Perampanel

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Brand Name

Fycompa 2mg Tablet 14s , Fycompa 2mg Tablet 7s ... show more

Approved Treatment Indication:

Partial Epilepsies, Tonic-Clonic Epilepsy ... show more

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What conditions Perampanel is used for
Perampanel is used to treat seizures associated with epilepsy, which is a disorder where nerve cell activity in the brain is disturbed, causing seizures. It is often added to other seizure medications to help control these episodes.
How Perampanel works in the body
Perampanel works by blocking AMPA receptors, which are involved in transmitting electrical signals in the brain. This action helps reduce abnormal electrical activity that leads to seizures, similar to turning down the volume on a loudspeaker to reduce noise.
The usual dosages and routes of administration of Perampanel
The usual starting dose of Perampanel for adults is 2 mg once daily at bedtime. The dose may be gradually increased by your doctor based on your response and tolerance, with a maximum recommended dose of 12 mg per day. It is taken orally, with or without food.
The most commonly observed adverse effects of Perampanel
Common side effects of Perampanel include dizziness, drowsiness, and fatigue, which refer to feeling tired or lacking energy. These effects are usually temporary and may improve as your body adjusts to the medication.
Important safety warnings and contraindications of Perampanel
Perampanel can cause serious psychiatric and behavioral reactions, including aggression and mood changes. It may also cause dizziness and drowsiness, increasing the risk of falls. Avoid alcohol, as it can worsen these effects. It is not recommended for people with severe liver impairment or those allergic to its ingredients.

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Noncompetitive AMPA Glutamate Receptor Antagonist

Controlled Drug Substance

YES

Summary

What conditions Perampanel is used for
Perampanel is used to treat seizures associated with epilepsy, which is a disorder where nerve cell activity in the brain is disturbed, causing seizures. It is often added to other seizure medications to help control these episodes.
How Perampanel works in the body
Perampanel works by blocking AMPA receptors, which are involved in transmitting electrical signals in the brain. This action helps reduce abnormal electrical activity that leads to seizures, similar to turning down the volume on a loudspeaker to reduce noise.
The usual dosages and routes of administration of Perampanel
The usual starting dose of Perampanel for adults is 2 mg once daily at bedtime. The dose may be gradually increased by your doctor based on your response and tolerance, with a maximum recommended dose of 12 mg per day. It is taken orally, with or without food.
The most commonly observed adverse effects of Perampanel
Common side effects of Perampanel include dizziness, drowsiness, and fatigue, which refer to feeling tired or lacking energy. These effects are usually temporary and may improve as your body adjusts to the medication.
Important safety warnings and contraindications of Perampanel
Perampanel can cause serious psychiatric and behavioral reactions, including aggression and mood changes. It may also cause dizziness and drowsiness, increasing the risk of falls. Avoid alcohol, as it can worsen these effects. It is not recommended for people with severe liver impairment or those allergic to its ingredients.

Indications and Purpose

How does Perampanel work?

Perampanel works by blocking AMPA receptors in the brain, which are involved in transmitting electrical signals. By reducing the activity of these receptors, Perampanel helps decrease abnormal electrical activity that leads to seizures. Think of it like turning down the volume on a loudspeaker to reduce noise. This action helps control seizures in people with epilepsy. Always take Perampanel as prescribed to achieve the best results.

Is Perampanel effective?

Perampanel is effective in treating seizures associated with epilepsy. It works by reducing abnormal electrical activity in the brain. Clinical studies show that Perampanel can significantly decrease the frequency of seizures in patients with epilepsy. It is important to take Perampanel as prescribed and attend regular check-ups with your doctor to monitor its effectiveness and adjust the treatment if necessary.

What is Perampanel?

Perampanel is a medication used to treat seizures associated with epilepsy. It belongs to a class of drugs called AMPA receptor antagonists, which work by reducing abnormal electrical activity in the brain. Perampanel is used as an adjunctive therapy, meaning it is added to other seizure medications to help control seizures. It is important to follow your doctor's instructions and take Perampanel as prescribed to manage your condition effectively.

Directions for Use

For how long do I take Perampanel?

Perampanel is usually taken long-term for managing epilepsy, which is a chronic condition. The duration of use depends on your response to the medication and your doctor's recommendations. It's important to take Perampanel as prescribed and not stop it suddenly without consulting your doctor. Your doctor will guide you on how long to continue the medication based on your individual health needs.

How do I dispose of Perampanel?

Dispose of unused Perampanel by taking it to a drug take-back program or collection site at a pharmacy or hospital. If these options are not available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent accidental ingestion or harm to the environment.

How do I take Perampanel?

Take Perampanel once daily, usually at bedtime. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Avoid alcohol while taking Perampanel, as it can increase side effects like dizziness. Always follow your doctor's instructions regarding dosage and any dietary restrictions.

How long does it take for Perampanel to start working?

Perampanel starts working shortly after you take it, but it may take several weeks to see the full therapeutic effect. The time it takes to work can vary based on individual factors like your condition and response to the medication. It's important to take Perampanel as prescribed and attend regular check-ups with your doctor to monitor its effectiveness. If you have concerns about how long it takes to work, discuss them with your healthcare provider.

How should I store Perampanel?

Store Perampanel at room temperature, away from moisture and light. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom, as humidity can affect the medication. Check the expiration date regularly and dispose of any unused or expired medication properly. Always follow storage instructions to maintain the medication's effectiveness.

What is the usual dose of Perampanel?

The usual starting dose of Perampanel for adults is 2 mg once daily at bedtime. Your doctor may gradually increase your dose based on your response and tolerance. The maximum recommended dose is 12 mg per day. Dose adjustments may be necessary for elderly patients or those with liver problems. Always follow your doctor's specific dosing instructions for your health needs.

Warnings and Precautions

Can I take Perampanel with other prescription drugs?

Perampanel can interact with other medications, increasing the risk of side effects or reducing effectiveness. It may interact with other central nervous system depressants, like benzodiazepines, increasing drowsiness. Enzyme inducers like carbamazepine can reduce Perampanel's effectiveness. Always inform your doctor about all medications you are taking to avoid interactions. They can adjust your treatment plan to ensure safety and effectiveness.

Can Perampanel be taken safely while breastfeeding?

Perampanel is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk. Animal studies suggest it may be present in milk, raising concerns about potential effects on the baby. If you are breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. They can help you choose a treatment that allows you to nurse safely.

Can Perampanel be taken safely while pregnant?

Perampanel is not recommended during pregnancy unless absolutely necessary. There is limited information on its safety in pregnant women, and it may pose risks to the unborn baby. If you are pregnant or planning to become pregnant, discuss with your doctor the potential risks and benefits of using Perampanel. Your doctor can help determine the safest treatment plan for you and your baby.

Does Perampanel have adverse effects?

Adverse effects are unwanted reactions to a medication. Common adverse effects of Perampanel include dizziness, drowsiness, and fatigue. Serious side effects can include mood changes, aggression, and suicidal thoughts. If you experience any severe or concerning symptoms, contact your doctor immediately. It's important to report any new or worsening symptoms to your healthcare provider to ensure your treatment is safe and effective.

Does Perampanel have any safety warnings?

Yes, Perampanel has important safety warnings. It can cause serious psychiatric and behavioral reactions, including aggression, hostility, and anger. These effects can occur at any time during treatment. Perampanel may also cause dizziness and drowsiness, increasing the risk of falls. It's important to avoid alcohol, as it can worsen these side effects. If you experience any unusual changes in mood or behavior, contact your doctor immediately. Always adhere to safety warnings to prevent serious consequences.

Is it safe to drink alcohol while taking Perampanel?

It's best to avoid alcohol while taking Perampanel. Alcohol can increase the risk of side effects like dizziness, drowsiness, and mood changes. It may also worsen the medication's effects on the central nervous system. If you choose to drink occasionally, limit your alcohol intake and be aware of any warning signs like increased drowsiness or mood changes. Discuss alcohol use with your doctor for personalized advice.

Is it safe to exercise while taking Perampanel?

You can exercise while taking Perampanel, but be cautious. This medication can cause dizziness and drowsiness, which might affect your balance and coordination during physical activity. Start with light exercises and gradually increase intensity as you see how your body responds. Stay hydrated and avoid strenuous activities if you feel dizzy or lightheaded. Consult your doctor if you have concerns about exercising while on Perampanel.

Is it safe to stop Perampanel?

It's not safe to stop Perampanel suddenly without consulting your doctor. Stopping abruptly can lead to withdrawal symptoms or worsening of your condition. If you need to stop taking Perampanel, your doctor will guide you on how to gradually reduce the dose to minimize risks. Always follow your doctor's instructions when making changes to your medication regimen.

Is Perampanel addictive?

Perampanel is not considered addictive or habit-forming. It does not cause physical or psychological dependence. However, it is important to take it exactly as prescribed by your doctor. Do not take more than the recommended dose, and do not stop taking it suddenly without consulting your healthcare provider. If you have concerns about medication dependence, discuss them with your doctor.

Is Perampanel safe for the elderly?

Elderly individuals may be more sensitive to the side effects of Perampanel, such as dizziness and drowsiness, which can increase the risk of falls. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Dose adjustments may be necessary based on their response and tolerance. Always discuss any concerns with your doctor to ensure safe use of Perampanel in elderly patients.

What are the most common side effects of Perampanel?

Side effects are unwanted reactions to a medication. Common side effects of Perampanel include dizziness, drowsiness, and fatigue. These occur in more than 10% of people taking the medication. If you experience these side effects, they may be temporary and improve as your body adjusts. However, if they persist or worsen, talk with your doctor. Always report new symptoms to your healthcare provider.

Who should avoid taking Perampanel?

Perampanel should not be used if you are allergic to it or any of its ingredients. It is also contraindicated in people with severe liver impairment. Caution is needed in patients with a history of psychiatric disorders, as Perampanel can cause mood changes and aggression. Always inform your doctor about your medical history and any other medications you are taking to ensure Perampanel is safe for you.