Ritlecitinib
Alopecia Areata
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
No
Ritlecitinib
Summary
Ritlecitinib is used to treat alopecia areata, a condition causing sudden hair loss in adults and children aged 12 and older.
Ritlecitinib is a kinase inhibitor that works by blocking certain enzymes, specifically Janus kinase 3 (JAK3) and TEC kinase family members. This action helps reduce inflammation and immune responses that contribute to hair loss in alopecia areata. The exact mechanism of how it stops hair loss is not fully understood.
The usual daily dose of Ritlecitinib for both adults and children aged 12 years and older is 50 mg taken orally once a day. It can be taken with or without food.
Common side effects of Ritlecitinib include headache (10.8%), diarrhea (10%), acne (6.2%), and rash (5.4%).
Ritlecitinib may increase the risk of serious infections, including tuberculosis and certain cancers. It can also cause serious cardiovascular events and blood clots. Patients with active infections, a history of cancer, or cardiovascular issues should use caution.
Indications and Purpose
How does Ritlecitinib work?
Ritlecitinib is a kinase inhibitor that works by blocking certain enzymes, specifically Janus kinase 3 (JAK3) and TEC kinase family members. This action helps reduce inflammation and immune responses that contribute to hair loss in alopecia areata. The exact mechanism of how it stops hair loss is not fully understood.
Is Ritlecitinib effective?
Ritlecitinib has been evaluated in clinical trials for its effectiveness in treating alopecia areata, a condition causing severe hair loss. In these trials, a significant number of patients experienced hair regrowth, as measured by the Severity of Alopecia Tool (SALT) score. The trials demonstrated that Ritlecitinib can help reduce scalp hair loss in patients with alopecia areata.
What is Ritlecitinib?
Ritlecitinib is used to treat alopecia areata, a condition causing sudden hair loss in adults and children aged 12 and older. It belongs to a class of medications called kinase inhibitors, which work by affecting certain enzymes in the body. This action helps reduce hair loss, although the exact mechanism is not fully understood.
Directions for Use
For how long do I take Ritlecitinib?
The typical duration of use for Ritlecitinib is not specified in the provided content. Treatment duration may vary based on individual response and medical advice. Always follow your doctor's guidance regarding how long to take this medication.
How do I take Ritlecitinib?
Ritlecitinib should be taken once daily, with or without food, at the same time each day. Swallow the capsules whole without crushing, splitting, or chewing them. There are no specific food restrictions mentioned, but always follow your doctor's advice.
How should I store Ritlecitinib?
Store Ritlecitinib at room temperature between 68°F to 77°F (20°C to 25°C). Keep it in its original container, tightly closed, and away from excess heat and moisture. Ensure it is out of reach of children and do not store it in the bathroom.
What is the usual dose of Ritlecitinib?
The usual daily dose of Ritlecitinib for both adults and children aged 12 years and older is 50 mg taken orally once a day. It can be taken with or without food. Always follow your doctor's instructions regarding dosage.
Warnings and Precautions
Can I take Ritlecitinib with other prescription drugs?
Ritlecitinib can interact with CYP3A and CYP1A2 substrates, potentially increasing the risk of adverse reactions. It is not recommended to use Ritlecitinib with strong CYP3A inducers like rifampin, as they may reduce its effectiveness. Always discuss all medications with your doctor before starting Ritlecitinib.
Can Ritlecitinib be taken safely while breastfeeding?
It is not known if Ritlecitinib passes into breast milk. Due to potential serious adverse effects, women are advised not to breastfeed during treatment and for 14 hours after the last dose. Consult your healthcare provider for personalized advice.
Can Ritlecitinib be taken safely while pregnant?
There is limited data on the use of Ritlecitinib during pregnancy. Animal studies have shown potential risks, so it is advised to avoid using Ritlecitinib if you are pregnant or planning to become pregnant. Always consult your healthcare provider for personalized advice.
Is Ritlecitinib safe for the elderly?
Elderly patients should use Ritlecitinib with caution due to a higher incidence of infections in this population. No specific dose adjustment is required for patients aged 65 and older, but close monitoring is advised. Always consult a healthcare provider for personalized advice.
Who should avoid taking Ritlecitinib?
Ritlecitinib may increase the risk of serious infections, including tuberculosis, and certain cancers. It can also cause serious cardiovascular events and blood clots. Patients with active infections, a history of cancer, or cardiovascular issues should use caution. Regular monitoring and communication with a healthcare provider are essential.
