Phentermine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Sympathomimetic Amine Anorectic
Controlled Drug Substance
No
Phentermine
Summary
Phentermine is primarily used to aid in short-term weight loss in overweight individuals who are also following a low-calorie diet and exercise program. It is used for the management of obesity in patients with a body mass index (BMI) of 30 kg/m or greater, or 27 kg/m or greater in the presence of other risk factors such as hypertension, diabetes, or hyperlipidemia.
Phentermine is a sympathomimetic amine that acts as an anorectic. It works by stimulating the central nervous system, which increases heart rate and blood pressure and decreases appetite. It is similar in action to amphetamines and reduces hunger sensations.
Phentermine is typically taken as directed by your doctor, usually as a single daily dose in the morning or three times a day 30 minutes before meals. It can be taken with or without food. The dosage should be individualized to obtain an adequate response with the lowest effective dose.
Common side effects of Phentermine include dry mouth, unpleasant taste, diarrhea, constipation, and vomiting. Serious adverse effects can include increased blood pressure, heart palpitations, restlessness, dizziness, tremor, insomnia, shortness of breath, chest pain, and swelling of the legs and ankles.
Phentermine is contraindicated in individuals with a history of cardiovascular disease, hyperthyroidism, glaucoma, agitated states, and a history of drug abuse. It should not be used during pregnancy or nursing. It should not be combined with other weight loss drugs or alcohol. Caution is advised for those with hypertension.
Indications and Purpose
How does Phentermine work?
Phentermine acts as a sympathomimetic amine, similar to amphetamines, stimulating the central nervous system to decrease appetite and increase energy expenditure, aiding in weight loss.
Is Phentermine effective?
Clinical trials have shown that Phentermine, when combined with diet and exercise, can lead to more weight loss than diet and exercise alone. However, the weight loss is modest and varies among individuals.
What is Phentermine?
Phentermine is a medication used to aid weight loss in overweight individuals who are also following a low-calorie diet and exercise program. It belongs to a class of drugs called anorectics and works by decreasing appetite. Phentermine is typically prescribed for short-term use due to its potential for habit formation.
Directions for Use
For how long do I take Phentermine?
Phentermine is typically prescribed for short-term use, usually ranging from 3 to 6 weeks. The exact duration depends on individual response and should be determined by a healthcare provider.
How do I take Phentermine?
Phentermine should be taken as directed by your doctor, usually 30 minutes before meals. It can be taken with or without food, but follow your doctor's dietary and exercise recommendations for best results.
How long does it take for Phentermine to start working?
Phentermine typically starts working within a few hours of taking the dose, as it is designed to suppress appetite and aid in weight loss.
How should I store Phentermine?
Store Phentermine in its original container, tightly closed, at room temperature, away from excess heat and moisture. Keep it out of reach of children and dispose of it properly through a take-back program.
What is the usual dose of Phentermine?
The usual adult dose of Phentermine is one tablet three times a day, taken 30 minutes before meals. For children under 16 years of age, Phentermine is not recommended. Always follow your doctor's specific instructions regarding dosage.
Warnings and Precautions
Can I take Phentermine with other prescription drugs?
Phentermine should not be taken with MAO inhibitors due to the risk of hypertensive crisis. It may also interact with alcohol, insulin, and oral hypoglycemic medications, requiring dosage adjustments.
Can Phentermine be taken safely while breastfeeding?
Phentermine is not recommended while breastfeeding due to the potential for serious adverse reactions in nursing infants. Consult your doctor to discuss alternative weight loss options.
Can Phentermine be taken safely while pregnant?
Phentermine is contraindicated during pregnancy as weight loss offers no benefit and may harm the fetus. There is no strong evidence from human studies, but the potential risk is significant.
Is it safe to drink alcohol while taking Phentermine?
Drinking alcohol while taking Phentermine can worsen its side effects, such as dizziness and drowsiness. It is advised to avoid alcohol to ensure the safe and effective use of Phentermine.
Is it safe to exercise while taking Phentermine?
Phentermine may cause side effects like dizziness or shortness of breath, which can limit the ability to exercise. If you experience these symptoms, consult your doctor to adjust your treatment plan.
Is Phentermine safe for the elderly?
Older adults should use Phentermine with caution, as it may not be as safe as other medications for weight loss. Discuss the risks and benefits with your doctor before starting treatment.
Who should avoid taking Phentermine?
Phentermine is contraindicated in individuals with cardiovascular disease, hyperthyroidism, glaucoma, and a history of drug abuse. It should not be used with MAO inhibitors or during pregnancy and breastfeeding.
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