Rolapitant
Nausea, Vomiting
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Substance P/Neurokinin-1 Receptor Antagonist
Controlled Drug Substance
No
Rolapitant
Summary
Rolapitant is primarily used to prevent nausea and vomiting associated with chemotherapy, including highly emetogenic chemotherapy. It is often used in combination with other antiemetic agents for enhanced effectiveness.
Rolapitant works by blocking the action of neurokinin and substance P, which are natural substances in the brain that cause nausea and vomiting. It is a selective and competitive antagonist of human substance P/NK1 receptors.
For adults, the usual dose of Rolapitant is 180 mg taken as a single dose within 2 hours before chemotherapy. It is not intended for regular daily use and is typically used as a single dose before each chemotherapy cycle with a minimum interval of 14 days between doses.
Common side effects of Rolapitant include hiccups, stomach pain, decreased appetite, dizziness, and heartburn. Serious side effects may include signs of infection like fever or sore throat.
Rolapitant is contraindicated in patients taking certain medications such as thioridazine and pimozide, due to the risk of serious heart rhythm changes. It is also not recommended for children under 2 years of age due to potential developmental effects. Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.
Indications and Purpose
How does Rolapitant work?
Rolapitant works by blocking NK1 receptors in the brain, which are involved in triggering nausea and vomiting. Think of it like turning off a switch that causes these symptoms. This helps prevent nausea and vomiting during chemotherapy, improving comfort and quality of life.
Is Rolapitant effective?
Rolapitant is effective in preventing nausea and vomiting caused by chemotherapy. It works by blocking certain receptors in the brain that trigger these symptoms. Clinical studies show that Rolapitant significantly reduces the incidence of nausea and vomiting in patients undergoing chemotherapy.
What is Rolapitant?
Rolapitant is a medication used to prevent nausea and vomiting caused by chemotherapy. It works by blocking certain receptors in the brain that trigger these symptoms. Rolapitant is taken as a single dose before chemotherapy and is part of a class of drugs called NK1 receptor antagonists.
Directions for Use
For how long do I take Rolapitant?
Rolapitant is usually taken as a single dose before chemotherapy to prevent nausea and vomiting. It is not typically used for long-term treatment. Always follow your doctor's instructions regarding the duration of use for your specific treatment plan.
How do I dispose of Rolapitant?
Bring unused Rolapitant to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash.
How do I take Rolapitant?
Rolapitant is usually taken as a single dose before chemotherapy. It should be taken with or without food. Do not crush or chew the tablet. If you miss a dose, take it as soon as you remember, but do not double up on doses. Always follow your doctor's specific instructions regarding the timing and frequency of your medication.
How long does it take for Rolapitant to start working?
Rolapitant begins working shortly after you take it, with effects lasting up to 120 hours. It is taken before chemotherapy to prevent nausea and vomiting. The full benefits are usually noticed during and after chemotherapy sessions. Always take it as prescribed for the best results.
How should I store Rolapitant?
Store Rolapitant at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always keep Rolapitant out of children's reach to prevent accidental swallowing.
What is the usual dose of Rolapitant?
The usual dose of Rolapitant for adults is 180 mg taken as a single dose before chemotherapy. It is not typically adjusted for children or the elderly. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Rolapitant with other prescription drugs?
Rolapitant can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Inform your doctor about all medications you are taking to avoid potential interactions. Your doctor can help manage any interactions and adjust your treatment plan as needed.
Can Rolapitant be taken safely while breastfeeding?
The safety of Rolapitant while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you are breastfeeding or planning to breastfeed, discuss with your doctor the best treatment options for managing nausea and vomiting.
Can Rolapitant be taken safely while pregnant?
The safety of Rolapitant during pregnancy is not well-established. There is limited information on its use in pregnant women. If you are pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for managing nausea and vomiting.
Does Rolapitant have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Rolapitant include fatigue and dizziness. Serious side effects are rare but can include allergic reactions. If you experience any new or worsening symptoms, contact your doctor immediately.
Does Rolapitant have any safety warnings?
Rolapitant has important safety warnings. It may interact with other medications, so inform your doctor about all drugs you are taking. Not adhering to safety warnings can lead to increased side effects or reduced effectiveness. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Rolapitant?
It's best to avoid alcohol while taking Rolapitant. Alcohol can increase the risk of side effects like dizziness or drowsiness. If you choose to drink, limit your intake and watch for any warning signs. Talk with your doctor about alcohol use while taking Rolapitant.
Is it safe to exercise while taking Rolapitant?
You can exercise while taking Rolapitant, but be cautious. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, stay hydrated and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Rolapitant?
Rolapitant is usually taken as a single dose before chemotherapy, so there is no ongoing use to stop. If you have concerns about your treatment plan, discuss them with your doctor. They can provide guidance on any changes to your medication regimen.
Is Rolapitant addictive?
Rolapitant is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by blocking certain receptors in the brain to prevent nausea and vomiting. It doesn't affect brain chemistry in ways that could lead to addiction.
Is Rolapitant safe for the elderly?
The elderly may be more vulnerable to side effects of Rolapitant, such as dizziness or fatigue. It's important for older adults to be monitored closely while taking this medication. Always follow your doctor's advice and report any unusual symptoms.
What are the most common side effects of Rolapitant?
Side effects are unwanted reactions to a medication. Common side effects of Rolapitant include fatigue, dizziness, and hiccups. These effects vary from person to person. If you notice new symptoms after starting Rolapitant, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Rolapitant?
Do not take Rolapitant if you are allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Always inform your doctor about any allergies or other medications you are taking to avoid potential interactions.
