
For how long do I take Valbenazine?
The duration of Valbenazine use depends on the individual's condition and response to treatment. It is typically used as a long-term treatment for conditions like tardive dyskinesia and chorea associated with Huntington's disease. Always follow your doctor's guidance on how long to take this medication.
How do I take Valbenazine?
Valbenazine should be taken once daily, with or without food, at the same time each day. There are no specific food restrictions, but it's important to follow your doctor's instructions and not to take more or less than prescribed.
How long does it take for Valbenazine to start working?
Valbenazine may start to show effects within a few weeks, but it can take longer for some individuals to notice significant improvements. It's important to continue taking the medication as prescribed and consult your doctor if you have concerns about its effectiveness.
How should I store Valbenazine?
Store Valbenazine at room temperature, between 15°C to 30°C (59°F to 86°F). Keep it in its original container, tightly closed, and away from excess heat and moisture. Ensure it is out of reach of children and pets to prevent accidental ingestion.
What is the usual dose of Valbenazine?
For adults, the usual starting dose of Valbenazine is 40 mg once daily, which can be increased to 80 mg once daily based on response and tolerability. The safety and effectiveness of Valbenazine in children have not been established, so it is not typically prescribed for pediatric use.
Warnings and Precautions
Can I take Valbenazine with other prescription drugs?
Valbenazine can interact with monoamine oxidase inhibitors (MAOIs), strong CYP3A4 inhibitors, and strong CYP2D6 inhibitors, which can affect its effectiveness and increase side effects. Always inform your doctor about all medications you are taking to avoid potential interactions.
Can Valbenazine be taken safely while breastfeeding?
It is not known if Valbenazine passes into breast milk. Due to potential risks to the infant, it is advised not to breastfeed during treatment and for 5 days after the final dose. Consult your doctor for personalized advice on feeding your baby while on this medication.
Can Valbenazine be taken safely while pregnant?
There is limited data on the use of Valbenazine during pregnancy, and its effects on the fetus are not well established. Animal studies have shown potential risks, so it's important to discuss with your doctor if you are pregnant or planning to become pregnant while taking this medication.
Is it safe to drink alcohol while taking Valbenazine?
Drinking alcohol while taking Valbenazine can increase drowsiness and tiredness, which are side effects of the medication. It is advised to avoid alcohol to prevent these effects from becoming more pronounced and to ensure safety, especially when performing tasks that require alertness.
Is it safe to exercise while taking Valbenazine?
Valbenazine may cause drowsiness and tiredness, which could affect your ability to exercise. If you feel too tired or sleepy, it might be best to avoid strenuous activities. Consult your doctor for advice tailored to your situation.
Is Valbenazine safe for the elderly?
No specific dose adjustment is required for elderly patients taking Valbenazine. However, as with any medication, elderly patients should be monitored closely for side effects, especially those related to drowsiness and cognitive changes. Consult a healthcare provider for personalized advice.
Who should avoid taking Valbenazine?
Valbenazine may increase the risk of depression and suicidal thoughts, especially in patients with Huntington's disease. It can also cause drowsiness, QT prolongation, and hypersensitivity reactions. Patients with a history of depression or heart issues should use it cautiously. Always inform your doctor of your medical history before starting Valbenazine.
