Ozanimod
Relapsing-Remitting Multiple Sclerosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Sphingosine 1-phosphate Receptor Modulator
Controlled Drug Substance
No
Ozanimod
Summary
Ozanimod is used to treat relapsing forms of multiple sclerosis and moderately to severely active ulcerative colitis in adults.
Ozanimod works by modulating the immune system. It targets sphingosine 1-phosphate receptors, reducing inflammation and preventing nerve damage.
The usual daily dose for adults is 0.92 mg taken orally once daily after a 7-day titration period. Ozanimod should be taken at the same time each day, with or without food.
Common side effects of Ozanimod include headaches, fatigue, dizziness, nausea, and abdominal pain. More serious effects can include liver injury, infections, and changes in heart rate.
Ozanimod is not recommended for patients with recent heart attacks, certain heart conditions, severe untreated sleep apnea, and those taking MAO inhibitors. It's also not recommended during pregnancy and breastfeeding. It's important to monitor for infections, liver function, and heart rate changes during treatment.
Indications and Purpose
How does Ozanimod work?
Ozanimod works by modulating the immune system. It belongs to a class of drugs called sphingosine 1-phosphate receptor modulators. Think of it like adjusting the volume on a radio. Ozanimod "turns down" the immune system's activity, preventing it from attacking the nervous system. This helps reduce the frequency of relapses and slows the progression of physical disability in multiple sclerosis.
Is Ozanimod effective?
Ozanimod is effective in treating relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. Clinical studies show that Ozanimod reduces the number of relapses and slows the progression of physical disability. It works by modulating the immune system to prevent it from attacking the nervous system. This helps manage symptoms and improve quality of life.
What is Ozanimod?
Ozanimod is a medication used to treat relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. It belongs to a class of drugs called sphingosine 1-phosphate receptor modulators. Ozanimod works by modulating the immune system to prevent it from attacking the nervous system. This helps reduce the frequency of relapses and slows the progression of physical disability.
Directions for Use
For how long do I take Ozanimod?
Ozanimod is usually a long-term medication for managing relapsing forms of multiple sclerosis. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Ozanimod treatment.
How do I dispose of Ozanimod?
To dispose of Ozanimod, bring unused medicine to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent harm to people and the environment.
How do I take Ozanimod?
Take Ozanimod exactly as your doctor prescribes. Usually, it's taken once daily. You can take it with or without food. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Never take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Ozanimod to start working?
Ozanimod starts working in your body shortly after you take it, but you may not notice all the benefits right away. It may take several weeks to see a reduction in relapses and a slowing of disability progression. How quickly the medication works can depend on your overall health and how your body responds. Take it exactly as prescribed for the best results.
How should I store Ozanimod?
Store Ozanimod at room temperature, away from moisture and light. Keep it in its original container, tightly closed, to protect it from damage. Don't store it in humid places like bathrooms. Always keep Ozanimod out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Ozanimod?
The usual starting dose of Ozanimod for adults is 0.23 mg once daily for the first 4 days, then 0.46 mg once daily for the next 3 days. After this, the maintenance dose is 0.92 mg once daily. Always follow your doctor's specific dosing instructions. Dose adjustments may be necessary for special populations, such as the elderly. Your doctor will guide you based on your health needs.
Warnings and Precautions
Can I take Ozanimod with other prescription drugs?
Ozanimod can interact with certain medications, increasing the risk of adverse effects. For example, it may interact with drugs that affect heart rate or immune function. Always inform your doctor about all the medications you take to avoid potential interactions. Your doctor can help manage these risks and adjust your treatment plan as needed.
Can Ozanimod be taken safely while breastfeeding?
Ozanimod is not recommended while breastfeeding. There's limited information on whether it passes into human breast milk. Animal studies suggest it might, raising concerns about potential risks to a baby's developing immune system. If you're taking Ozanimod and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Ozanimod be taken safely while pregnant?
Ozanimod is not recommended during pregnancy. There's limited evidence on its safety, and it may harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby.
Does Ozanimod have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Ozanimod include headache, high blood pressure, and liver enzyme changes. Serious side effects can include infections and heart problems. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Ozanimod and advise on the best course of action.
Does Ozanimod have any safety warnings?
Yes, Ozanimod has important safety warnings. It can increase the risk of infections, liver problems, and slow heart rate. Not adhering to these warnings can lead to serious health issues. If you experience symptoms like fever, yellowing of the skin, or dizziness, seek medical help immediately. Always follow your doctor's advice and report any new or worsening symptoms.
Is it safe to drink alcohol while taking Ozanimod?
It's best to avoid alcohol while taking Ozanimod. Alcohol can increase the risk of liver problems, which is a concern with Ozanimod. Drinking alcohol may also worsen side effects like dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Ozanimod for personalized advice.
Is it safe to exercise while taking Ozanimod?
You can exercise while taking Ozanimod, but be mindful of how your body feels. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water and avoid strenuous activities if you feel unwell. If you notice symptoms like dizziness or unusual fatigue, slow down or stop exercising and rest. Consult your doctor if you have concerns about your specific situation.
Is it safe to stop Ozanimod?
Stopping Ozanimod suddenly can cause your condition to worsen. It's used for long-term management of conditions like multiple sclerosis. Always talk with your doctor before stopping Ozanimod. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Ozanimod addictive?
Ozanimod is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Ozanimod works by modulating the immune system and doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Ozanimod doesn't carry this risk while managing your health condition.
Is Ozanimod safe for the elderly?
The elderly are more vulnerable to medication risks due to age-related changes in the body. Ozanimod is generally safe for elderly patients, but they may experience more side effects like dizziness or infections. Regular monitoring by a doctor is important to manage these risks. Always discuss any concerns with your doctor to ensure safe and effective treatment.
What are the most common side effects of Ozanimod?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Ozanimod include headache, high blood pressure, and liver enzyme changes. These effects vary from person to person. If you notice new symptoms after starting Ozanimod, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Ozanimod?
Don't take Ozanimod if you have had a heart attack, stroke, or certain types of heart failure. It's also contraindicated in people with severe liver problems. These are absolute contraindications due to severe risks. Relative contraindications include conditions like uncontrolled high blood pressure, where caution is needed. Always consult your doctor about these concerns before starting Ozanimod.
