Sildenafil
Pulmonary Hypertension, Vasculogenic Impotence
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Phosphodiesterase 5 Inhibitor
Controlled Drug Substance
No
Sildenafil
Summary
Sildenafil is used to treat erectile dysfunction, which is the inability to achieve or maintain an erection, and pulmonary arterial hypertension, which is high blood pressure in the lungs.
Sildenafil works by inhibiting an enzyme called phosphodiesterase type 5, which regulates blood flow in the penis. This increases blood flow during sexual stimulation, helping to achieve and maintain an erection.
The usual starting dose of Sildenafil for adults is 50 mg taken as needed, about 1 hour before sexual activity. It can be adjusted to 25 mg or 100 mg based on effectiveness and tolerance.
Common side effects of Sildenafil include headaches, flushing, and indigestion, which are usually mild and temporary.
Sildenafil should not be used with nitrates, which are medications for chest pain, as this can cause a dangerous drop in blood pressure. It is also contraindicated in people with severe heart or liver problems.
Indications and Purpose
How does Sildenafil work?
Sildenafil works by inhibiting an enzyme called phosphodiesterase type 5, which regulates blood flow in the penis. By blocking this enzyme, Sildenafil increases blood flow to the penis during sexual stimulation, helping to achieve and maintain an erection. This process is similar to opening a valve to allow more water to flow through a pipe.
Is Sildenafil effective?
Sildenafil is effective for treating erectile dysfunction, which is the inability to achieve or maintain an erection. It works by increasing blood flow to the penis during sexual stimulation. Clinical studies show that Sildenafil significantly improves erectile function in most men. If you have concerns about its effectiveness, discuss them with your doctor.
What is Sildenafil?
Sildenafil is a medication used to treat erectile dysfunction, which is the inability to achieve or maintain an erection. It belongs to a class of drugs called phosphodiesterase type 5 inhibitors, which work by increasing blood flow to the penis during sexual stimulation. Sildenafil is also used to treat pulmonary arterial hypertension, which is high blood pressure in the lungs.
Directions for Use
For how long do I take Sildenafil?
Sildenafil is taken as needed for erectile dysfunction, usually about 30 minutes to 1 hour before sexual activity. It is not intended for daily use unless prescribed by your doctor. The duration of use depends on your individual needs and response to the medication. Always follow your doctor's instructions.
How do I dispose of Sildenafil?
Dispose of unused Sildenafil by taking it to a drug take-back program or collection site at a pharmacy. If unavailable, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Sildenafil?
Take Sildenafil as prescribed by your doctor, usually about 30 minutes to 1 hour before sexual activity. It can be taken with or without food, but a high-fat meal may delay its effect. Do not crush or chew the tablet. If you miss a dose, take it when you remember, but do not take more than one dose per day. Avoid alcohol, as it can reduce the effectiveness of the medication.
How long does it take for Sildenafil to start working?
Sildenafil usually starts working within 30 minutes to 1 hour after taking it. The full effect can be achieved within this time frame. Factors like a high-fat meal can delay its onset. For best results, take it on an empty stomach or after a light meal. Follow your doctor's instructions for optimal effectiveness.
How should I store Sildenafil?
Store Sildenafil at room temperature, away from moisture and light. Keep it in its original packaging and out of reach of children. Do not store it in the bathroom, where humidity can affect the medication. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Sildenafil?
The usual starting dose of Sildenafil for adults is 50 mg taken as needed, about 1 hour before sexual activity. Depending on effectiveness and tolerance, your doctor may adjust the dose to 25 mg or 100 mg. The maximum recommended dose is 100 mg per day. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can I take Sildenafil with other prescription drugs?
Sildenafil can interact with nitrates, which are medications for chest pain, causing a dangerous drop in blood pressure. It may also interact with certain blood pressure medications and alpha-blockers. Always inform your doctor about all medications you are taking to avoid interactions. They can help ensure safe and effective treatment.
Can Sildenafil be taken safely while breastfeeding?
Sildenafil is not intended for use while breastfeeding, as it is used to treat erectile dysfunction in men. There is limited information on its safety during breastfeeding. If you are breastfeeding and have concerns about medications, consult your doctor for advice on safe options.
Can Sildenafil be taken safely while pregnant?
Sildenafil is not intended for use during pregnancy, as it is used to treat erectile dysfunction in men. There is limited information on its safety during pregnancy. If you are pregnant or planning to become pregnant, consult your doctor for advice on safe medications for your condition.
Does Sildenafil have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Sildenafil include headaches, flushing, and indigestion. These occur in more than 10% of users. Serious side effects, like sudden vision loss or an erection lasting more than 4 hours, require immediate medical attention. Always report new or worsening symptoms to your doctor.
Does Sildenafil have any safety warnings?
Sildenafil has important safety warnings. It should not be used with nitrates, which are medications for chest pain, as this can cause a dangerous drop in blood pressure. If you experience chest pain, dizziness, or nausea during sex, seek immediate medical help. Always inform your doctor about all medications you are taking to avoid interactions.
Is it safe to drink alcohol while taking Sildenafil?
It's best to limit alcohol while taking Sildenafil. Alcohol can reduce the effectiveness of the medication and increase the risk of side effects like dizziness or low blood pressure. If you choose to drink, do so in moderation and be aware of any symptoms that may arise. Consult your doctor for personalized advice.
Is it safe to exercise while taking Sildenafil?
You can exercise while taking Sildenafil, but be cautious. Sildenafil can cause dizziness or lightheadedness, especially if you stand up quickly. Stay hydrated and avoid strenuous activities until you know how the medication affects you. If you experience unusual symptoms during exercise, stop and rest. Consult your doctor for personalized advice.
Is it safe to stop Sildenafil?
Sildenafil is used as needed for erectile dysfunction, so you can stop taking it without withdrawal symptoms. However, stopping may result in the return of erectile dysfunction symptoms. Always discuss with your doctor before making changes to your medication regimen to ensure it aligns with your health needs.
Is Sildenafil addictive?
Sildenafil is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms. Sildenafil works by increasing blood flow to the penis and does not affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Sildenafil safe for the elderly?
Sildenafil can be used by the elderly, but they may be more sensitive to its effects. Older adults are at higher risk for side effects like dizziness or low blood pressure. It's important to start with a lower dose and monitor for any adverse reactions. Consult your doctor for guidance tailored to your health needs.
What are the most common side effects of Sildenafil?
Side effects are unwanted reactions to a medication. Common side effects of Sildenafil include headaches, flushing, and indigestion, affecting more than 10% of users. These are usually mild and temporary. If you experience new symptoms after starting Sildenafil, they might be unrelated to the medication. Consult your doctor before stopping any medication.
Who should avoid taking Sildenafil?
Do not take Sildenafil if you are using nitrates for chest pain, as this can cause a dangerous drop in blood pressure. It is also contraindicated in people with severe heart or liver problems. Always inform your doctor about your medical history and current medications to ensure Sildenafil is safe for you.
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