Rimegepant
Migraine with Aura, Migraine without Aura ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Calcitonin Gene-related Peptide Receptor Antagonist
Controlled Drug Substance
No
Rimegepant
Summary
Rimegepant is used to treat and prevent migraine headaches in adults. Migraine is a severe throbbing headache that may be accompanied by nausea and sensitivity to light or sound.
Rimegepant works by blocking the action of a natural substance in the body called calcitonin gene-related peptide (CGRP) that causes migraines. By blocking these receptors, it helps to reduce the pain and other symptoms associated with migraines.
For acute migraine treatment, Rimegepant is taken orally as a 75 mg disintegrating tablet as needed, with a maximum of one dose in a 24-hour period. For preventive treatment of episodic migraine, it is 75 mg taken every other day.
The most frequently reported side effect of Rimegepant is nausea, occurring in about 2% of patients. Serious adverse effects include hypersensitivity reactions such as shortness of breath, difficulty breathing, and swelling of the face, eyes, mouth, throat, tongue, or lips.
Rimegepant should not be used by patients with a history of hypersensitivity reactions to the drug. These reactions can include difficulty breathing and rash, and can occur days after administration. Rimegepant should also be used cautiously in patients with severe hepatic impairment and is not recommended for those with end-stage renal disease.
Indications and Purpose
How does Rimegepant work?
Rimegepant works by blocking the calcitonin gene-related peptide (CGRP) receptor, which is involved in the development of migraine headaches. By inhibiting this receptor, Rimegepant helps prevent the onset of migraines and reduces their severity.
Is Rimegepant effective?
Rimegepant's effectiveness was demonstrated in clinical trials for both acute and preventive treatment of migraines. In a study, 21.2% of patients achieved pain freedom at 2 hours compared to 10.9% with placebo. For prevention, it reduced monthly migraine days by 0.8 days more than placebo.
What is Rimegepant?
Rimegepant is used to treat and prevent migraine headaches in adults. It works by blocking the action of a natural substance in the body that causes migraines, known as calcitonin gene-related peptide (CGRP). This helps reduce the frequency and severity of migraine attacks.
Directions for Use
For how long do I take Rimegepant?
Rimegepant can be used as needed for acute migraine attacks, with a maximum of 18 doses in a 30-day period. For preventive treatment, it is taken every other day. The duration of use should be determined by a healthcare provider based on individual needs.
How do I take Rimegepant?
Rimegepant is taken as an orally disintegrating tablet that dissolves in the mouth. It can be taken with or without food. No specific food restrictions are necessary, but it should be taken as directed by a healthcare provider.
How long does it take for Rimegepant to start working?
Rimegepant typically starts working within 1.5 hours after oral administration, as it is absorbed into the bloodstream. Its effectiveness in relieving migraine symptoms can be observed within this timeframe.
How should I store Rimegepant?
Store Rimegepant in its original container, tightly closed, at room temperature, away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Rimegepant?
For adults, the recommended dose of Rimegepant for acute migraine treatment is 75 mg taken orally as needed, with a maximum of one dose in a 24-hour period. For preventive treatment of episodic migraine, it is 75 mg taken every other day. Safety and effectiveness in children have not been established.
Warnings and Precautions
Can I take Rimegepant with other prescription drugs?
Avoid using Rimegepant with strong CYP3A4 inhibitors, as they increase rimegepant exposure. Also, avoid using it with strong or moderate CYP3A inducers, which can reduce its effectiveness. Avoid another dose within 48 hours if taken with moderate CYP3A4 inhibitors or potent P-gp inhibitors.
Can Rimegepant be taken safely while breastfeeding?
Rimegepant passes into breast milk in very small amounts. The developmental and health benefits of breastfeeding should be considered along with the mother's need for Rimegepant. Consult a healthcare provider to weigh the benefits and potential risks.
Can Rimegepant be taken safely while pregnant?
There is a pregnancy exposure registry to monitor outcomes in women using Rimegepant during pregnancy. No adequate data on developmental risks in humans are available. Animal studies showed adverse effects at high doses. Consult a healthcare provider for personalized advice if pregnant or planning to become pregnant.
Is Rimegepant safe for the elderly?
Clinical studies did not include enough patients aged 65 and over to determine if they respond differently from younger patients. However, no significant pharmacokinetic differences were observed between elderly and younger subjects. Elderly patients should use Rimegepant under the guidance of a healthcare provider.
Who should avoid taking Rimegepant?
Rimegepant is contraindicated in patients with a history of hypersensitivity to the drug or its components. Serious hypersensitivity reactions, including dyspnea and rash, have been reported. If such reactions occur, discontinue use and seek medical attention immediately.
