Pimozide
Psychotic Disorders, Huntington Disease ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Typical Antipsychotic
Controlled Drug Substance
NO
Pimozide
Learn more about this medicine -
Click HereSummary
Pimozide is primarily used for managing motor or verbal tics in patients with Tourette's disorder. It is also sometimes used for treating schizophrenia and other psychiatric disorders in adults.
Pimozide works by blocking dopamine receptors in the brain. This helps to reduce abnormal excitement and control symptoms like tics in Tourette's disorder.
Pimozide is taken orally, usually once a day at bedtime or in divided doses. The usual daily dose for adults ranges from 2 to 20 mg. For children over 12 years, the dose is similar to adults, but it should be carefully adjusted based on individual response and tolerance. Pimozide is not recommended for children under 12 years.
Common side effects of Pimozide include dizziness, sleepiness, muscle rigidity, and excessive sweating. Serious adverse effects may include heart problems, such as QT prolongation and ventricular arrhythmias, and a rare but serious condition called neuroleptic malignant syndrome.
Pimozide should not be taken by patients with long QT syndrome, cardiac arrhythmias, or electrolyte imbalances. It should also not be used with certain medications that prolong the QT interval. Regular heart monitoring is recommended due to the risk of serious heart problems. Pimozide is not approved for dementia-related behavior problems in older adults.
Indications and Purpose
How does one know if Pimozide is working?
The benefit of Pimozide is evaluated through regular doctor visits and laboratory tests to monitor the body's response. An electrocardiogram (ECG) is often used to check for heart-related side effects. Patients should report any unusual symptoms to their doctor.
How does Pimozide work?
Pimozide works by blocking dopamine receptors in the brain, which helps reduce abnormal excitement and control symptoms like tics in Tourette's disorder. It is part of the conventional antipsychotics class.
Is Pimozide effective?
Pimozide is effective in controlling motor or verbal tics in Tourette's disorder and is sometimes used for schizophrenia. It works by decreasing abnormal excitement in the brain. Its effectiveness is supported by clinical use, but individual response can vary.
What is Pimozide?
Pimozide is used to control motor or verbal tics in Tourette's disorder and sometimes for schizophrenia. It belongs to conventional antipsychotics and works by decreasing abnormal excitement in the brain. Pimozide is typically prescribed when other medications are ineffective.
What is Pimozide used for?
Pimozide is indicated for controlling motor or verbal tics in Tourette's disorder, especially when other treatments are ineffective. It is also sometimes used for schizophrenia and other psychiatric disorders in adults.
Directions for Use
For how long do I take Pimozide?
Pimozide is used for long-term management of conditions like Tourette's disorder and schizophrenia. The duration of use varies based on individual response and medical advice. It is important to follow your doctor's guidance and not stop the medication abruptly.
How do I take Pimozide?
Pimozide is taken orally, usually once a day at bedtime or in divided doses. It can be taken with or without food. Avoid grapefruit and grapefruit juice, as they can interfere with the medication's effectiveness.
How long does it take for Pimozide to start working?
Pimozide may take some time before you feel its full benefits. The exact time can vary, but it is important to continue taking it as prescribed and discuss any concerns with your doctor.
How should I store Pimozide?
Store Pimozide in its original container, tightly closed, at room temperature, away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Pimozide?
For adults, the usual daily dose of Pimozide ranges from 2 to 20 mg, starting at 2 mg and increasing as needed. For children over 12 years, the dose is similar to adults, but it should be carefully adjusted based on individual response and tolerance. Pimozide is not recommended for children under 12 years.
Warnings and Precautions
Can I take Pimozide with other prescription drugs?
Pimozide should not be taken with drugs that prolong the QT interval, such as certain antiarrhythmics, antidepressants, and antipsychotics. It should also be avoided with CYP3A4 and CYP2D6 inhibitors, as these can increase Pimozide levels and the risk of heart problems.
Can Pimozide be taken safely while breastfeeding?
Pimozide may be excreted in breast milk, so breastfeeding is not recommended while taking this medication. If Pimozide is essential, consider discontinuing breastfeeding. Consult your doctor for personalized advice.
Can Pimozide be taken safely while pregnant?
Pimozide should be used during pregnancy only if the benefits outweigh the risks. It may cause problems in newborns if taken in the last months of pregnancy. There is no strong evidence from human studies, but animal studies show potential risks. Consult your doctor for advice.
Is it safe to drink alcohol while taking Pimozide?
Drinking alcohol while taking Pimozide can worsen its side effects, such as drowsiness and dizziness. It is advised to avoid alcohol to ensure the medication's safety and effectiveness.
Is it safe to exercise while taking Pimozide?
Pimozide may cause dizziness, drowsiness, and muscle stiffness, which can affect your ability to exercise safely. It's important to understand how the medication affects you before engaging in physical activities. Consult your doctor for personalized advice.
Is Pimozide safe for the elderly?
Elderly patients should start with half the normal starting dose of Pimozide due to increased sensitivity to side effects. Pimozide is not approved for behavior problems in older adults with dementia, as it may increase the risk of death. Regular monitoring and dose adjustments are essential.
Who should avoid taking Pimozide?
Pimozide is contraindicated in patients with long QT syndrome, cardiac arrhythmias, or electrolyte imbalances. It should not be used with certain medications that prolong the QT interval. Pimozide may cause serious heart problems, so regular ECG monitoring is recommended. It is not approved for dementia-related behavior issues.
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