Piroxicam
Rheumatoid Arthritis, Ankylosing Spondylitis ... show more
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
NO

Piroxicam
Summary
Piroxicam is a medication used to treat pain and inflammation caused by conditions like osteoarthritis and rheumatoid arthritis. These conditions cause pain, swelling, and stiffness in the joints.
Piroxicam works by blocking the production of certain chemicals in the body that cause inflammation and pain. It reduces pain and swelling in conditions like arthritis.
The usual dosage of Piroxicam is 20mg once daily, taken by mouth. It's recommended to take it at the same time each day. The medication may take up to 12 days to work effectively.
Common side effects of Piroxicam include swelling, stomach pain, constipation, dizziness, and rash. Serious side effects can include increased risk of heart attack, stroke, liver failure, kidney failure, and life-threatening allergic reactions.
Piroxicam can increase your risk of heart attack and stroke, especially if taken for a long time or at high doses. It can also cause ulcers and bleeding in your stomach or intestines. Do not take Piroxicam before or after heart surgery, or for conditions it's not prescribed for.
Indications and Purpose
How does Piroxicam work?
Piroxicam reduces pain by blocking the production of prostaglandins, which are chemicals that make pain worse. Prostaglandins also cause inflammation, so piroxicam's pain-relieving effects may also be due to its ability to reduce inflammation.
Is Piroxicam effective?
Piroxicam has been shown to be effective in reducing pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders. Clinical trials have demonstrated that Piroxicam effectively alleviates pain, decreases swelling, and improves joint function. Its long duration of action helps provide sustained symptom relief, making it useful for chronic inflammatory conditions.
What is Piroxicam?
Piroxicam is a medicine that helps reduce pain, swelling, and stiffness caused by conditions like arthritis. It works by blocking the production of chemicals in the body that cause inflammation and pain.
Directions for Use
For how long do I take Piroxicam?
For best results, use the lowest dose of NSAIDs that works for you and only for as long as needed. If you're taking piroxicam and are more than 20 weeks pregnant, your doctor may want to check your baby's amniotic fluid levels with an ultrasound after 48 hours. If the fluid levels are low (oligohydramnios), stop taking piroxicam.
How do I dispose of Piroxicam?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Piroxicam?
Piroxicam is typically taken once daily, with or without food. However, it is recommended to take it with food or milk to reduce the risk of stomach irritation or ulcers. People taking Piroxicam should avoid alcohol, as it may increase the risk of gastrointestinal bleeding. It's also important to follow dosing instructions provided by your doctor and not exceed the prescribed dose.
How long does it take for Piroxicam to start working?
Piroxicam is a medication that takes time to work fully. While you may notice some improvement early on, it can take up to two weeks for the full effects to be felt. This is why it's important to avoid making any judgments about the medication's effectiveness before that two-week mark.
How should I store Piroxicam?
Piroxicam should be stored at room temperature, away from moisture and heat. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom, as humidity can affect the medication's effectiveness. Always check the expiration date and properly dispose of any expired or unused medicine.
What is the usual dose of Piroxicam?
For adults with rheumatoid or osteoarthritis, the typical daily dose of Piroxicam is 20 mg, taken by mouth. You may take the dose all at once or divide it into smaller doses throughout the day. It takes about 7-12 days for Piroxicam to reach its full effect in your body, so you may not notice the full benefits right away. Piroxicam has not been studied in children, so it is not recommended for use in this population.
Warnings and Precautions
Can I take Piroxicam with other prescription drugs?
Piroxicam can interact with several medications, increasing the risk of side effects. Key interactions include:
- Anticoagulants (e.g., warfarin): Increased bleeding risk.
- Other NSAIDs: Risk of gastrointestinal bleeding or ulceration.
- Antihypertensives (e.g., ACE inhibitors, diuretics): Reduced effectiveness of blood pressure medications.
- Corticosteroids: Increased risk of gastrointestinal issues. Always consult a healthcare provider before using Piroxicam with other medications.
Can Piroxicam be taken safely while breastfeeding?
Piroxicam is excreted in breast milk in small amounts. While there are no conclusive studies on its effects in nursing infants, it is recommended to avoid using Piroxicam during breastfeeding, especially in newborns or premature infants, due to potential risks like gastrointestinal bleeding or renal impairment. It's advisable to consult a healthcare provider for alternatives if breastfeeding.
Can Piroxicam be taken safely while pregnant?
Piroxicam is classified as a Category D drug during pregnancy, indicating potential risks to the fetus. It can cause premature closure of the ductus arteriosus, a critical blood vessel in the fetus, and may lead to renal impairment or pulmonary hypertension in the newborn. It is generally advised to avoid using Piroxicam, especially in the third trimester, unless absolutely necessary. Always consult a healthcare provider before use during pregnancy.
Does Piroxicam have adverse effects?
Adverse effects, which are unwanted or harmful reactions to a medicine, can occur with any medication. For this medicine, common adverse effects might include nausea, headache, dizziness, fatigue, and dry mouth. These effects can vary in frequency, with some people experiencing them more often than others. Rare but serious adverse effects could include severe allergic reactions, which might cause difficulty breathing or swelling of the face and throat, and require immediate medical attention. It's crucial to report any new or worsening symptoms to a healthcare provider. Never stop taking a medicine without consulting a healthcare professional, as they can provide guidance on managing side effects or adjusting treatment.
Does Piroxicam have any safety warnings?
To determine if a medicine has safety warnings, you should first check the prescription information provided with the medicine. This information often includes a section on safety warnings. For example, if a medicine has a warning about causing drowsiness, the rationale is that it can impair your ability to drive or operate machinery, leading to accidents. The possible consequence is injury to yourself or others. To guard against this, monitor for signs of drowsiness, such as feeling unusually sleepy or having difficulty staying awake. If you experience these symptoms, avoid activities that require full alertness. Always consult with a healthcare professional for personalized advice.
Is it safe to drink alcohol while taking Piroxicam?
Drinking alcohol while taking these medicines can make stomach problems worse. It is unknown if drinking in moderation affects how well this medicine works.
Is it safe to exercise while taking Piroxicam?
Yes, unless you experience severe side effects like dizziness or joint pain. Adjust activity levels based on symptoms and consult your doctor.
Is it safe to stop Piroxicam?
To determine if it's safe to stop a medicine, first identify its purpose. If it's for managing a chronic condition like hypertension or diabetes, stopping it suddenly can lead to serious health risks, such as uncontrolled blood pressure or blood sugar levels. If the medicine is for symptomatic relief or treating a temporary condition, like an infection, stopping it might lead to a return of symptoms or incomplete treatment. Some medicines can cause withdrawal or rebound symptoms if stopped abruptly, which can be uncomfortable or dangerous. In some cases, stopping a medicine suddenly can lead to life-threatening complications. Therefore, it's crucial to consult with a doctor before stopping any medicine. They can provide guidance on how to safely discontinue the medicine, if appropriate, and suggest alternatives if needed.
Is Piroxicam addictive?
To determine if a medicine is addictive, we first need to know its name. If the medicine has habit-forming potential, it means it can cause dependence, which is when the body or mind feels a need for the drug. This can happen because the medicine changes how the brain works, making it hard to stop using it. Warning signs of addiction include needing more of the medicine to feel the same effects, using it even when it causes problems, or feeling bad when not using it. To avoid addiction, follow the doctor's instructions, don't take more than prescribed, and talk to a healthcare provider if you feel you need more of the medicine. If the medicine has no known potential for addiction, it means it doesn't cause these issues.
Is Piroxicam safe for the elderly?
Older people are more likely to have serious health problems, like heart, stomach, or kidney problems, when they take NSAIDs. These medicines are often used to relieve pain and inflammation. The benefits of taking these medicines should be considered carefully against the risks.
What are the most common side effects of Piroxicam?
A side effect is an unwanted or unexpected symptom caused by a medicine. For this medicine, common side effects may include nausea, which is feeling sick to your stomach, dizziness, which is feeling lightheaded or unsteady, headache, which is pain in the head, fatigue, which is feeling very tired, and dry mouth, which is a lack of saliva in the mouth. The frequency of these side effects can vary, but they are generally considered common. It's important to note that when starting a new medicine, people might experience new symptoms that could be coincidental, unrelated, or temporary. These symptoms might also be due to another health issue. Always talk to a healthcare provider before stopping any medicine, as they can provide guidance on managing side effects and ensure your treatment is safe and effective.
Who should avoid taking Piroxicam?
**Important Warnings:** * **Heart Risks:** NSAIDs can increase your risk of heart attack and stroke, especially if you take them for a long time or at high doses. * **Bleeding Risks:** NSAIDs can cause ulcers and bleeding in your stomach or intestines. This can be dangerous and can even lead to death. **Contraindications:** * Don't take NSAIDs before or after heart surgery (CABG). * Don't take NSAIDs for conditions they're not prescribed for. * Don't share NSAIDs with others, even if they have the same symptoms.