Oxybutynin
Neurogenic Urinary Bladder, Dysuria ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Cholinergic Muscarinic Antagonist
Controlled Drug Substance
No
Oxybutynin
Summary
Oxybutynin is used to treat overactive bladder. It helps reduce symptoms like frequent urination and urgency. It's also used in children with conditions like spina bifida that affect bladder control.
Oxybutynin works by relaxing the bladder muscles. It's an anticholinergic, which means it blocks certain nerve signals to the bladder, helping to control bladder contractions.
For adults, the usual dose is one 5 mg tablet taken two to three times a day. For children over 5, the typical dose is one 5 mg tablet taken twice a day.
Common side effects include dry mouth, constipation, dizziness, and blurred vision. Serious side effects can include difficulty breathing. If you experience serious side effects, seek medical attention immediately.
Oxybutynin is not recommended for patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, or those with hypersensitivity to the drug. It should be used with caution in patients with dementia or Parkinson's disease.
Indications and Purpose
How does Oxybutynin work?
Oxybutynin works by exerting a direct antispasmodic effect on the bladder's smooth muscle and inhibiting the muscarinic action of acetylcholine. This helps relax the bladder muscles, increasing bladder capacity and reducing the frequency of involuntary contractions.
Is Oxybutynin effective?
Clinical studies have shown that Oxybutynin is effective in increasing bladder capacity, reducing the frequency of involuntary bladder contractions, and decreasing urgency and frequency of urination. These effects help manage symptoms of overactive bladder and improve quality of life for patients.
What is Oxybutynin?
Oxybutynin is used to treat overactive bladder by relaxing the bladder muscles, reducing symptoms like frequent urination and urgency. It belongs to a class of medications called anticholinergics, which work by blocking certain nerve signals to the bladder, helping to control bladder contractions.
Directions for Use
For how long do I take Oxybutynin?
Oxybutynin is typically used as a long-term treatment to manage symptoms of overactive bladder. It may take 6-8 weeks to experience the full benefits, and you should continue taking it as prescribed by your doctor, even if you feel well.
How do I take Oxybutynin?
Oxybutynin can be taken with or without food. Take it at the same times every day as directed by your doctor. Avoid grapefruit and grapefruit juice while taking this medication, as they may interact with the drug.
How long does it take for Oxybutynin to start working?
You may notice some improvement in your symptoms within the first 2 weeks of treatment with Oxybutynin. However, it may take 6-8 weeks to experience the full benefit of the medication.
How should I store Oxybutynin?
Store Oxybutynin in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Oxybutynin?
For adults, the usual dose of Oxybutynin is one 5 mg tablet taken two to three times a day, with a maximum of four times a day. For children over 5 years of age, the typical dose is one 5 mg tablet taken twice a day, with a maximum of three times a day. Always follow your doctor's specific dosage instructions.
Warnings and Precautions
Can I take Oxybutynin with other prescription drugs?
Oxybutynin may interact with other anticholinergic drugs, increasing the risk of side effects like dry mouth and constipation. It can also interact with CYP3A4 inhibitors, such as ketoconazole, which may increase Oxybutynin levels in the body. Consult your doctor about all medications you are taking.
Can Oxybutynin be taken safely while breastfeeding?
It is not known if Oxybutynin is excreted in human milk. Caution is advised when administering Oxybutynin to nursing mothers. Consult your doctor to weigh the potential benefits and risks before using this medication while breastfeeding.
Can Oxybutynin be taken safely while pregnant?
There is limited data on the use of Oxybutynin during pregnancy. It should only be used if the potential benefits outweigh the risks. Consult your doctor for personalized advice if you are pregnant or planning to become pregnant while taking this medication.
Is it safe to drink alcohol while taking Oxybutynin?
Drinking alcohol while taking Oxybutynin can enhance the drowsiness caused by the medication. It's important to talk to your doctor about the safe use of alcohol while on this medication to avoid increased side effects.
Is it safe to exercise while taking Oxybutynin?
Oxybutynin may make it harder for your body to cool down when it gets very hot, which can affect your ability to exercise, especially in hot conditions. Avoid exposure to extreme heat and stay hydrated. If you experience symptoms like dizziness or nausea while exercising, stop and consult your doctor.
Is Oxybutynin safe for the elderly?
For elderly patients, especially those who are frail, a lower starting dose of Oxybutynin is recommended due to the potential for prolonged elimination half-life and increased sensitivity to side effects. It's important to monitor for cognitive impairment and adjust the dosage as needed.
Who should avoid taking Oxybutynin?
Oxybutynin is contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and those with hypersensitivity to the drug. It should be used with caution in patients with dementia, Parkinson's disease, and other conditions that may be aggravated by anticholinergic effects.
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