Rizatriptan
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Serotonin-1b and Serotonin-1d Receptor Agonist
Controlled Drug Substance
NO
Rizatriptan
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Click HereSummary
Rizatriptan is used to treat acute attacks of migraines with or without aura in adults and children aged 6 to 17 years. It's not used for preventing migraines or treating other types of headaches.
Rizatriptan works by binding to serotonin receptors in the brain. This action helps narrow blood vessels, stop pain signals, and block the release of substances that cause migraine symptoms, thus relieving the pain and other symptoms associated with migraines.
For adults, the starting dose of Rizatriptan is either 5 mg or 10 mg. For children aged 6 to 17 years, the dose is based on body weight. It should not exceed 30 mg in any 24-hour period.
Common side effects of Rizatriptan include drowsiness, dizziness, and tiredness. Serious, but rare side effects can include chest pain, shortness of breath, and serotonin syndrome.
Rizatriptan should not be used by patients with ischemic heart disease, uncontrolled hypertension, or those who have used other triptans or ergotamine within 24 hours. Caution is advised for those with cardiovascular risk factors.
Indications and Purpose
How does one know if Rizatriptan is working?
The benefit of Rizatriptan is evaluated by its ability to relieve migraine symptoms within 2 hours of administration. Patients should keep a headache diary to track the frequency and severity of headaches and the effectiveness of the medication.
How does Rizatriptan work?
Rizatriptan works by binding to serotonin receptors in the brain, which helps narrow blood vessels and block pain signals. This action reduces headache pain and associated symptoms like nausea and sensitivity to light and sound.
Is Rizatriptan effective?
Rizatriptan's effectiveness is supported by multiple clinical trials showing significant improvement in migraine symptoms compared to placebo. It reduces headache pain and associated symptoms like nausea and sensitivity to light and sound.
What is Rizatriptan?
Rizatriptan is used to treat acute migraine headaches in adults and children aged 6 to 17. It works by narrowing blood vessels in the brain and blocking pain signals, providing relief from headache pain and associated symptoms like nausea and sensitivity to light.
What is Rizatriptan used for?
Rizatriptan is indicated for the acute treatment of migraine headaches with or without aura in adults and children aged 6 to 17. It is not used for the prevention of migraines or for treating other types of headaches.
Directions for Use
For how long do I take Rizatriptan?
Rizatriptan is used to treat acute migraine attacks and is not intended for long-term use. It should not be used more than 10 days per month to avoid worsening headaches. Always follow your doctor's guidance on duration.
How do I take Rizatriptan?
Rizatriptan can be taken with or without food. However, taking it with food may delay its effect. There are no specific food restrictions, but always follow your doctor's instructions regarding medication use.
How long does it take for Rizatriptan to start working?
Rizatriptan typically starts working within 30 minutes to 2 hours after taking a dose. The time may vary depending on individual response and whether it is taken with food.
How should I store Rizatriptan?
Store Rizatriptan at room temperature, away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children. Do not store in the bathroom.
What is the usual dose of Rizatriptan?
For adults, the recommended starting dose of Rizatriptan is either 5 mg or 10 mg, with a maximum daily dose of 30 mg. For children aged 6 to 17 years, the dose is based on body weight: 5 mg for those weighing less than 40 kg (88 lb) and 10 mg for those weighing 40 kg (88 lb) or more. Always follow your doctor's instructions.
Warnings and Precautions
Can I take Rizatriptan with other prescription drugs?
Rizatriptan should not be taken with other triptans, ergot-containing drugs, or MAO inhibitors due to the risk of serious interactions. It may also interact with propranolol, requiring a dosage adjustment. Always inform your doctor of all medications you are taking.
Can Rizatriptan be taken safely while breastfeeding?
There is no data on the presence of Rizatriptan in human milk. Caution is advised, and breastfeeding mothers should consult their doctor to weigh the benefits and potential risks before using Rizatriptan.
Can Rizatriptan be taken safely while pregnant?
There is limited data on the use of Rizatriptan during pregnancy. It should only be used if the potential benefit justifies the potential risk to the fetus. Consult your doctor for personalized advice if you are pregnant or planning to become pregnant.
Is it safe to exercise while taking Rizatriptan?
Rizatriptan may cause drowsiness or dizziness, which could affect your ability to exercise safely. If you experience these side effects, it is advisable to avoid strenuous activities until you know how the medication affects you.
Is Rizatriptan safe for the elderly?
Elderly patients should use Rizatriptan with caution due to the increased risk of cardiovascular events. A lower starting dose may be recommended, and a cardiovascular evaluation might be necessary before starting treatment.
Who should avoid taking Rizatriptan?
Rizatriptan is contraindicated in patients with heart disease, uncontrolled hypertension, or a history of stroke. It should not be used with certain medications like MAO inhibitors or other triptans. Consult your doctor for a full list of contraindications.
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