Sunitinib
Renal Cell Carcinoma, Gastrointestinal Stromal Tumors ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Sunitinib
Summary
Sunitinib is used to treat certain types of cancer such as gastrointestinal stromal tumors (GIST), advanced renal cell carcinoma (RCC), and pancreatic neuroendocrine tumors (pNET). These are types of tumors that occur in the stomach, kidneys, and pancreas respectively.
Sunitinib works by targeting and inhibiting certain proteins that promote cancer cell growth and spread. This helps to slow or stop the growth of tumors and control the progression of the cancer.
Sunitinib is taken orally. For GIST and RCC, the recommended dose is 50 mg once daily for 4 weeks, followed by a 2-week break. For pNET, the usual dose is 37.5 mg taken once daily.
Common side effects include fatigue, diarrhea, nausea, and decreased appetite. Serious side effects can include liver damage, heart problems, and high blood pressure.
Sunitinib can cause serious side effects including liver damage and heart problems. It's not recommended for use during pregnancy and breastfeeding. Patients with a history of liver disease, heart conditions, or bleeding disorders should use it with caution. Always inform your healthcare provider of all medical conditions and medications before starting Sunitinib.
Indications and Purpose
How does Sunitinib work?
Sunitinib is a kinase inhibitor that targets multiple receptor tyrosine kinases (RTKs) involved in tumor growth and angiogenesis. By blocking these RTKs, Sunitinib disrupts the signaling pathways that promote cancer cell proliferation and blood vessel formation, thereby slowing or stopping the growth and spread of tumors. This action helps to control the progression of certain cancers.
Is Sunitinib effective?
Sunitinib has been shown to be effective in treating certain types of cancer, including gastrointestinal stromal tumors (GIST), advanced renal cell carcinoma (RCC), and pancreatic neuroendocrine tumors (pNET). Clinical trials have demonstrated its ability to improve progression-free survival and, in some cases, overall survival in these conditions. Sunitinib works by inhibiting specific proteins that promote cancer cell growth and spread.
What is Sunitinib?
Sunitinib is used to treat certain types of cancer, including gastrointestinal stromal tumors (GIST), advanced renal cell carcinoma (RCC), and pancreatic neuroendocrine tumors (pNET). It works by inhibiting specific proteins that promote cancer cell growth and spread, helping to slow or stop tumor progression. Sunitinib is taken orally and requires regular monitoring to manage side effects and ensure effectiveness.
Directions for Use
For how long do I take Sunitinib?
The duration of Sunitinib treatment varies based on the condition being treated and the patient's response to the medication. For GIST and RCC, the treatment cycle is typically 4 weeks on followed by a 2-week break, repeated as long as the doctor recommends. For pNET, Sunitinib is usually taken continuously until disease progression or unacceptable toxicity occurs. Always follow your doctor's guidance on treatment duration.
How do I take Sunitinib?
Sunitinib can be taken with or without food. However, patients should avoid consuming grapefruit or grapefruit juice while taking this medication, as it can affect how the drug is metabolized in the body. Always follow your healthcare provider's instructions regarding dosage and administration, and consult them if you have any questions about dietary restrictions.
How long does it take for Sunitinib to start working?
The time it takes for Sunitinib to start working can vary depending on the individual and the condition being treated. Generally, it may take several weeks to observe a response to the medication. Regular monitoring and follow-up appointments with your healthcare provider are important to assess the effectiveness of the treatment and make any necessary adjustments.
How should I store Sunitinib?
Sunitinib should be stored in its original container, tightly closed, and kept out of reach of children. It should be stored at room temperature, away from excess heat and moisture, and not in the bathroom. Proper storage helps maintain the medication's effectiveness and safety. If you have any questions about storage, consult your pharmacist or healthcare provider.
What is the usual dose of Sunitinib?
For adults, the usual daily dose of Sunitinib varies depending on the condition being treated. For gastrointestinal stromal tumors (GIST) and advanced renal cell carcinoma (RCC), the recommended dose is 50 mg taken orally once daily for 4 weeks, followed by a 2-week break. For pancreatic neuroendocrine tumors (pNET), the dose is typically 37.5 mg taken once daily. For children, the safety and efficacy of Sunitinib have not been established, and dosing should be determined by a healthcare provider.
Warnings and Precautions
Can I take Sunitinib with other prescription drugs?
Sunitinib can interact with certain medications, including strong CYP3A4 inhibitors like ketoconazole, which may increase Sunitinib levels in the blood, and CYP3A4 inducers like rifampin, which may decrease its effectiveness. It's important to inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. Your doctor may adjust your dose or suggest alternative medications.
Can Sunitinib be taken safely while breastfeeding?
Women are advised not to breastfeed during treatment with Sunitinib and for at least 4 weeks after the last dose. This is due to the potential for serious adverse reactions in breastfed infants. If you are breastfeeding or plan to breastfeed, discuss this with your healthcare provider to determine the best course of action.
Can Sunitinib be taken safely while pregnant?
Sunitinib can cause fetal harm and is not recommended for use during pregnancy. Women of reproductive potential should use effective contraception during treatment and for at least 4 weeks after the last dose. Men with female partners of reproductive potential should also use contraception during treatment and for 7 weeks after the last dose. If pregnancy occurs while taking Sunitinib, contact your healthcare provider immediately. There is strong evidence from animal studies indicating potential harm to the fetus.
Is it safe to exercise while taking Sunitinib?
Sunitinib may cause fatigue, which could limit your ability to exercise. If you experience fatigue or any other symptoms that affect your ability to exercise, it's important to discuss this with your healthcare provider. They can provide guidance on managing these side effects and advise on safe levels of physical activity during treatment.
Is Sunitinib safe for the elderly?
Elderly patients (65 years and older) may experience a higher incidence of severe side effects when taking Sunitinib. It's important for elderly patients to be closely monitored by their healthcare provider for any adverse reactions. Dose adjustments may be necessary based on individual tolerance and response to the medication. Always follow your doctor's guidance when using Sunitinib.
Who should avoid taking Sunitinib?
Sunitinib can cause serious side effects, including liver damage, heart problems, and high blood pressure. It may also lead to bleeding, gastrointestinal issues, and skin reactions. Patients with a history of liver disease, heart conditions, or bleeding disorders should use Sunitinib with caution. It's important to inform your healthcare provider of all medical conditions and medications before starting Sunitinib. Regular monitoring and blood tests are recommended to ensure safe use.
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