Ribociclib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Ribociclib
Summary
Ribociclib is used to treat certain types of breast cancer, specifically hormone receptor-positive, HER2-negative breast cancer in both postmenopausal and some premenopausal women. It's usually prescribed when the cancer is advanced or has spread to other parts of the body.
Ribociclib works by blocking proteins called cyclin-dependent kinases (CDK4/6). These proteins help cancer cells grow uncontrollably. By stopping these proteins, Ribociclib slows down or stops the growth of cancer cells.
The usual adult dose is 600 mg once daily for 21 days, followed by a 7-day break. This 28-day cycle is repeated. Ribociclib is taken orally, with or without food. It's usually taken in combination with hormonal therapy like letrozole.
Common side effects include nausea, fatigue, diarrhea, hair thinning, and low white blood cell count which can increase the risk of infection. Some patients may also experience mood changes, loss of appetite, sleep disturbances, headaches, and stomach pain.
Ribociclib should not be taken if you have serious liver disease, heart problems, or an active infection. It's also not safe for pregnant women as it can harm the baby. Be sure to inform your doctor about all medicines and supplements you take, as some can interact with Ribociclib and reduce its effectiveness.
Indications and Purpose
How does Ribociclib work?
It blocks CDK4/6 proteins, which control cell division. By stopping these proteins, it prevents cancer cells from multiplying, slowing tumor growth.
Is Ribociclib effective?
Clinical studies show that Ribociclib significantly improves survival and slows cancer progression when combined with hormone therapy. Patients using it have longer periods without disease worsening compared to those taking hormonal therapy alone.
What is Ribociclib?
Ribociclib is a targeted cancer medicine used to treat certain types of breast cancer. It works by blocking proteins called cyclin-dependent kinases (CDK4/6), which help cancer cells grow uncontrollably. By stopping these proteins, Ribociclib slows down or stops the growth of cancer cells. It is often used with hormonal therapy for postmenopausal women and some premenopausal women with hormone receptor-positive, HER2-negative breast cancer.
Directions for Use
For how long do I take Ribociclib?
You will take Ribociclib in cycles, with 21 days on and 7 days off. The total duration depends on how well your cancer responds and whether you experience serious side effects. Your doctor will monitor your progress and decide if you should continue.
How do I take Ribociclib?
Take Ribociclib once daily at the same time each day, with or without food. Swallow the tablets whole; do not crush, chew, or split them. Avoid grapefruit and grapefruit juice as they can affect how the medicine works. If you miss a dose, do not take an extra one; just take the next dose at the regular time.
How long does it take for Ribociclib to start working?
Ribociclib starts working within a few weeks, but noticeable improvements usually appear after several months of treatment. Doctors monitor its effects through blood tests and imaging scans.
How should I store Ribociclib?
Store at room temperature (20–25°C), away from moisture and heat. Keep it in the original container and out of reach of children.
What is the usual dose of Ribociclib?
The usual adult dose is 600 mg once daily for 21 days, followed by a 7-day break in a 28-day cycle. It is taken in combination with hormone therapy like letrozole. The dose may be adjusted if side effects occur. It is not usually prescribed for children since its safety and effectiveness in pediatric patients are not well established.
Warnings and Precautions
Can I take Ribociclib with other prescription drugs?
Some drugs, like certain antibiotics, antifungals, and seizure medications, may interact with Ribociclib, reducing its effect or increasing side effects. Always inform your doctor about all medicines you take.
Can Ribociclib be taken safely while breastfeeding?
No. Do not breastfeed while taking ribociclib, and for at least 3 weeks after your final dose. Ribociclib may harm the breastfed infant. Studies in rats have shown that ribociclib levels in breast milk are much higher than in the mother's blood.
Can Ribociclib be taken safely while pregnant?
No, Ribociclib is unsafe in pregnancy as it may cause serious harm to the fetus. Women of childbearing age should use effective birth control while taking this medicine and for at least three weeks after stopping it. If pregnancy occurs, contact a doctor immediately.
Is it safe to drink alcohol while taking Ribociclib?
Drinking alcohol while on ribociclib is not recommended, as both alcohol and the medicine can strain the liver and increase the risk of liver damage. Alcohol may also worsen dizziness, fatigue, and nausea, making side effects harder to manage. If you choose to drink, limit intake and consult your doctor about safe amounts. It’s best to prioritize your health over alcohol consumption.
Is it safe to exercise while taking Ribociclib?
Yes, light to moderate exercise is generally safe while taking ribociclib, and it may even help manage fatigue and stress. However, patients should avoid strenuous activities if experiencing severe weakness, dizziness, or low blood cell counts. Walking, yoga, and light stretching are good options. Always listen to your body, and consult your doctor before starting any intense workouts.
Is Ribociclib safe for the elderly?
Yes, but older adults may require closer monitoring for liver and heart-related side effects. Dose adjustments may be necessary if severe reactions occur.
Who should avoid taking Ribociclib?
Avoid it if you have serious liver disease, heart problems, or an active infection. Pregnant women should not take it as it can harm the baby.
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