Pomalidomide
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Thalidomide Analog
Controlled Drug Substance
NO
Pomalidomide
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Click HereSummary
Pomalidomide is used to treat multiple myeloma and Kaposi's sarcoma, especially in patients who have not responded to other treatments.
Pomalidomide works by modulating the immune system, helping the bone marrow produce normal blood cells and killing abnormal cells.
For adults, the usual dose of Pomalidomide is 4 mg taken once daily on days 1 to 21 of a 28-day cycle. For Kaposi Sarcoma, the dose is 5 mg once daily on the same schedule.
Common side effects of Pomalidomide include fatigue, nausea, diarrhea, and constipation. Serious adverse effects can include blood clots, heart attacks, and strokes.
Pomalidomide can cause severe birth defects and is contraindicated in pregnancy. It may also increase the risk of blood clots, heart attacks, and strokes. Patients should not donate blood or sperm while on this medication.
Indications and Purpose
What is Pomalidomide used for?
Pomalidomide is indicated for the treatment of multiple myeloma in patients who have not responded to other treatments, and for Kaposi's sarcoma, particularly in those with AIDS-related or HIV-negative forms of the disease. It is used when other medications have been unsuccessful.
How does Pomalidomide work?
Pomalidomide works by modulating the immune system, helping the bone marrow produce normal blood cells, and killing abnormal cells. It targets specific proteins for degradation, leading to direct cytotoxic and immunomodulatory effects, which help in treating conditions like multiple myeloma.
Is Pomalidomide effective?
Pomalidomide is proven effective in treating multiple myeloma and Kaposi's sarcoma, particularly in patients who have not responded to other treatments. Clinical trials have shown that it helps in producing normal blood cells and killing abnormal cells, improving patient outcomes.
How does one know if Pomalidomide is working?
The benefit of Pomalidomide is evaluated through regular doctor visits and laboratory tests to monitor the body's response. These assessments help determine the effectiveness of the treatment and guide any necessary adjustments to the medication regimen.
Directions for Use
What is the usual dose of Pomalidomide?
For adults, the usual dose of Pomalidomide is 4 mg taken once daily on days 1 to 21 of a 28-day cycle. For Kaposi Sarcoma, the dose is 5 mg once daily on the same schedule. The safety and effectiveness of Pomalidomide in children have not been established, so there is no recommended dose for pediatric patients.
How do I take Pomalidomide?
Pomalidomide should be taken once daily, with or without food, at the same time each day. Swallow the capsules whole with water, and do not break or chew them. There are no specific food restrictions, but always follow your doctor's advice regarding diet and medication.
For how long do I take Pomalidomide?
Pomalidomide is typically used until disease progression or unacceptable toxicity occurs. The duration can vary based on individual response and tolerance to the medication.
How long does it take for Pomalidomide to start working?
The time it takes for Pomalidomide to start working can vary based on individual response and the condition being treated. Patients should follow their doctor's guidance and attend regular check-ups to monitor the effectiveness of the treatment.
How should I store Pomalidomide?
Store Pomalidomide in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and return any unused medication to your pharmacy or manufacturer for proper disposal.
Warnings and Precautions
Who should avoid taking Pomalidomide?
Pomalidomide can cause severe birth defects and is contraindicated in pregnancy. It may also increase the risk of blood clots, heart attacks, and strokes. Patients should not donate blood or sperm while on this medication. Regular monitoring and adherence to the Pomalyst REMS program are essential.
Can I take Pomalidomide with other prescription drugs?
Pomalidomide may interact with strong CYP1A2 inhibitors, which can increase its levels in the body. Patients should inform their doctor about all medications they are taking to avoid potential interactions. Adjustments to Pomalidomide dosage may be necessary when taken with certain drugs.
Can I take Pomalidomide with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Pomalidomide be taken safely while pregnant?
Pomalidomide is contraindicated during pregnancy due to the risk of severe birth defects. Women of childbearing potential must use two forms of contraception and undergo regular pregnancy testing. There is strong evidence from human studies that Pomalidomide can cause fetal harm.
Can Pomalidomide be taken safely while breastfeeding?
Breastfeeding is not recommended while taking Pomalidomide, as it is unknown if the drug passes into breast milk and could harm a nursing infant. Women should discuss alternative feeding options with their healthcare provider.
Is Pomalidomide safe for the elderly?
Elderly patients may be more susceptible to side effects of Pomalidomide, such as fatigue and dizziness. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Dose adjustments may be necessary based on individual tolerance and response.
Is it safe to exercise while taking Pomalidomide?
Pomalidomide may cause fatigue and dizziness, which could limit your ability to exercise. If you experience these side effects, it's important to discuss them with your doctor. They can provide guidance on safe levels of physical activity while taking this medication.
Is it safe to drink alcohol while taking Pomalidomide?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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