Osimertinib
Non-Small-Cell Lung Carcinoma
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Osimertinib
Summary
Osimertinib is used to treat non-small cell lung cancer, which is a type of lung cancer with specific genetic mutations. It is often prescribed when other treatments have failed or are no longer effective.
Osimertinib works by blocking tyrosine kinases, which are proteins that help cancer cells grow and spread. By inhibiting these proteins, it slows down or stops the growth of cancer cells.
The usual starting dose of Osimertinib for adults is 80 mg taken once daily. It can be taken with or without food, and the tablet should be swallowed whole, not crushed or chewed.
Common side effects of Osimertinib include diarrhea, which is frequent loose or watery stools, rash, which is a skin irritation, and dry skin, which is skin that lacks moisture.
Osimertinib can cause serious lung, heart, and eye problems. It is not recommended during pregnancy due to potential harm to the baby. Always inform your doctor about any other medications you are taking to avoid interactions.
Indications and Purpose
How does Osimertinib work?
Osimertinib works by blocking specific proteins called tyrosine kinases, which are involved in the growth and spread of cancer cells. By inhibiting these proteins, Osimertinib helps slow down or stop the growth of cancer cells. This action makes it effective in treating non-small cell lung cancer with certain genetic mutations.
Is Osimertinib effective?
Osimertinib is effective in treating non-small cell lung cancer with specific genetic mutations. Clinical studies show it improves survival rates and reduces tumor size. Your doctor will monitor your progress with regular check-ups and tests to ensure the medication is working effectively for your condition.
What is Osimertinib?
Osimertinib is a medication used to treat non-small cell lung cancer with specific genetic mutations. It belongs to a class of drugs called tyrosine kinase inhibitors, which block signals that cancer cells need to grow. Osimertinib is used when other treatments have not worked or are no longer effective.
Directions for Use
For how long do I take Osimertinib?
Osimertinib is usually a long-term medication for managing non-small cell lung cancer. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Osimertinib treatment.
How do I dispose of Osimertinib?
Bring unused Osimertinib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Osimertinib?
Osimertinib is usually taken once daily, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Then, skip the missed dose and continue your regular schedule. Never take two doses at once. Always follow your doctor's specific instructions regarding diet and fluid intake while taking this medication.
How long does it take for Osimertinib to start working?
Osimertinib begins working in your body shortly after you take it, but noticeable effects may take several weeks. The time it takes to achieve full therapeutic effect can vary based on individual factors like overall health and cancer progression. Regular check-ups and tests help monitor the medication's effectiveness.
How should I store Osimertinib?
Store Osimertinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Osimertinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Osimertinib?
The usual starting dose of Osimertinib for adults is 80 mg once daily. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Osimertinib with other prescription drugs?
Osimertinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Drugs that affect liver enzymes, like some antifungals or antibiotics, may alter Osimertinib levels. Always inform your doctor about all medications you take to manage potential interactions effectively.
Can Osimertinib be taken safely while breastfeeding?
Osimertinib is not recommended while breastfeeding. Limited information is available on whether it passes into human breast milk. If you're taking Osimertinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Osimertinib be taken safely while pregnant?
Osimertinib is not recommended during pregnancy due to potential harm to the unborn baby. Limited human data is available, but animal studies suggest risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options.
Does Osimertinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Osimertinib include diarrhea, rash, and dry skin. Serious effects like lung problems or heart issues are less common but require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Osimertinib.
Does Osimertinib have any safety warnings?
Osimertinib has important safety warnings. It can cause serious lung problems, heart issues, and eye problems. If you experience new or worsening symptoms like shortness of breath, chest pain, or vision changes, seek medical help immediately. Regular monitoring by your doctor is essential to manage these risks.
Is it safe to drink alcohol while taking Osimertinib?
It's best to avoid alcohol while taking Osimertinib. Alcohol can worsen side effects like dizziness or nausea. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Osimertinib for personalized advice.
Is it safe to exercise while taking Osimertinib?
You can exercise while taking Osimertinib, but be cautious. This medication can cause side effects like fatigue or dizziness, which might affect your exercise capacity. To exercise safely, stay hydrated and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Osimertinib?
Stopping Osimertinib suddenly can cause your condition to worsen. Always talk with your doctor before stopping the medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Osimertinib addictive?
Osimertinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that Osimertinib doesn't carry this risk while managing your health condition.
Is Osimertinib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Osimertinib, such as heart or lung issues. Regular monitoring by a doctor is important to manage these risks. Always consult your doctor about any concerns or conditions that might affect your treatment.
What are the most common side effects of Osimertinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Osimertinib include diarrhea, rash, and dry skin. These effects vary from person to person. If you notice new symptoms after starting Osimertinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Osimertinib?
Don't take Osimertinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Osimertinib is not recommended for use during pregnancy due to potential harm to the baby. Always consult your doctor about any concerns or conditions that might affect your treatment.
