Phenoxymethylpenicillin
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Penicillin-class Antibacterial
Controlled Drug Substance
No
Phenoxymethylpenicillin
Summary
Phenoxymethylpenicillin is used to treat mild to moderately severe infections caused by penicillin-sensitive bacteria. These include streptococcal infections like pharyngitis and scarlet fever, pneumococcal infections of the respiratory tract, and Vincents gingivitis and pharyngitis. It's also used for the prevention of rheumatic fever.
Phenoxymethylpenicillin works by interfering with the synthesis of the bacterial cell wall, which is essential for bacterial growth and survival. This action leads to the death of the bacteria, effectively treating the infection.
For adults and children over 12 years, the usual dose is 250-500 mg every 6 hours. For children aged 6-12 years, the dose is 250 mg every 6 hours and for children aged 1-5 years, it is 125 mg every 6 hours. Always follow your doctor's instructions.
Common side effects of Phenoxymethylpenicillin include nausea, vomiting, diarrhea, and black hairy tongue. Serious adverse effects can include allergic reactions like rash, hives, and anaphylaxis.
Phenoxymethylpenicillin should not be used by individuals with a known allergy to penicillin. It should be used cautiously in those with a history of allergies or asthma. Severe infections should not be treated with this medication. If an allergic reaction occurs, discontinue use and seek medical attention immediately.
Indications and Purpose
How does Phenoxymethylpenicillin work?
Phenoxymethylpenicillin works by inhibiting the synthesis of the bacterial cell wall, which is essential for bacterial growth and survival. This action leads to the death of the bacteria, effectively treating the infection. It is particularly effective against gram-positive bacteria and some gram-negative cocci.
Is Phenoxymethylpenicillin effective?
Phenoxymethylpenicillin is effective against many gram-positive bacteria and some gram-negative cocci. It works by interfering with the synthesis of the bacterial cell wall, which is essential for bacterial growth and survival. Its effectiveness is supported by its ability to treat infections like pharyngitis, scarlet fever, and mild respiratory infections.
What is Phenoxymethylpenicillin?
Phenoxymethylpenicillin is an antibiotic used to treat mild to moderately severe infections caused by penicillin-sensitive bacteria, such as pharyngitis, scarlet fever, and respiratory tract infections. It works by interfering with the synthesis of the bacterial cell wall, leading to the death of the bacteria. This medication is effective against many gram-positive bacteria and some gram-negative cocci.
Directions for Use
For how long do I take Phenoxymethylpenicillin?
The typical duration of use for Phenoxymethylpenicillin is usually 10 days for streptococcal infections to ensure the bacteria are fully eradicated. For otitis media, treatment is typically limited to 5 days, but may extend to 10 days if complications are possible. Always follow your doctor's guidance.
How do I take Phenoxymethylpenicillin?
Phenoxymethylpenicillin should be taken on an empty stomach, either half an hour before or at least two hours after a meal, to ensure better absorption. There are no specific food restrictions, but it's important to follow your doctor's instructions regarding dosage and timing.
How long does it take for Phenoxymethylpenicillin to start working?
Phenoxymethylpenicillin typically starts working within a few hours of taking the first dose. However, it may take a few days to notice a significant improvement in symptoms. It's important to complete the full course of treatment as prescribed by your doctor.
How should I store Phenoxymethylpenicillin?
Store Phenoxymethylpenicillin in a cool, dry place away from heat, light, and moisture. Keep it out of reach of children. If in liquid form, it should be refrigerated and any unused portion should be discarded after 14 days. Do not freeze the medication.
What is the usual dose of Phenoxymethylpenicillin?
For adults, the usual dose is 250-500 mg every 6 hours, depending on the severity of the condition. For children over 12 years, the dose is the same as adults. For children aged 6-12 years, the dose is 250 mg every 6 hours, and for children aged 1-5 years, it is 125 mg every 6 hours. Always follow your doctor's instructions.
Warnings and Precautions
Can I take Phenoxymethylpenicillin with other prescription drugs?
Phenoxymethylpenicillin may interact with uricosuric drugs like probenecid, which can reduce its excretion and increase plasma levels. It should not be combined with bacteriostatic antibiotics like tetracycline, as they can interfere with its effectiveness. Always inform your doctor about all medications you are taking.
Can Phenoxymethylpenicillin be taken safely while breastfeeding?
Phenoxymethylpenicillin is excreted in breast milk and should be used with caution in nursing mothers. It may cause an allergic reaction in the infant. Consult a healthcare provider to weigh the benefits and risks before using this medication while breastfeeding.
Can Phenoxymethylpenicillin be taken safely while pregnant?
Phenoxymethylpenicillin is generally considered safe during pregnancy, with no evidence of teratogenicity in human studies. However, as with any medication, it should be used under the guidance of a healthcare provider to ensure safety for both the mother and the fetus.
Is Phenoxymethylpenicillin safe for the elderly?
Elderly patients should use Phenoxymethylpenicillin with caution, especially if they have impaired renal function, as the dosage may need to be reduced. It's important to monitor kidney function and adjust the dose accordingly. Always consult a healthcare provider for personalized advice.
Who should avoid taking Phenoxymethylpenicillin?
Phenoxymethylpenicillin should not be used by individuals with a known allergy to penicillin or any of its components. It should be used cautiously in those with a history of allergies or asthma. Severe infections should not be treated with this medication. If an allergic reaction occurs, discontinue use and seek medical attention immediately.
