Ulipristal acetate
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Progesterone Agonist/Antagonist
Controlled Drug Substance
No
Ulipristal acetate
Summary
Ulipristal acetate is used primarily for emergency contraception, to prevent pregnancy after unprotected sex. It is also used to treat symptomatic uterine fibroids, which can cause heavy bleeding and pain.
Ulipristal acetate works by blocking progesterone receptors in the body. This prevents ovulation, helping to prevent pregnancy. For fibroids, it alters hormonal levels that cause fibroids to grow, reducing their size.
For emergency contraception, the usual dose is one 30 mg tablet taken as soon as possible within 120 hours (5 days) after unprotected sex. For uterine fibroids, the dose is typically 5 mg once daily for up to 3 months, depending on doctor's recommendations.
Common side effects of Ulipristal acetate can include headaches, nausea, abdominal pain, and irregular bleeding. Rarely, it can cause liver problems, allergic reactions, or severe menstrual irregularities.
Ulipristal acetate should be avoided by women who are pregnant, have severe liver issues, or have unexplained vaginal bleeding. It's not recommended for regular contraception use.
Indications and Purpose
How does Ulipristal acetate work?
Ulipristal acetate works by blocking progesterone receptors in the body, which prevents ovulation (in emergency contraception) and reduces fibroid size by altering hormonal levels that cause fibroids to grow.
Is Ulipristal acetate effective?
Ulipristal acetate is highly effective for emergency contraception, preventing about 85% of pregnancies if taken within 5 days of unprotected sex. It is also effective in treating uterine fibroids, with significant symptom relief and fibroid shrinkage reported in many women.
What is Ulipristal acetate?
Ulipristal acetate is an emergency contraceptive pill that helps prevent pregnancy after unprotected sex or birth control failure. It works by delaying or preventing the release of an egg from the ovary and altering the lining of the uterus. It's not intended for regular use and doesn't protect against sexually transmitted infections (STIs). For best results, take it within 120 hours (5 days) of unprotected sex.
Directions for Use
For how long do I take Ulipristal acetate?
For emergency contraception, it is a single dose. For fibroids, ulipristal is taken for up to 3 months, and your doctor may recommend additional treatment cycles if necessary.
How do I take Ulipristal acetate?
For emergency contraception, ulipristal acetate should be taken as soon as possible after unprotected sex, either with or without food. If vomiting occurs within 3 hours, another dose may be needed. For fibroids, the daily dose should be taken consistently at the same time each day, as prescribed by your doctor.
How long does it take for Ulipristal acetate to start working?
For emergency contraception, ulipristal acetate works immediately after taking it by preventing ovulation. For fibroids, it may take several weeks to notice a reduction in symptoms like heavy bleeding and pelvic pain.
How should I store Ulipristal acetate?
Store ulipristal acetate at room temperature (below 30°C), away from moisture and heat. Keep the medication out of reach of children.
What is the usual dose of Ulipristal acetate?
For emergency contraception, the usual dose is one 30 mg tablet taken as soon as possible within 120 hours (5 days) after unprotected sex. For uterine fibroids, the dose is typically 5 mg once daily for up to 3 months, depending on the doctor’s recommendations.
Warnings and Precautions
Can I take Ulipristal acetate with other prescription drugs?
Ulipristal may interact with drugs such as epilepsy medications, antibiotics, and hormonal contraceptives, potentially reducing its effectiveness. Always check with your doctor if you're on other medications.
Can Ulipristal acetate be taken safely while breastfeeding?
It is advised to avoid breastfeeding for one week after taking ulipristal acetate, as it can pass into breast milk. Consult your doctor if you are breastfeeding.
Can Ulipristal acetate be taken safely while pregnant?
Ulipristal acetate is not recommended during pregnancy. It is used to prevent pregnancy and may harm the fetus if taken while pregnant.
Is it safe to drink alcohol while taking Ulipristal acetate?
While moderate alcohol consumption is generally considered safe with ulipristal acetate, drinking excessive alcohol may increase side effects such as dizziness or nausea. It's best to drink alcohol in moderation and be aware of how your body reacts.
Is it safe to exercise while taking Ulipristal acetate?
There are no known restrictions on exercise while taking ulipristal acetate. However, if you experience stomach pain, dizziness, or fatigue, it may be best to avoid strenuous activity until the side effects subside. Always listen to your body and consult your doctor if in doubt.
Is Ulipristal acetate safe for the elderly?
Ulipristal is typically not prescribed to the elderly, as it is mainly intended for women of reproductive age. Always consult with a doctor if the patient is older.
Who should avoid taking Ulipristal acetate?
Ulipristal acetate should be avoided by women who are pregnant, have severe liver issues, or have unexplained vaginal bleeding. It is also not recommended for use as a regular form of contraception.
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