Procarbazine
Hodgkin Disease, Non-Hodgkin Lymphoma ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Alkylating Drug
Controlled Drug Substance
No
Procarbazine
Summary
Procarbazine is primarily used to treat Hodgkin's lymphoma and certain brain tumors such as gliomas.
Procarbazine is an alkylating agent. It works by damaging the DNA of cancer cells, which prevents them from dividing and growing. This helps to slow down the progression of the tumor and reduces the spread of cancer.
Procarbazine is taken orally, with or without food. The usual dose for adults varies, but typically starts at 50 mg/day and increases gradually. For children, the dose is based on body weight and is determined by the doctor.
Common side effects of Procarbazine include nausea, vomiting, loss of appetite, fatigue, dizziness, and low blood counts.
Procarbazine should not be taken by people with severe liver or kidney disease, bone marrow suppression, or allergy to Procarbazine. It is also contraindicated in those taking MAO inhibitors due to the risk of dangerous drug interactions.
Indications and Purpose
How does Procarbazine work?
Procarbazine is an alkylating agent that damages the DNA of cancer cells, preventing them from dividing and growing. This ultimately slows tumor progression and reduces cancer spread.
Is Procarbazine effective?
Yes, Procarbazine is effective when used in combination therapy for Hodgkin’s lymphoma and brain tumors. Clinical studies show that it improves survival rates when used with other chemotherapy drugs like mechlorethamine, vincristine, and prednisone (MOPP regimen).
What is Procarbazine?
Procarbazine is a chemotherapy drug used mainly to treat Hodgkin’s lymphoma and certain brain tumors. It works by interfering with cancer cell growth and preventing them from multiplying. This medicine is often used in combination with other cancer drugs to improve effectiveness.
Directions for Use
For how long do I take Procarbazine?
The duration of treatment depends on the type of cancer and response to therapy. It is usually given in cycles over several weeks or months. Your doctor will monitor progress and decide when to stop or adjust the treatment.
How do I take Procarbazine?
Procarbazine is taken orally with or without food. It is important to swallow the capsule whole with water. Avoid alcohol and foods high in tyramine (aged cheese, cured meats, fermented foods) as they can cause serious side effects like high blood pressure.
How long does it take for Procarbazine to start working?
Procarbazine starts affecting cancer cells within days to weeks, but visible improvement depends on the type and stage of cancer. Regular blood tests and scans help doctors track the response to treatment over time.
How should I store Procarbazine?
Store Procarbazine at room temperature (20-25°C), away from heat, moisture, and direct light. Keep it out of reach of children and dispose of expired medicine properly.
What is the usual dose of Procarbazine?
The usual dose for adults varies depending on the condition, but it typically starts at 50 mg/day and increases gradually. For children, dosing is based on body weight and is determined by the doctor. Always follow your oncologist’s instructions carefully.
Warnings and Precautions
Can I take Procarbazine with other prescription drugs?
Procarbazine interacts with antidepressants (MAO inhibitors, SSRIs), sedatives, blood thinners, and some chemotherapy drugs. These interactions can increase the risk of serious side effects. Inform your doctor about all medications you take.
Can Procarbazine be taken safely while breastfeeding?
No, Procarbazine may pass into breast milk and harm the baby. Breastfeeding is not recommended during treatment. Discuss alternative feeding options with your doctor.
Can Procarbazine be taken safely while pregnant?
No, Procarbazine is not safe during pregnancy, as it can cause birth defects and harm fetal development. Women should use effective birth control during treatment. If pregnancy occurs, consult your doctor immediately.
Is it safe to drink alcohol while taking Procarbazine?
No, alcohol should be avoided, as it can cause severe nausea, vomiting, dizziness, and dangerous interactions. Combining alcohol with Procarbazine may also increase the risk of high blood pressure.
Is it safe to exercise while taking Procarbazine?
Light to moderate exercise is usually safe, but avoid intense workouts if you feel fatigued or dizzy. Listen to your body and rest as needed. Consult your doctor before starting or continuing an exercise routine.
Is Procarbazine safe for the elderly?
Elderly patients may be more prone to bone marrow suppression, infections, and neurological side effects. Close monitoring is required to adjust dosage and manage side effects properly.
Who should avoid taking Procarbazine?
People with severe liver or kidney disease, bone marrow suppression, or allergy to Procarbazine should avoid it. It is also contraindicated in those taking MAO inhibitors, as it can cause dangerous drug interactions.
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