Pravastatin
Coronary Artery Disease, Hypercholesterolemia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
HMG-CoA Reductase Inhibitor
Controlled Drug Substance
No
Pravastatin
Summary
Pravastatin is used to lower cholesterol levels, reduce the risk of heart disease, stroke, and heart attacks, and prevent cardiovascular problems in people with high cholesterol or diabetes. It's also used in people with a history of heart disease to prevent further complications.
Pravastatin works by blocking HMG-CoA reductase, an enzyme needed to make cholesterol in the liver. This helps lower bad LDL cholesterol and triglycerides while increasing good HDL cholesterol, reducing the risk of heart attacks and strokes.
For adults, the usual starting dose is 10-40 mg once daily. The maximum dose is 80 mg daily. In children 8-13 years, the dose ranges from 10-20 mg daily while adolescents 14-18 years may take up to 40 mg daily. The doctor adjusts the dose based on cholesterol levels and individual needs.
Common side effects include headache, nausea, muscle pain, diarrhea, and dizziness. Rare but serious side effects include liver problems and muscle breakdown (rhabdomyolysis), which can cause severe weakness and kidney damage.
People with liver disease, severe kidney disease, or an allergy to pravastatin should avoid this medication. Pregnant and breastfeeding women should not take pravastatin as it may harm the baby. Those with a history of muscle disorders should consult their doctor before use.
Indications and Purpose
How does Pravastatin work?
Pravastatin inhibits HMG-CoA reductase, an enzyme in the liver responsible for cholesterol production. By blocking this enzyme, it reduces the amount of cholesterol made by the liver, lowering LDL (bad cholesterol), increasing HDL (good cholesterol), and reducing triglycerides, ultimately decreasing the risk of cardiovascular diseases.
Is Pravastatin effective?
Yes, studies show that pravastatin effectively lowers cholesterol and reduces the risk of heart disease, strokes, and heart attacks. It is especially useful for people with high cholesterol, diabetes, or a history of cardiovascular disease. Long-term use improves overall heart health and prevents complications.
What is Pravastatin?
Pravastatin is a statin medication used to lower cholesterol levels and reduce the risk of heart disease. It works by blocking HMG-CoA reductase, an enzyme needed to make cholesterol in the liver. This helps lower "bad" LDL cholesterol and triglycerides while increasing "good" HDL cholesterol, reducing the risk of heart attacks and strokes.
Directions for Use
For how long do I take Pravastatin?
Pravastatin is usually taken long-term or lifelong, as stopping it may cause cholesterol levels to rise again, increasing the risk of heart disease or stroke. Your doctor will monitor your progress and may adjust the dosage over time. Regular cholesterol checks will help determine if you need to continue.
How do I take Pravastatin?
Pravastatin is taken once daily, preferably in the evening, with or without food. It is important to take it at the same time every day for the best effect. Avoid eating grapefruit or drinking grapefruit juice, as it may interfere with the medication. Always follow your doctor’s instructions.
How long does it take for Pravastatin to start working?
Pravastatin starts working within a few days, but noticeable cholesterol reduction usually takes 2 to 4 weeks. However, full benefits, such as reduced heart disease risk, may take several months. Regular blood tests are needed to monitor progress.
How should I store Pravastatin?
Store pravastatin at room temperature (15-30°C) in a dry place away from heat, moisture, and direct sunlight. Keep it in its original container with the lid tightly closed. Do not store in the bathroom. Keep it out of reach of children.
What is the usual dose of Pravastatin?
For adults, the usual starting dose is 10–40 mg once daily. The maximum dose is 80 mg daily. In children (8–13 years), the dose ranges from 10–20 mg daily, while adolescents (14–18 years) may take up to 40 mg daily. The doctor adjusts the dose based on cholesterol levels and individual needs.
Warnings and Precautions
Can I take Pravastatin with other prescription drugs?
Pravastatin may interact with certain antibiotics, antifungal drugs, blood thinners, and other cholesterol-lowering medications. Some medications increase the risk of muscle damage. Always inform your doctor about all medications you are taking to avoid harmful interactions.
Can Pravastatin be taken safely while breastfeeding?
No, pravastatin should not be used while breastfeeding because it may pass into breast milk and affect the baby. Women taking pravastatin should switch to formula or consult a doctor for alternative cholesterol treatments.
Can Pravastatin be taken safely while pregnant?
No, pravastatin should not be taken during pregnancy, as it may harm the baby’s development. If you become pregnant while taking it, stop the medication immediately and consult your doctor for alternative treatments.
Is it safe to drink alcohol while taking Pravastatin?
Moderate alcohol consumption is generally safe, but excessive drinking can increase the risk of liver damage while on pravastatin. If you drink, limit intake to one drink per day for women and two for men. Always consult your doctor if you have liver concerns.
Is it safe to exercise while taking Pravastatin?
Yes, regular exercise is recommended while taking pravastatin. However, if you experience muscle pain or weakness, stop exercising and consult your doctor, as it may be a sign of muscle breakdown (rhabdomyolysis). Start with moderate activities like walking or yoga before progressing to intense workouts.
Is Pravastatin safe for the elderly?
Yes, pravastatin is generally safe for elderly patients, but they may be at a higher risk of muscle pain and liver problems. Doctors may start with a lower dose and monitor them more frequently for side effects.
Who should avoid taking Pravastatin?
People with liver disease, severe kidney disease, or an allergy to pravastatin should avoid this medication. Pregnant and breastfeeding women should not take pravastatin, as it may harm the baby. Those with a history of muscle disorders should consult their doctor before use.
