Suvorexant
Sleep Initiation and Maintenance Disorders
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Orexin Receptor Antagonist
Controlled Drug Substance
No
Suvorexant
Summary
Suvorexant is used to treat insomnia, specifically for people who have trouble falling asleep or staying asleep.
Suvorexant works by blocking orexin receptors in the brain. Orexin is a substance that promotes wakefulness, so by blocking it, Suvorexant helps you fall asleep and stay asleep.
The usual dose for adults is 10 mg, taken once per night within 30 minutes of going to bed. If needed, the dose can be increased to a maximum of 20 mg.
Common side effects of Suvorexant include drowsiness, headaches, and unusual dreams. More serious side effects can include complex sleep behaviors like sleep-driving, and worsening of depression or suicidal thoughts.
Suvorexant may cause next-day drowsiness and complex sleep behaviors. It can also potentially worsen depression or suicidal thoughts. It's not recommended for patients with narcolepsy. You should avoid alcohol and other CNS depressants while taking this medication, and be cautious when driving or operating machinery.
Indications and Purpose
How does Suvorexant work?
Suvorexant works by blocking the action of orexin, a natural substance in the brain that promotes wakefulness, thereby helping you fall asleep and stay asleep.
Is Suvorexant effective?
Clinical studies have shown that Suvorexant is effective in improving sleep onset and maintenance in patients with insomnia. It has been found to reduce the time it takes to fall asleep and increase total sleep time compared to placebo.
What is Suvorexant?
Suvorexant is used to treat insomnia, helping people fall asleep and stay asleep. It works by blocking orexin receptors in the brain, which are involved in wakefulness, thereby promoting sleep.
Directions for Use
For how long do I take Suvorexant?
Suvorexant is typically used for short-term treatment of insomnia. If sleep problems do not improve within 7 to 10 days, it is important to consult a doctor as this may indicate an underlying condition.
How do I take Suvorexant?
Take Suvorexant once per night, within 30 minutes of going to bed, ensuring you have at least 7 hours to sleep. It can be taken with or without food, but it may work faster on an empty stomach. Avoid alcohol while taking this medication.
How long does it take for Suvorexant to start working?
Suvorexant typically starts working within 30 minutes of taking it, helping you fall asleep faster.
How should I store Suvorexant?
Store Suvorexant at room temperature, between 20°C to 25°C (68°F to 77°F), in its original package to protect from light and moisture. Keep it out of reach of children and in a safe place to prevent misuse.
What is the usual dose of Suvorexant?
The usual dose for adults is 10 mg taken once per night, within 30 minutes of going to bed. The maximum dose is 20 mg per night. Suvorexant is not recommended for children as its safety and effectiveness have not been established in this age group.
Warnings and Precautions
Can I take Suvorexant with other prescription drugs?
Suvorexant can interact with CNS depressants, increasing the risk of drowsiness and impaired alertness. It should not be used with strong CYP3A inhibitors, as they can increase Suvorexant levels in the body.
Can Suvorexant be taken safely while breastfeeding?
There is no data on the presence of Suvorexant in human milk. It is important to weigh the benefits of breastfeeding against the mother's need for Suvorexant and any potential effects on the breastfed infant. Consult a doctor for personalized advice.
Can Suvorexant be taken safely while pregnant?
There is insufficient data on the use of Suvorexant during pregnancy to determine its safety. It should only be used if the potential benefit justifies the potential risk to the fetus. Consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Suvorexant?
Drinking alcohol while taking Suvorexant can increase the risk of side effects such as drowsiness and impaired alertness. It is advised not to consume alcohol in combination with Suvorexant to avoid additive effects that can impair your ability to perform tasks that require full mental alertness.
Is it safe to exercise while taking Suvorexant?
Suvorexant may cause drowsiness and decreased mental alertness, which could affect your ability to exercise safely. It is important to ensure you are fully awake and alert before engaging in physical activities.
Is Suvorexant safe for the elderly?
Elderly patients using Suvorexant should be cautious due to an increased risk of falls and next-day drowsiness. They should avoid activities requiring full alertness, such as driving, until they know how the medication affects them. Consult a doctor for personalized advice.
Who should avoid taking Suvorexant?
Suvorexant is contraindicated in patients with narcolepsy. It can cause next-day drowsiness, complex sleep behaviors, and may worsen depression or suicidal thoughts. Avoid alcohol and other CNS depressants while taking this medication.
