Sotorasib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
No
Sotorasib
Summary
Sotorasib is used to treat certain types of non-small cell lung cancer and metastatic colorectal cancer that have a specific KRAS G12C mutation.
Sotorasib works by inhibiting a mutant protein called KRAS G12C. This protein signals cancer cells to multiply. By inhibiting it, Sotorasib helps to stop or slow the spread of cancer.
The usual daily dose of Sotorasib for adults is 960 mg taken orally once a day. It is not recommended for children as its safety and effectiveness have not been established in pediatric patients.
Common side effects of Sotorasib include diarrhea, nausea, fatigue, and hepatotoxicity, which is a condition that can damage your liver. Serious adverse effects can include liver problems and interstitial lung disease.
Important warnings for Sotorasib include the risk of hepatotoxicity and interstitial lung disease. Patients should be monitored for liver function and respiratory symptoms. There are no known contraindications, but you should always inform your doctor of any medical conditions or medications you are taking.
Indications and Purpose
How does Sotorasib work?
Sotorasib works by inhibiting the KRAS G12C protein, a mutant form of the RAS GTPase. It forms an irreversible bond with the protein, locking it in an inactive state, which prevents cancer cells from multiplying and spreading. This helps to slow or stop the progression of cancer.
Is Sotorasib effective?
Sotorasib has been shown to be effective in treating KRAS G12C-mutated non-small cell lung cancer (NSCLC) and metastatic colorectal cancer (mCRC). Clinical trials demonstrated significant improvements in progression-free survival and overall response rates in patients with these mutations. Always consult your doctor for personalized advice.
What is Sotorasib?
Sotorasib is used to treat certain types of non-small cell lung cancer and metastatic colorectal cancer with a specific KRAS G12C mutation. It works by inhibiting the abnormal protein that signals cancer cells to multiply, helping to stop or slow the spread of cancer. Always consult your doctor for personalized advice.
Directions for Use
For how long do I take Sotorasib?
Sotorasib is typically used until disease progression or unacceptable toxicity occurs. The duration of use can vary based on individual response and tolerance to the medication. Always follow your doctor's guidance regarding the length of treatment.
How do I take Sotorasib?
Take Sotorasib once daily, with or without food, at the same time each day. Swallow the tablets whole without chewing, crushing, or splitting. If you cannot swallow the tablets, disperse them in water as instructed. Avoid using other liquids. Follow your doctor's instructions for any specific dietary restrictions.
How should I store Sotorasib?
Store Sotorasib at room temperature between 68°F to 77°F (20°C to 25°C). Keep it in its original container, tightly closed, and out of reach of children. Protect it from light, excess heat, and moisture. Do not store it in the bathroom.
What is the usual dose of Sotorasib?
The usual daily dose of Sotorasib for adults is 960 mg, taken orally once daily. The safety and effectiveness of Sotorasib have not been established in pediatric patients, so there is no recommended dose for children. Always follow your doctor's advice for the correct dosage.
Warnings and Precautions
Can I take Sotorasib with other prescription drugs?
Sotorasib can interact with acid-reducing agents like proton pump inhibitors and H2 receptor antagonists, which may decrease its effectiveness. It also interacts with CYP3A4 substrates and inducers, potentially affecting drug levels. Always inform your doctor of all medications you are taking.
Can Sotorasib be taken safely while breastfeeding?
There is no data on the presence of Sotorasib in human milk or its effects on the breastfed child. Due to potential serious adverse reactions, women are advised not to breastfeed during treatment and for 1 week after the last dose. Consult your doctor for personalized advice.
Can Sotorasib be taken safely while pregnant?
There are no available data on Sotorasib use in pregnant women. Animal studies did not show adverse developmental effects. However, due to the potential for harm, it is advised to avoid using Sotorasib during pregnancy. Always consult your doctor for personalized advice.
Is Sotorasib safe for the elderly?
No overall differences in safety or effectiveness were observed between older patients and younger patients treated with Sotorasib. However, elderly patients should be monitored closely for side effects, as they may be more susceptible to adverse reactions. Always follow your doctor's guidance.
Who should avoid taking Sotorasib?
Important warnings for Sotorasib include the risk of hepatotoxicity and interstitial lung disease (ILD)/pneumonitis. Patients should be monitored for liver function and respiratory symptoms. There are no known contraindications, but always inform your doctor of any medical conditions or medications you are taking.
