Perphenazine
Nausea, Schizophrenia ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Phenothiazine
Controlled Drug Substance
No
Perphenazine
Summary
Perphenazine is used for treating symptoms of schizophrenia and controlling severe nausea and vomiting in adults.
Perphenazine works by decreasing abnormal excitement in the brain. This helps manage symptoms of schizophrenia and control severe nausea and vomiting.
For adults with schizophrenia, the usual dose is 4 to 8 mg taken three times a day. For severe nausea and vomiting, 8 to 16 mg daily in divided doses is typical.
Common side effects include drowsiness, dizziness, dry mouth, restlessness, unusual dreams, and changes in weight. Serious effects like fever, muscle stiffness, and irregular heartbeat require immediate medical attention.
Perphenazine is not recommended for children under 12 years of age or for dementia-related psychosis due to increased mortality risk. It can cause tardive dyskinesia, neuroleptic malignant syndrome, and lower seizure thresholds. Avoid use in patients with severe liver damage or hypersensitivity.
Indications and Purpose
How does Perphenazine work?
Perphenazine works by decreasing abnormal excitement in the brain, helping to manage symptoms of schizophrenia and control severe nausea and vomiting. It belongs to a class of drugs called conventional antipsychotics.
Is Perphenazine effective?
Perphenazine is effective in treating schizophrenia symptoms and controlling severe nausea and vomiting. It works by reducing abnormal brain excitement, though individual responses can vary. Always follow your doctor's guidance.
What is Perphenazine?
Perphenazine is used to treat schizophrenia symptoms and control severe nausea and vomiting. It belongs to conventional antipsychotics, working by reducing abnormal excitement in the brain to help manage symptoms.
Directions for Use
For how long do I take Perphenazine?
Perphenazine is used to manage symptoms and is often taken long-term for chronic conditions like schizophrenia. The duration depends on individual response and medical advice. Always follow your doctor's guidance on how long to take it.
How do I take Perphenazine?
Take Perphenazine as directed by your doctor, usually two to four times daily. It can be taken with or without food, and there are no specific food restrictions unless advised by your doctor.
How long does it take for Perphenazine to start working?
Perphenazine may start to show effects within a few days, but it can take several weeks to experience the full benefits. Always follow your doctor's instructions and report any concerns.
How should I store Perphenazine?
Store Perphenazine in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children to prevent accidental ingestion.
What is the usual dose of Perphenazine?
For adults with schizophrenia, the usual dose is 4 to 8 mg taken three times a day, with a maximum of 64 mg per day for hospitalized patients. For severe nausea and vomiting, 8 to 16 mg daily in divided doses is typical. Perphenazine is not recommended for children under 12 years of age.
Warnings and Precautions
Can I take Perphenazine with other prescription drugs?
Perphenazine can interact with drugs that affect the central nervous system, such as antidepressants and antihistamines, increasing side effects. Inform your doctor of all medications you're taking to avoid harmful interactions.
Can Perphenazine be taken safely while pregnant?
Perphenazine should be used during pregnancy only if the benefits outweigh the risks. It may cause problems in newborns if taken in the last months of pregnancy. Consult your doctor for personalized advice.
Is it safe to drink alcohol while taking Perphenazine?
Drinking alcohol while taking Perphenazine can worsen its side effects, such as drowsiness and dizziness. It is advised to avoid alcohol to prevent increased risk of side effects and potential harm.
Is it safe to exercise while taking Perphenazine?
Perphenazine may cause dizziness and drowsiness, which can affect your ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities and consult your doctor for guidance.
Is Perphenazine safe for the elderly?
Elderly patients are more sensitive to Perphenazine's side effects, such as dizziness and drowsiness, which can increase fall risk. Lower starting doses are recommended, and close monitoring is essential to ensure safety.
Who should avoid taking Perphenazine?
Perphenazine is not approved for dementia-related psychosis due to increased mortality risk. It can cause tardive dyskinesia, neuroleptic malignant syndrome, and lower seizure thresholds. Avoid use in patients with severe liver damage or hypersensitivity.
