Pazopanib
Renal Cell Carcinoma, Soft Tissue Neoplasms
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
NO
Pazopanib
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Click HereSummary
Pazopanib is used to treat advanced renal cell carcinoma and certain types of soft tissue sarcoma. These are types of cancer that have spread or cannot be surgically removed.
Pazopanib is a kinase inhibitor. It works by blocking certain proteins that are involved in the growth and spread of cancer cells. By doing this, it helps to slow down or stop the progression of cancer.
The usual daily dose of Pazopanib for adults is 800 mg, taken orally once a day on an empty stomach. It should be taken at least 1 hour before or 2 hours after a meal. The tablets should be swallowed whole without crushing or chewing.
Common side effects of Pazopanib include diarrhea, high blood pressure, changes in hair color, nausea, and fatigue. More serious side effects can include liver damage, heart problems, and bleeding issues.
Pazopanib can cause severe liver damage, so regular liver function tests are important. It can also cause high blood pressure, heart problems, and bleeding issues. It's not recommended for use during pregnancy or breastfeeding, or in children. Patients with a history of liver disease, heart conditions, or recent surgery should use caution.
Indications and Purpose
How does one know if Pazopanib is working?
The benefit of Pazopanib is evaluated through regular medical check-ups and laboratory tests, including liver function tests and blood pressure monitoring. These assessments help determine how well the medication is working and whether any adjustments to the treatment plan are needed.
How does Pazopanib work?
Pazopanib is a kinase inhibitor that works by blocking certain proteins involved in cancer cell growth and spread. By inhibiting these proteins, Pazopanib helps slow or stop the progression of cancer, making it an effective treatment for certain types of advanced cancer.
Is Pazopanib effective?
Pazopanib has been shown to be effective in treating advanced renal cell carcinoma and certain types of soft tissue sarcoma. Clinical trials have demonstrated its ability to slow disease progression and, in some cases, reduce tumor size. The effectiveness of Pazopanib is supported by its ability to inhibit cancer cell growth and spread.
What is Pazopanib?
Pazopanib is used to treat advanced renal cell carcinoma and certain types of soft tissue sarcoma. It works by inhibiting specific proteins that promote cancer cell growth and spread, effectively slowing or stopping the progression of the disease. Regular monitoring is essential to manage potential side effects and ensure the medication's effectiveness.
What is Pazopanib used for?
Pazopanib is indicated for the treatment of advanced renal cell carcinoma and certain types of advanced soft tissue sarcoma in adults. It is used when the cancer has spread or cannot be surgically removed, helping to slow the progression of the disease.
Directions for Use
For how long do I take Pazopanib?
Pazopanib is typically used until disease progression or unacceptable toxicity occurs. The duration of use can vary based on individual response and tolerance to the medication. Always follow your doctor's guidance regarding the length of treatment.
How do I take Pazopanib?
Pazopanib should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow the tablets whole without crushing or chewing. Avoid eating grapefruit or drinking grapefruit juice while taking this medication, as it can increase the risk of side effects.
How should I store Pazopanib?
Store Pazopanib in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. For disposal, use a medicine take-back program if available, and avoid flushing it down the toilet.
What is the usual dose of Pazopanib?
For adults, the usual daily dose of Pazopanib is 800 mg taken orally once a day on an empty stomach. For children, the safety and effectiveness of Pazopanib have not been established, and it is not recommended for use in pediatric patients. Always follow your doctor's advice for dosing.
Warnings and Precautions
Can I take Pazopanib with other prescription drugs?
Pazopanib can interact with several medications, including strong CYP3A4 inhibitors and inducers, which can affect its concentration in the body. It also interacts with simvastatin, increasing the risk of liver damage. Patients should inform their doctor of all medications they are taking to avoid potential interactions.
Can Pazopanib be taken safely while breastfeeding?
Women are advised not to breastfeed during treatment with Pazopanib and for 2 weeks after the final dose due to the potential for serious adverse reactions in breastfed infants. It's important to discuss any concerns with your doctor to ensure the safety of your child.
Can Pazopanib be taken safely while pregnant?
Pazopanib can cause fetal harm and is not recommended for use during pregnancy. Women of reproductive potential should use effective contraception during treatment and for at least 2 weeks after the last dose. If pregnancy occurs, patients should inform their doctor immediately due to the potential risk to the fetus.
Is it safe to exercise while taking Pazopanib?
Pazopanib may cause fatigue, which could limit your ability to exercise. If you experience significant fatigue or any other symptoms that affect your ability to exercise, discuss them with your doctor. They can provide guidance on managing these symptoms and adjusting your activity level.
Is Pazopanib safe for the elderly?
In clinical trials, no overall differences in safety or effectiveness of Pazopanib were observed between elderly patients and younger patients. However, elderly patients may be at greater risk for certain side effects, such as liver toxicity. It's important for elderly patients to have regular monitoring and to discuss any concerns with their doctor.
Who should avoid taking Pazopanib?
Pazopanib can cause severe liver damage, so regular liver function tests are important. It may also cause high blood pressure, heart problems, and bleeding issues. Patients with a history of liver disease, heart conditions, or recent surgery should use caution. Pregnant or breastfeeding women should avoid using Pazopanib due to potential harm to the baby.
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