Phenoxybenzamine
Malignant Hypertension, Pheochromocytoma ... show more
.svg)
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Alpha-Adrenergic Blocker
Controlled Drug Substance
No
Phenoxybenzamine
Summary
Phenoxybenzamine is used to treat high blood pressure and excessive sweating associated with a condition called pheochromocytoma. It's also used to manage bladder control problems such as frequent urination, urgency, and inability to control urination.
Phenoxybenzamine is an adrenergic receptor-blocking agent. It works by blocking alpha receptors, which leads to increased blood flow to the skin and lower blood pressure. This helps manage symptoms of pheochromocytoma and bladder issues.
Phenoxybenzamine is taken orally, usually two or three times a day. The initial dose for adults is typically 10 mg twice a day, which may be increased to 20 to 40 mg two or three times a day depending on your response and tolerance.
Common side effects of Phenoxybenzamine include nasal congestion, dizziness, upset stomach, and sexual dysfunction. Serious side effects may include fainting, rapid heartbeat, and vomiting. If you experience these, contact your doctor immediately.
Phenoxybenzamine should not be used if a drop in blood pressure is undesirable. It's not recommended for long-term use due to potential carcinogenic risks. Caution is advised for patients with heart, kidney, or cerebrovascular conditions. It's also contraindicated for those with hypersensitivity to the drug.
Indications and Purpose
How does Phenoxybenzamine work?
Phenoxybenzamine works by blocking alpha receptors in the body, which relaxes blood vessels and lowers blood pressure. Think of it like opening a valve to reduce pressure in a pipe. This action helps improve blood flow and reduces symptoms like high blood pressure. It's effective for conditions like pheochromocytoma, which is a tumor that can cause high blood pressure.
Is Phenoxybenzamine effective?
Phenoxybenzamine is effective for treating high blood pressure and certain conditions like pheochromocytoma, which is a tumor that can cause high blood pressure. It works by blocking certain receptors, relaxing blood vessels, and lowering blood pressure. Clinical studies support its effectiveness in managing these conditions. Always follow your doctor's instructions to achieve the best results.
What is Phenoxybenzamine?
Phenoxybenzamine is a medication that belongs to the class of alpha-blockers. It works by relaxing blood vessels, which helps lower blood pressure. It's primarily used to treat high blood pressure and conditions like pheochromocytoma, which is a tumor that can cause high blood pressure. Phenoxybenzamine is often used in combination with other therapies to manage these conditions effectively.
Directions for Use
For how long do I take Phenoxybenzamine?
Phenoxybenzamine is usually a long-term medication for managing conditions like high blood pressure or pheochromocytoma. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. Always talk with your doctor before changing or stopping your Phenoxybenzamine treatment.
How do I dispose of Phenoxybenzamine?
Dispose of unused Phenoxybenzamine by taking it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Phenoxybenzamine?
Take Phenoxybenzamine as prescribed by your doctor. It's usually taken twice daily, in the morning and evening. You can take it with or without food. If you have trouble swallowing pills, ask your doctor if it can be crushed. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose. Don't take two doses at once. Avoid alcohol, as it can increase side effects. Always follow your doctor's specific instructions.
How long does it take for Phenoxybenzamine to start working?
Phenoxybenzamine starts working within a few hours after taking it, but it may take several days to achieve its full effect. The time it takes to work can vary based on individual factors like your condition and overall health. Regular monitoring by your doctor will help assess how well the medication is working for you.
How should I store Phenoxybenzamine?
Store Phenoxybenzamine at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Phenoxybenzamine?
The usual starting dose of Phenoxybenzamine for adults is 10 mg twice daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 40 mg per day. For elderly patients, dose adjustments may be necessary due to increased sensitivity. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can I take Phenoxybenzamine with other prescription drugs?
Phenoxybenzamine can interact with other medications, increasing the risk of side effects. For example, it can enhance the effects of blood pressure-lowering drugs, leading to very low blood pressure. Always inform your doctor about all medications you're taking to avoid potential interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Can Phenoxybenzamine be taken safely while breastfeeding?
Phenoxybenzamine is not recommended while breastfeeding. There's limited information on whether it passes into breast milk or its effects on the breastfed infant. If you're taking Phenoxybenzamine and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Phenoxybenzamine be taken safely while pregnant?
Phenoxybenzamine is not recommended during pregnancy unless absolutely necessary. There's limited evidence on its safety, and it may affect the developing baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition. Your doctor can help create a plan that protects both you and your baby.
Does Phenoxybenzamine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Phenoxybenzamine include nasal congestion, fatigue, and dizziness. These occur occasionally and are usually mild. Serious side effects, like very low blood pressure, are rare but require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these are related to Phenoxybenzamine and suggest appropriate actions.
Does Phenoxybenzamine have any safety warnings?
Yes, Phenoxybenzamine has important safety warnings. It can cause low blood pressure, which may lead to dizziness or fainting, especially when standing up quickly. This is because it relaxes blood vessels, lowering blood pressure. Not following these warnings can result in falls or injuries. Always rise slowly from sitting or lying positions. If you experience severe dizziness or fainting, seek medical help immediately. Regular monitoring by your doctor is important to manage these risks.
Is it safe to drink alcohol while taking Phenoxybenzamine?
It's best to avoid alcohol while taking Phenoxybenzamine. Alcohol can increase the risk of side effects like dizziness or low blood pressure. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or fainting. Talk with your doctor about alcohol use while taking Phenoxybenzamine for personalized advice.
Is it safe to exercise while taking Phenoxybenzamine?
You can exercise while taking Phenoxybenzamine, but be cautious. This medication can cause dizziness or low blood pressure, especially when standing up quickly. To exercise safely, drink plenty of water and avoid strenuous activities if you feel dizzy. If you notice symptoms like dizziness or unusual fatigue, slow down or stop exercising and rest. Consult your doctor if you have concerns.
Is it safe to stop Phenoxybenzamine?
Stopping Phenoxybenzamine suddenly can cause your symptoms to return or worsen. It's usually used for long-term management of conditions like high blood pressure. If you need to stop, your doctor might suggest gradually reducing your dose to avoid complications. Always talk with your doctor before stopping Phenoxybenzamine to ensure it's done safely.
Is Phenoxybenzamine addictive?
Phenoxybenzamine is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by blocking certain receptors in the body, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings or feel compelled to take more than prescribed. If you have concerns about medication dependence, Phenoxybenzamine doesn't carry this risk.
Is Phenoxybenzamine safe for the elderly?
Elderly individuals are more vulnerable to the side effects of Phenoxybenzamine, such as low blood pressure and dizziness. These effects can increase the risk of falls. It's important for elderly patients to be closely monitored by their doctor while taking this medication. Dose adjustments may be necessary to ensure safety and effectiveness.
What are the most common side effects of Phenoxybenzamine?
Side effects are unwanted reactions to a medication. Common side effects of Phenoxybenzamine include nasal congestion, fatigue, and dizziness. These occur occasionally and are usually mild. If you experience new symptoms after starting Phenoxybenzamine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Phenoxybenzamine?
Phenoxybenzamine should not be used if you have a known allergy to it or its ingredients. This is an absolute contraindication. Relative contraindications include conditions like severe heart disease, where caution is needed. The drug may be used only if the benefits outweigh the risks. Always consult your doctor about your medical history before starting Phenoxybenzamine.
Forms / Brands
