Safinamide
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Monoamine Oxidase Type B Inhibitor
Controlled Drug Substance
No
Safinamide
Summary
Safinamide is primarily used to treat Parkinson's disease. It is often used in combination with other medications, such as levodopa, to help manage symptoms like tremors and rigidity.
Safinamide works by increasing dopamine levels in the brain and modulating the activity of glutamate. This helps improve motor function and reduce symptoms of Parkinson's disease.
The usual daily dosage of Safinamide for adults is 50 mg once daily, which may be increased to 100 mg once daily based on individual response and tolerance. It should be taken orally with or without food.
Common side effects of Safinamide include nausea, insomnia, dizziness, and headache. More severe side effects may include serotonin syndrome, hallucinations, confusion, mood changes, and worsening of movement-related symptoms.
Safinamide should not be combined with MAO inhibitors due to the risk of hypertensive crises or serotonin syndrome. It should be used with caution in patients with a history of mental health disorders or cardiovascular issues. It is also contraindicated in individuals with severe hepatic impairment.
Indications and Purpose
How does Safinamide work?
Safinamide works by inhibiting an enzyme called MAO-B, which breaks down certain chemicals in the brain. By blocking this enzyme, Safinamide increases the levels of these chemicals, improving motor function in people with Parkinson's disease. Think of it like a traffic controller, allowing more signals to pass through, which helps improve movement and reduce symptoms like tremors and stiffness.
Is Safinamide effective?
Safinamide is effective in treating Parkinson's disease, which is a condition that affects movement. It works by increasing levels of certain chemicals in the brain to improve motor function. Clinical studies show that Safinamide helps reduce symptoms like tremors and stiffness, improving overall quality of life for people with Parkinson's disease.
What is Safinamide?
Safinamide is a medication used to treat Parkinson's disease, which is a condition that affects movement. It belongs to a class of drugs called MAO-B inhibitors, which work by increasing levels of certain chemicals in the brain to improve motor function. Safinamide is used as an add-on treatment to other Parkinson's medications to help manage symptoms.
Directions for Use
For how long do I take Safinamide?
Safinamide is usually a long-term medication for managing Parkinson's disease, which is a chronic condition. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Safinamide?
To dispose of Safinamide, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Safinamide?
Take Safinamide as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Safinamide to start working?
Safinamide begins working in your body shortly after you take it, but you may not notice all the benefits right away. Some people may see improvements in symptoms within a few days, but more significant changes typically take several weeks. How quickly the medication works can depend on your overall health and how your body responds. Take it exactly as prescribed for the best results.
How should I store Safinamide?
Store Safinamide at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Safinamide out of children's reach to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Safinamide?
The usual starting dose of Safinamide for adults is 50 mg once daily. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 100 mg daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Safinamide with other prescription drugs?
Safinamide can interact with certain medications, increasing the risk of side effects. It should not be used with other MAO inhibitors, which are medications that affect brain chemicals, as this can lead to serious reactions. Inform your doctor about all the medicines you take to avoid potential interactions and ensure safe use.
Can Safinamide be taken safely while breastfeeding?
The safety of Safinamide while breastfeeding is not well-established. We don't have much information about whether it passes into human breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. Your doctor can help you make informed decisions about your treatment.
Can Safinamide be taken safely while pregnant?
The safety of Safinamide during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Does Safinamide have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Safinamide include nausea and insomnia, which is trouble sleeping. These effects are usually mild. Serious side effects like high blood pressure or hallucinations require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Safinamide.
Does Safinamide have any safety warnings?
Yes, Safinamide has important safety warnings. It may increase the risk of high blood pressure and hallucinations, which are seeing or hearing things that aren't there. If you experience these symptoms, contact your doctor immediately. Safinamide can also interact with certain medications, so inform your doctor about all the medicines you take. Not adhering to these warnings can lead to serious health issues.
Is it safe to drink alcohol while taking Safinamide?
It's best to avoid alcohol while taking Safinamide. Alcohol can increase the risk of side effects like dizziness or drowsiness. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or trouble concentrating. Talk with your doctor about alcohol use while taking Safinamide for personalized advice.
Is it safe to exercise while taking Safinamide?
You can exercise while taking Safinamide, but be cautious. This medication can cause dizziness, which might affect your balance during physical activity. To exercise safely, start with light activities and gradually increase intensity. If you feel dizzy or lightheaded, stop exercising and rest. Talk with your doctor if you have concerns about your specific situation.
Is it safe to stop Safinamide?
Stopping Safinamide suddenly can cause your symptoms to worsen. It's usually used long-term for managing Parkinson's disease, which is a chronic condition. Always talk with your doctor before stopping Safinamide. They might suggest gradually reducing your dose to avoid any potential withdrawal symptoms or worsening of your condition.
Is Safinamide addictive?
Safinamide is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Safinamide works by affecting certain chemicals in the brain to help manage symptoms of Parkinson's disease. This mechanism doesn't lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Safinamide safe for the elderly?
Elderly individuals are more vulnerable to medication side effects due to age-related changes in the body. Safinamide is generally safe for the elderly, but they may experience side effects like dizziness or high blood pressure more frequently. Regular monitoring by a healthcare provider is important to ensure safe and effective use.
What are the most common side effects of Safinamide?
Side effects are unwanted reactions to a medication. Common side effects of Safinamide include nausea and trouble sleeping. These effects vary from person to person. If you notice new symptoms after starting Safinamide, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Safinamide?
Don't take Safinamide if you're allergic to it or its ingredients. It's also contraindicated in people with severe liver problems, which affect how the body processes the medication. Caution is needed if you have a history of seizures, which are sudden bursts of electrical activity in the brain. Always consult your doctor about these concerns.
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