Tafenoquine
Malaria
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
No
Tafenoquine
Summary
Tafenoquine is used to prevent the relapse of malaria in patients receiving chloroquine and to prevent malaria in travelers visiting areas where malaria is common.
Tafenoquine is an antimalarial medication that targets the liver stages of the malaria parasite, including the dormant forms. This stops the recurrence of malaria and prevents the development of the parasites erythrocytic forms.
Tafenoquine is typically taken as a single dose of 300 mg, which is administered as two 150 mg tablets taken together. It should be taken with food to increase absorption.
Common side effects of Tafenoquine include dizziness, nausea, vomiting, and headache. Serious adverse effects can include hemolytic anemia, methemoglobinemia and psychiatric symptoms such as anxiety and abnormal dreams.
Tafenoquine should not be used by individuals with G6PD deficiency, during pregnancy, or breastfeeding if the infant's G6PD status is unknown due to the risk of hemolytic anemia. It should be used cautiously in patients with a history of psychiatric disorders.
Indications and Purpose
How does Tafenoquine work?
Tafenoquine works by killing the malaria parasites in the blood and liver. It disrupts the parasites' life cycle, preventing them from multiplying. Think of it like cutting off the power supply to a machine, stopping it from working. This helps prevent and treat malaria effectively.
Is Tafenoquine effective?
Yes, Tafenoquine is effective for preventing and treating malaria, which is an infection caused by parasites transmitted through mosquito bites. Clinical studies show that Tafenoquine is effective in preventing malaria and treating the liver stage of the parasite. It is important to follow your doctor's instructions to ensure the best outcomes.
What is Tafenoquine?
Tafenoquine is a medication used to prevent and treat malaria, which is an infection caused by parasites transmitted through mosquito bites. It belongs to the antimalarial class of drugs. Tafenoquine works by killing the parasites in the blood and liver, helping to prevent and treat malaria effectively.
Directions for Use
For how long do I take Tafenoquine?
Tafenoquine is usually taken as a single dose for malaria prevention or treatment. The duration of use depends on your specific treatment plan. Always follow your doctor's instructions on how long to take Tafenoquine. If you have questions about your treatment duration, consult your healthcare provider.
How do I dispose of Tafenoquine?
To dispose of Tafenoquine, bring unused medicine to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Tafenoquine?
Tafenoquine is usually taken as a single dose. It's important to follow your doctor's instructions on how to take it. You can take it with or without food. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about taking this medication.
How long does it take for Tafenoquine to start working?
Tafenoquine starts working soon after you take it, but the time to see full effects can vary. For malaria prevention, it works quickly to protect against infection. For treatment, symptoms should improve within a few days. Individual factors like overall health can affect how quickly you notice benefits.
How should I store Tafenoquine?
Store Tafenoquine at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep it out of children's reach to prevent accidental swallowing.
What is the usual dose of Tafenoquine?
The usual dose of Tafenoquine for adults is a single 300 mg tablet taken once. It's important to follow your doctor's specific dosing instructions. There may be different dosing recommendations for special populations, such as children or the elderly. Always consult your healthcare provider for personalized dosing advice.
Warnings and Precautions
Can I take Tafenoquine with other prescription drugs?
Tafenoquine can interact with other medications, increasing the risk of side effects. It's important to inform your doctor about all the medicines you take, including over-the-counter drugs and supplements. Your doctor can help identify potential interactions and adjust your treatment plan to ensure safety.
Can Tafenoquine be taken safely while breastfeeding?
Tafenoquine is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to the nursing infant. If you're breastfeeding and need malaria prevention or treatment, talk with your doctor about safer medication options.
Can Tafenoquine be taken safely while pregnant?
Tafenoquine is not recommended during pregnancy. There is limited evidence on its safety for pregnant women, and it may pose risks to the developing baby. If you're pregnant or planning to become pregnant, talk with your doctor about safer alternatives for malaria prevention or treatment.
Does Tafenoquine have adverse effects?
Adverse effects are unwanted reactions to a medication. Tafenoquine can cause side effects like nausea, vomiting, and dizziness. These are generally mild and temporary. A serious adverse effect is hemolytic anemia in people with G6PD deficiency, which requires immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Tafenoquine.
Does Tafenoquine have any safety warnings?
Yes, Tafenoquine has important safety warnings. It can cause hemolytic anemia, which is the destruction of red blood cells, in people with G6PD deficiency, a genetic condition. Before taking Tafenoquine, you should be tested for G6PD deficiency. Not adhering to this warning can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Tafenoquine?
It's best to avoid alcohol while taking Tafenoquine. Alcohol can increase the risk of side effects like dizziness and nausea. If you choose to drink, limit your intake and watch for warning signs like dizziness or stomach upset. Talk with your doctor about alcohol use while taking Tafenoquine for personalized advice.
Is it safe to exercise while taking Tafenoquine?
You can exercise while taking Tafenoquine, but be cautious. This medication can cause dizziness, which might affect your balance during physical activity. To exercise safely, stay hydrated and avoid strenuous activities if you feel dizzy. If you notice any unusual symptoms, slow down or stop exercising and rest.
Is it safe to stop Tafenoquine?
Tafenoquine is usually taken as a single dose for malaria prevention or treatment, so stopping it isn't typically an issue. However, if you're on a specific treatment plan, follow your doctor's instructions. Stopping early might not fully treat the infection. Always consult your doctor before making changes to your medication regimen.
Is Tafenoquine addictive?
Tafenoquine is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Tafenoquine works by affecting the parasites in your body, not your brain chemistry, so it doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Tafenoquine safe for the elderly?
The elderly may be more vulnerable to side effects from Tafenoquine, such as dizziness and nausea. It's important for older adults to be monitored closely by their healthcare provider while taking this medication. Always consult your doctor about the risks and benefits of Tafenoquine for elderly patients.
What are the most common side effects of Tafenoquine?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Tafenoquine include nausea, vomiting, and dizziness. These effects vary from person to person and are usually mild. If you notice new symptoms after starting Tafenoquine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Tafenoquine?
Tafenoquine should not be used in people with G6PD deficiency, which is a genetic condition that affects red blood cells. This is an absolute contraindication due to the risk of hemolytic anemia, which is the destruction of red blood cells. Pregnant women and breastfeeding mothers should also avoid Tafenoquine. Always consult your doctor about these concerns.
