Pertuzumab
Extravasation of Diagnostic and Therapeutic Materials , Breast Neoplasms ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
HER2/neu Receptor Antagonist
Controlled Drug Substance
NO
Summary
Pertuzumab is used to treat HER2-positive breast cancer, which is a type of cancer that has high levels of a protein called HER2 that promotes cancer cell growth.
Pertuzumab works by blocking the HER2 protein, which is a protein that promotes cancer cell growth, helping to slow or stop the progression of the disease.
Pertuzumab is given as an intravenous infusion, which means it's administered directly into your vein. The starting dose is 840 mg, followed by 420 mg every three weeks.
Common side effects of pertuzumab include diarrhea, hair loss, and fatigue, which is a feeling of extreme tiredness.
Pertuzumab can cause heart problems, including heart failure, which is when the heart can't pump blood effectively. It's not recommended during pregnancy due to potential harm to the unborn baby.
Indications and Purpose
How does pertuzumab work?
Pertuzumab is a monoclonal antibody that targets the HER2 protein on cancer cells. It works by blocking signals that promote cancer cell growth. Think of it like a key that fits into a lock, preventing the lock from opening. This action helps slow or stop the growth of HER2-positive breast cancer.
Is pertuzumab effective?
Pertuzumab is effective in treating certain types of breast cancer. It works by targeting a protein called HER2, which promotes cancer cell growth. Clinical studies show that pertuzumab, when used with other cancer treatments, can improve survival rates and slow disease progression in patients with HER2-positive breast cancer.
What is pertuzumab?
Pertuzumab is a medication used to treat HER2-positive breast cancer. It belongs to a class of drugs called monoclonal antibodies, which target specific proteins on cancer cells. Pertuzumab works by blocking the HER2 protein, which promotes cancer cell growth. It's often used in combination with other cancer treatments to improve outcomes.
Directions for Use
For how long do I take pertuzumab?
Pertuzumab is usually part of a long-term treatment plan for HER2-positive breast cancer. The duration of treatment depends on your response and any side effects. Your doctor will guide you on how long to continue treatment. Always talk with your doctor before changing or stopping your pertuzumab treatment.
How do I dispose of pertuzumab?
Dispose of unused pertuzumab by returning it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, follow local guidelines for medication disposal. Never throw it in the trash or flush it down the toilet to prevent harm to others and the environment.
How do I take pertuzumab?
Pertuzumab is given as an intravenous infusion, which means it's administered directly into your vein. The first dose usually takes about 60 minutes, and subsequent doses take about 30 to 60 minutes. It's typically given every three weeks. You don't need to take it with food, and it can't be crushed or taken orally. If you miss a dose, contact your healthcare provider for instructions.
How long does it take for pertuzumab to start working?
Pertuzumab starts working in your body shortly after administration, but noticeable effects may take weeks. The full therapeutic effect can vary depending on individual factors like cancer type and stage. Regular monitoring through tests and check-ups will help assess how well the medication is working for you.
How should I store pertuzumab?
Store pertuzumab in a refrigerator at 2°C to 8°C (36°F to 46°F). Keep it in its original packaging to protect it from light. Do not freeze or shake the medication. If you have any questions about storage, ask your healthcare provider for guidance.
What is the usual dose of pertuzumab?
The usual starting dose of pertuzumab for adults is 840 mg, followed by 420 mg every three weeks. The dose is given as an intravenous infusion. Your doctor may adjust the dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take pertuzumab with other prescription drugs?
Pertuzumab can interact with other cancer treatments, increasing the risk of side effects. It's important to inform your doctor about all medications you're taking, including over-the-counter drugs and supplements. Your doctor will monitor for interactions and adjust your treatment as needed to ensure safety and effectiveness.
Can pertuzumab be taken safely while breastfeeding?
Pertuzumab is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, due to potential risks to the baby, it's best to avoid breastfeeding while on this medication. Talk with your doctor about safer options if you wish to breastfeed.
Can pertuzumab be taken safely while pregnant?
Pertuzumab is not recommended during pregnancy due to potential risks to the unborn baby. It can harm fetal development, especially in the later stages of pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a plan that protects both you and your baby.
Does pertuzumab have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of pertuzumab include diarrhea, hair loss, and fatigue. Serious side effects can include heart problems and allergic reactions. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to pertuzumab and suggest appropriate actions.
Does pertuzumab have any safety warnings?
Yes, pertuzumab has important safety warnings. It can cause heart problems, including heart failure, which is when your heart can't pump blood effectively. Your doctor will monitor your heart function during treatment. If you experience symptoms like shortness of breath or swelling in your legs, contact your doctor immediately. Adhering to these warnings is crucial to avoid serious health issues.
Is it safe to drink alcohol while taking pertuzumab?
It's best to avoid alcohol while taking pertuzumab. Alcohol can increase the risk of side effects like dehydration and liver problems. If you choose to drink, limit your intake and watch for any unusual symptoms. Talk with your doctor about alcohol use while on pertuzumab to get personalized advice.
Is it safe to exercise while taking pertuzumab?
You can exercise while taking pertuzumab, but listen to your body. This medication can cause fatigue, which might limit your exercise capacity. If you feel dizzy or unusually tired, slow down or stop exercising and rest. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns.
Is it safe to stop pertuzumab?
Stopping pertuzumab without medical advice can affect your cancer treatment. It's usually part of a long-term treatment plan for cancer. Stopping suddenly might allow the cancer to progress. Always talk with your doctor before stopping pertuzumab. They can guide you on how to safely adjust your treatment if needed.
Is pertuzumab addictive?
Pertuzumab is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is pertuzumab safe for the elderly?
The elderly may be more vulnerable to side effects from pertuzumab, such as heart problems or fatigue. It's important for older adults to have regular check-ups to monitor their response to the medication. Your doctor will consider your overall health and any other medications you take to ensure pertuzumab is safe for you.
What are the most common side effects of pertuzumab?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of pertuzumab include diarrhea, hair loss, and fatigue. These effects vary from person to person. If you notice new symptoms after starting pertuzumab, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking pertuzumab?
Don't use pertuzumab if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Pertuzumab is not recommended during pregnancy due to potential harm to the unborn baby. Always consult your doctor about any concerns or conditions that might affect your treatment with pertuzumab.
