Tacrolimus

Atopic Dermatitis, Graft vs Host Disease

Drug Status

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Government Approvals

UK(BNF)

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WHO Essential Medicine

YES

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Known Teratogen

NO

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Pharmaceutical Class

Calcineurin Inhibitor Immunosuppressant

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Controlled Drug Substance

NO

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Drug Ingredient

Tacrolimus

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Summary

  • Tacrolimus is primarily used to prevent organ rejection after a transplant, such as a kidney transplant. It works by suppressing the immune system to prevent it from attacking the transplanted organ.

  • Tacrolimus binds to a protein called FKBP12 in your body. This forms a complex that inhibits an enzyme known as calcineurin, which is crucial for activating T-cells. By doing this, it reduces the production of inflammatory cytokines, preventing immune system attacks on transplanted organs.

  • Tacrolimus is typically taken as an extended-release capsule every morning at the same time, ideally on an empty stomach. The exact dosage depends on your weight and medical condition, and is determined by your doctor.

  • Common side effects of Tacrolimus include diarrhea, nausea, and tremors. It may also cause headaches, dizziness, and changes in appetite or mood. Less commonly, it can cause neurological effects like confusion or tremors.

  • Tacrolimus should not be taken if you're allergic or have had a liver transplant without consulting your doctor. It can cause serious side effects like high blood pressure, high blood sugar, kidney issues, and blood clots. It may also increase your risk of getting cancer and infections. It's crucial to avoid grapefruit and alcohol while taking this medication.

Indications and Purpose

Directions for Use

Warnings and Precautions