Sulfasalazine

Juvenile Arthritis, Ulcerative Colitis ... show more

Drug Status

approvals.svg

Government Approvals

US(FDA), UK(BNF)

approvals.svg

WHO Essential Medicine

YES

approvals.svg

Known Teratogen

NO

approvals.svg

Pharmaceutical Class

Aminosalicylate

approvals.svg

Controlled Drug Substance

NO

Video Thumbnail
Drug Ingredient

Sulfasalazine

Learn more about this brand -

Click Here

Summary

  • Sulfasalazine is primarily used to treat inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease, including ulcerative colitis. It may also be used for Crohn's disease and ankylosing spondylitis.

  • Sulfasalazine works by reducing inflammation in the body. It is broken down in the colon, releasing its active ingredients which control inflammation in the intestines and joints.

  • Sulfasalazine is usually taken orally in tablet form with food to reduce stomach irritation. Adults typically start with a high dose of 3-4 grams per day, which can be reduced to a maintenance dose of 2 grams per day once symptoms improve.

  • Common side effects of Sulfasalazine include stomach upset, nausea, diarrhea, rash, headache, or dizziness. In rare cases, it can lead to blood disorders or liver and kidney issues.

  • People with a history of severe allergic reactions to sulfa drugs or salicylates, certain blood disorders, or liver or kidney issues should avoid or use Sulfasalazine cautiously. It's important to inform your doctor about all the medications you're taking as Sulfasalazine can interact with certain antibiotics, blood thinners, and other immunesuppressing drugs.

Indications and Purpose

How does one know if Sulfasalazine is working?

You should notice a reduction in symptoms like joint pain, swelling, and digestive issues. Your doctor will also monitor blood tests to assess its effectiveness.

How does Sulfasalazine work?

Sulfasalazine works by reducing inflammation in the body. It is broken down in the colon to release its active ingredients, which help to control inflammation in the intestines and joints.

Is Sulfasalazine effective?

Yes, Sulfasalazine is effective for many people in reducing inflammation and managing symptoms of rheumatoid arthritis and IBD.

What is Sulfasalazine?

Sulfasalazine is a medication used primarily to treat inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease (IBD), including ulcerative colitis.

What is Sulfasalazine used for?

  • Rheumatoid arthritis
  • Ulcerative colitis and other forms of IBD
  • It may also be used for Crohn’s disease and ankylosing spondylitis.

Directions for Use

For how long do I take Sulfasalazine?

The length of treatment depends on the condition. For chronic conditions like rheumatoid arthritis or ulcerative colitis, Sulfasalazine may be taken long-term.

How do I take Sulfasalazine?

it is usually taken by mouth in the form of tablets, with food to reduce stomach irritation.

How long does it take for Sulfasalazine to start working?

It may take 2 to 3 weeks for initial improvement in symptoms, but full effects can take up to 6 weeks or longer.

How should I store Sulfasalazine?

Store at room temperature, away from moisture and heat, and keep it tightly closed in its original container.

What is the usual dose of Sulfasalazine?

Sulfasalazine's dose depends on the person's age and whether they're starting treatment or continuing it.  Adults usually start with a high dose (3-4 grams a day, split up) but can start lower (1-2 grams) if they have stomach problems.  The highest safe dose is 4 grams a day. Once better, adults usually take a lower maintenance dose (2 grams a day).  Children (6 and older) have their doses calculated based on their weight, with higher doses at the start and lower ones later.  

Warnings and Precautions

Can I take Sulfasalazine with other prescription drugs?

It may interact with other medications, such as certain antibiotics, blood thinners, or other immune-suppressing drugs. Always inform your doctor about all the medications you're taking.

Can I take Sulfasalazine with vitamins or supplements?

Yes, but talk to your doctor if you're taking high doses of folic acid or other supplements, as they can interact with Sulfasalazine.

Can Sulfasalazine be taken safely while breastfeeding?

Sulfasalazine passes into breast milk, so it should be used cautiously during breastfeeding. Consult your doctor for advice.

Can Sulfasalazine be taken safely while pregnant?

Sulfasalazine is generally considered safe during pregnancy, but it should be used only when necessary and under a doctor’s supervision.

Is it safe to drink alcohol while taking Sulfasalazine?

It’s best to limit alcohol, as it can irritate your stomach and increase side effects like liver issues.

Is it safe to exercise while taking Sulfasalazine?

Yes, exercise is generally safe, but avoid strenuous activity if you're feeling unwell or have joint pain.

Is Sulfasalazine safe for the elderly?

Yes, but elderly people may be more sensitive to side effects, particularly related to blood counts or liver function, so regular monitoring is recommended.

Who should avoid taking Sulfasalazine?

People with:

  • A history of severe allergic reactions to sulfa drugs or salicylates
  • Certain blood disorders (e.g., low white blood cell count)
  • Liver or kidney issues should avoid or use it cautiously.