Tipranavir
Acquired Immunodeficiency Syndrome
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Protease Inhibitor
Controlled Drug Substance
No
Tipranavir
Summary
Tipranavir is used to treat HIV-1 infection in adults and children who weigh at least 36 kg. It's specifically used for those who have previously taken HIV medications and have resistant strains of the virus.
Tipranavir works by blocking the HIV protease enzyme. This prevents the virus from maturing and multiplying, which reduces the amount of HIV in the blood and slows down the progression of the disease.
The usual dose for Tipranavir is 500 mg taken with 200 mg of ritonavir twice daily. It's taken orally and should be swallowed whole without chewing or crushing. Always follow your doctor's instructions.
Common side effects of Tipranavir include diarrhea, nausea, vomiting, headache, tiredness, and fatigue. Serious adverse effects include liver damage and bleeding in the brain. If you experience severe symptoms, contact your doctor immediately.
Tipranavir can cause severe liver damage and bleeding in the brain, which can be life-threatening. It's contraindicated in patients with moderate to severe liver impairment and those taking certain medications. It should not be taken with certain drugs like alfuzosin, amiodarone, and St. John's wort. High doses of vitamin E can increase bleeding risk. Always consult your doctor before taking any supplements.
Indications and Purpose
How does Tipranavir work?
Tipranavir is a protease inhibitor that blocks the HIV protease enzyme, preventing the virus from maturing and multiplying. This helps reduce the viral load in the body.
Is Tipranavir effective?
Tipranavir is proven effective in reducing HIV-1 RNA levels in treatment-experienced patients with resistant HIV strains. Clinical trials have shown its efficacy when used with ritonavir and other antiretrovirals.
What is Tipranavir?
Tipranavir is used with ritonavir and other medications to treat HIV-1 in treatment-experienced patients. It works by inhibiting the protease enzyme, reducing the amount of HIV in the blood and slowing disease progression.
Directions for Use
For how long do I take Tipranavir?
Tipranavir is used as part of a long-term treatment plan for HIV. The duration depends on individual response and medical advice. Do not stop taking it without consulting your doctor.
How do I take Tipranavir?
Take Tipranavir with ritonavir twice daily with meals. Swallow the capsules whole without chewing or crushing. Follow your doctor's instructions and avoid alcohol to reduce liver damage risk.
How long does it take for Tipranavir to start working?
Tipranavir begins to reduce HIV levels soon after starting treatment, but it may take several weeks to see significant changes. Regular monitoring by your doctor will help assess its effectiveness.
How should I store Tipranavir?
Store unopened bottles in the refrigerator. Once opened, keep them at room temperature and use within 60 days. Keep out of reach of children and away from excess heat and moisture.
What is the usual dose of Tipranavir?
The usual dose for adults and children weighing at least 36 kg is 500 mg of Tipranavir taken with 200 mg of ritonavir, twice daily. Always follow your doctor's specific instructions.
Warnings and Precautions
Can I take Tipranavir with other prescription drugs?
Tipranavir interacts with many drugs, including those metabolized by CYP3A. It should not be taken with certain medications like alfuzosin, amiodarone, and St. John's wort, as these can cause serious reactions.
Can Tipranavir be taken safely while breastfeeding?
Breastfeeding is not recommended for HIV-positive mothers due to the risk of HIV transmission and potential adverse effects on the infant from Tipranavir.
Can Tipranavir be taken safely while pregnant?
There is limited data on Tipranavir use during pregnancy. It should be used only if the potential benefit justifies the risk to the fetus. Pregnant women should register with the Antiretroviral Pregnancy Registry.
Is it safe to drink alcohol while taking Tipranavir?
Drinking alcohol can increase the risk of liver damage when taking Tipranavir, especially if you have liver problems or consume large amounts of alcohol. It's best to avoid alcohol or discuss with your doctor.
Is Tipranavir safe for the elderly?
Caution is advised for elderly patients due to the greater likelihood of decreased liver, kidney, or heart function, and the presence of other diseases or medications. Regular monitoring is recommended.
Who should avoid taking Tipranavir?
Tipranavir can cause severe liver damage and bleeding in the brain, which can be life-threatening. It is contraindicated in patients with moderate to severe liver impairment and those taking certain medications.
