Plecanatide
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Guanylate Cyclase-C Agonist
Controlled Drug Substance
No
Plecanatide
Summary
Plecanatide is used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBSC). These conditions involve difficulty in bowel movement and related discomfort.
Plecanatide works by mimicking a natural substance in your intestines. It increases fluid secretion in the intestines, making your bowel movements easier and relieving constipation.
The typical dose for adults is 3 mg once daily. You can take Plecanatide with or without food. You can swallow the tablet whole or dissolve it in water if you have difficulty swallowing.
The most common side effects of Plecanatide are diarrhea, nausea, gas, and abdominal discomfort. Severe dehydration is a rare but serious risk. If you experience these side effects, you should consult your doctor.
Plecanatide is not approved for use in children under 6 years of age due to risks of severe dehydration. It should not be used by people with known or suspected bowel blockages. Always consult your doctor before using Plecanatide if you are pregnant, breastfeeding, or taking other medications.
Indications and Purpose
How does Plecanatide work?
Plecanatide works by activating guanylate cyclase-C receptors in the intestines, which increases fluid secretion and speeds up bowel movements. Think of it like adding water to a dry sponge, making it easier to pass. This helps relieve symptoms of chronic idiopathic constipation.
Is Plecanatide effective?
Plecanatide is effective for treating chronic idiopathic constipation, which is a condition where bowel movements are infrequent or difficult without a known cause. Clinical studies show Plecanatide improves bowel movement frequency and stool consistency. It works by increasing fluid in the intestines, which helps ease stool passage.
What is Plecanatide?
Plecanatide is a medication used to treat chronic idiopathic constipation, which is a condition where bowel movements are infrequent or difficult without a known cause. It belongs to a class of drugs called guanylate cyclase-C agonists, which work by increasing fluid in the intestines to help ease stool passage.
Directions for Use
For how long do I take Plecanatide?
Plecanatide is usually a long-term medication for managing chronic idiopathic constipation. You'll typically take Plecanatide every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Plecanatide treatment.
How do I dispose of Plecanatide?
If you can, bring unused Plecanatide to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Plecanatide?
Take Plecanatide once daily, with or without food. Swallow the tablet whole; do not crush it. If you miss a dose, take it when you remember unless it's almost time for your next dose. Then skip the missed dose and continue your normal schedule. Never take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Plecanatide to start working?
Plecanatide usually starts working within a few days to improve bowel movements. However, the full therapeutic effect may take a week or more. Individual factors like diet, hydration, and overall health can affect how quickly you notice improvements. Take it exactly as prescribed for the best results.
How should I store Plecanatide?
Store Plecanatide at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always store Plecanatide out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Plecanatide?
The usual starting dose of Plecanatide for adults is 3 mg once daily. It should be taken with or without food. There are no specific dose adjustments for special populations like children or the elderly. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Plecanatide with other prescription drugs?
There are no major or moderate drug interactions specifically associated with Plecanatide. However, always inform your doctor about all the medications you are taking to avoid any potential interactions. This helps ensure your treatment is safe and effective.
Can Plecanatide be taken safely while breastfeeding?
There is limited information on the safety of Plecanatide while breastfeeding. It's not known if Plecanatide is excreted into breast milk. If you're taking Plecanatide and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Plecanatide be taken safely while pregnant?
There is limited evidence on the safety of Plecanatide during pregnancy. It's important to weigh the benefits and risks with your doctor. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition during this important time.
Does Plecanatide have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Plecanatide include diarrhea, which affects more than 10% of users. Serious side effects are rare but can include severe dehydration. If you experience severe diarrhea or dehydration, contact your doctor immediately. Always inform your doctor about any new or worsening symptoms.
Does Plecanatide have any safety warnings?
Plecanatide has important safety warnings. It is not recommended for children under 6 years due to the risk of serious dehydration. In older children, use only if the benefits outweigh the risks. If you experience severe diarrhea, stop taking Plecanatide and contact your doctor. Not adhering to these warnings can lead to serious health issues.
Is it safe to drink alcohol while taking Plecanatide?
There are no well-established interactions between Plecanatide and alcohol. However, alcohol can cause dehydration, which may worsen side effects like diarrhea. If you choose to drink, do so in moderation and stay hydrated. Talk with your doctor about alcohol use while taking Plecanatide for personalized advice.
Is it safe to exercise while taking Plecanatide?
You can exercise while taking Plecanatide, but be aware of potential side effects like diarrhea, which can cause dehydration. This might make you feel dizzy during exercise. To exercise safely, drink plenty of water before, during, and after physical activity. If you notice symptoms like dizziness, slow down or stop exercising and rest.
Is it safe to stop Plecanatide?
Plecanatide is used for chronic conditions like constipation. Stopping it suddenly may cause your symptoms to return. There are no known withdrawal symptoms, but always talk with your doctor before stopping Plecanatide. They can help you make any medication changes safely to protect your health.
Is Plecanatide addictive?
Plecanatide is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Plecanatide doesn't carry this risk.
Is Plecanatide safe for the elderly?
The elderly may be more vulnerable to dehydration, which is a risk with Plecanatide due to its side effect of diarrhea. It's important for elderly users to stay hydrated and monitor for signs of dehydration. Always consult with a doctor to ensure Plecanatide is safe for elderly patients.
What are the most common side effects of Plecanatide?
Side effects are unwanted reactions that can happen when taking a medication. The most common side effect of Plecanatide is diarrhea, affecting more than 10% of users. If you notice new symptoms after starting Plecanatide, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Plecanatide?
Plecanatide should not be used in children under 6 years due to the risk of serious dehydration. It is also contraindicated in patients with known or suspected mechanical gastrointestinal obstruction, which is a blockage in the intestines. Always consult your doctor about these concerns.
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