Paromomycin
Amebiasis, Cryptosporidiosis
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Antiprotozoal
Controlled Drug Substance
No
Paromomycin
Summary
Paromomycin is used to treat intestinal amebiasis, both acute and chronic. It's also used as an additional therapy in the management of hepatic coma. However, it's ineffective for extraintestinal amebiasis.
Paromomycin is a broad-spectrum antibiotic that targets bacteria in the intestines. It's poorly absorbed into the bloodstream, meaning it stays in the gut to effectively treat intestinal infections. Its action is similar to that of neomycin, another antibiotic.
For adults, the usual dose is 4 grams daily, divided into regular intervals for five to six days. For children, the usual dose is 25 to 35 mg per kg of body weight daily, administered in three doses with meals for five to ten days.
The most frequently reported side effects of Paromomycin include nausea, abdominal cramps, and diarrhea, especially at doses over 3 grams daily.
Paromomycin is contraindicated in individuals with a history of hypersensitivity reactions to it and in cases of intestinal obstruction. It should be used cautiously in patients with ulcerative bowel lesions to avoid renal toxicity. Overuse can lead to drug-resistant bacteria.
Indications and Purpose
How does Paromomycin work?
Paromomycin works by stopping the growth of bacteria and parasites in the intestines. It belongs to the aminoglycoside class of antibiotics, which interfere with protein production in bacteria, leading to their death. Think of it like a factory shutdown; without protein production, bacteria can't survive. This action helps clear infections like amoebiasis and tapeworms, improving symptoms and health outcomes. Always follow your doctor's instructions for the best results.
Is Paromomycin effective?
Paromomycin is effective in treating certain intestinal infections, such as amoebiasis, which is an infection caused by amoebas, and tapeworm infections. It works by stopping the growth of bacteria and parasites in the intestines. Clinical studies and patient outcomes support its effectiveness for these conditions. Always follow your doctor's instructions for the best results and complete the full course of treatment to ensure the infection is fully cleared.
What is Paromomycin?
Paromomycin is an antibiotic used to treat certain intestinal infections, such as amoebiasis and tapeworm infections. It works by stopping the growth of bacteria and parasites in the intestines. Paromomycin is part of the aminoglycoside class of antibiotics, which are medications that kill bacteria by interfering with their protein production. It's usually used as a complementary treatment with other therapies to effectively manage infections.
Directions for Use
For how long do I take Paromomycin?
Paromomycin is usually used for short-term treatment of acute infections. The duration of use depends on the condition being treated and your doctor's instructions. It's important to complete the full course of treatment to ensure the infection is fully cleared. Always follow your doctor's guidance on how long to take Paromomycin. If you have questions about the duration of your treatment, discuss them with your healthcare provider.
How do I dispose of Paromomycin?
To dispose of Paromomycin, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Paromomycin?
Paromomycin is usually taken orally, with or without food, as directed by your doctor. The dosage and frequency depend on your medical condition and response to treatment. It's important to follow your doctor's instructions carefully. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double the dose to catch up.
How long does it take for Paromomycin to start working?
Paromomycin starts working shortly after you take it, but the time to see full effects can vary. For intestinal infections, you might notice symptom improvement within a few days. The full therapeutic effect may take longer, depending on the severity of the infection and your response to treatment. Always take Paromomycin as prescribed and complete the full course to ensure the infection is fully treated. If symptoms persist, consult your doctor.
How should I store Paromomycin?
Store Paromomycin at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, where moisture can affect its effectiveness. Always keep Paromomycin out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Paromomycin?
The usual dose of Paromomycin for adults is typically 25 to 35 mg per kilogram of body weight per day, divided into three doses. The exact dosage depends on the condition being treated and your doctor's instructions. It's important to follow your doctor's specific dosing instructions for your personal health needs. Always consult your healthcare provider for the correct dosage for your situation.
Warnings and Precautions
Can I take Paromomycin with other prescription drugs?
Paromomycin may interact with other medications that affect kidney function or hearing. It's important to inform your doctor about all the medicines you're taking to avoid potential interactions. Some antibiotics or diuretics, which are medications that help remove excess fluid from the body, may increase the risk of side effects. Always consult your healthcare provider before starting or stopping any medication while taking Paromomycin.
Can Paromomycin be taken safely while breastfeeding?
The safety of Paromomycin while breastfeeding is not well-established. It's unclear if Paromomycin passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest treatment options. Your doctor can help determine if Paromomycin is appropriate for you and your baby, considering the potential risks and benefits. Always inform your healthcare provider about your breastfeeding status before starting any medication.
Can Paromomycin be taken safely while pregnant?
The safety of Paromomycin during pregnancy is not well-established. Limited data is available on its use in pregnant women. It's important to weigh the potential benefits against the risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition. Your doctor can help create a treatment plan that considers your health and the health of your baby.
Does Paromomycin have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Paromomycin include nausea, vomiting, and diarrhea. These effects are usually mild and temporary. Serious adverse effects, like kidney problems or hearing loss, are rare but require immediate medical attention. If you experience any new or worsening symptoms while taking Paromomycin, contact your doctor. They can help determine if the symptoms are related to the medication and provide appropriate care.
Does Paromomycin have any safety warnings?
Paromomycin has important safety warnings. It can cause kidney problems, especially in people with pre-existing kidney issues. If you experience symptoms like decreased urination, swelling, or fatigue, contact your doctor. Paromomycin may also cause hearing loss, especially in high doses or prolonged use. If you notice ringing in your ears or hearing changes, seek medical advice. Always follow your doctor's instructions and report any unusual symptoms.
Is it safe to drink alcohol while taking Paromomycin?
It's best to avoid alcohol while taking Paromomycin. Alcohol can irritate the stomach and may worsen side effects like nausea or vomiting. Drinking alcohol can also affect your body's ability to fight infections. If you choose to drink, do so in moderation and watch for any worsening symptoms. Talk with your doctor about alcohol use while taking Paromomycin to get personalized advice based on your health situation.
Is it safe to exercise while taking Paromomycin?
You can exercise while taking Paromomycin, but listen to your body. If you experience stomach upset or fatigue, consider reducing the intensity of your workouts. Stay hydrated, especially if you have diarrhea, which can lead to dehydration. If you feel dizzy or weak during exercise, stop and rest. Most people can maintain their regular exercise routine while taking Paromomycin, but check with your doctor if you have concerns.
Is it safe to stop Paromomycin?
Paromomycin is usually used for short-term treatment of infections. Stopping it suddenly without completing the prescribed course can lead to incomplete treatment and the return of the infection. Always follow your doctor's instructions on how long to take Paromomycin. If you have concerns about stopping the medication, talk with your doctor. They can provide guidance on safely discontinuing the medication and ensure your infection is fully treated.
Is Paromomycin addictive?
Paromomycin is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Paromomycin works by affecting bacteria in the intestines and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Paromomycin doesn't carry this risk.
Is Paromomycin safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Paromomycin, such as kidney problems or hearing loss. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Dose adjustments may be necessary based on kidney function and overall health. Always consult your doctor before starting Paromomycin to ensure it's safe and appropriate for your specific health needs.
What are the most common side effects of Paromomycin?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Paromomycin include nausea, vomiting, and diarrhea. These effects are usually mild and temporary. If you notice new symptoms after starting Paromomycin, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the symptoms are related to Paromomycin and provide guidance.
Who should avoid taking Paromomycin?
Paromomycin should not be used by people with a known allergy to it or its ingredients. It's also contraindicated in individuals with intestinal obstruction, which is a blockage in the intestines, as it may worsen the condition. Caution is needed in patients with kidney problems, as Paromomycin can affect kidney function. Always consult your doctor about any health conditions you have before starting Paromomycin to ensure it's safe for you.
