Osilodrostat
Cushing Syndrome
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Cortisol Synthesis Inhibitor
Controlled Drug Substance
No
Osilodrostat
Summary
Osilodrostat is used to treat Cushing's syndrome, which is a condition where the body produces too much cortisol, a hormone that helps control stress and metabolism. It helps lower cortisol levels, improving symptoms like weight gain, high blood pressure, and fatigue.
Osilodrostat works by blocking an enzyme called 11-beta-hydroxylase, which is involved in cortisol production. This action helps reduce cortisol levels, managing symptoms of Cushing's syndrome and restoring hormone balance in the body.
The usual starting dose of Osilodrostat for adults is 2 mg taken twice daily. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 30 mg twice daily. Always follow your doctor's specific dosing instructions.
Common side effects of Osilodrostat include nausea, fatigue, and headache. These effects vary from person to person. If you notice new symptoms after starting Osilodrostat, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Osilodrostat can cause low cortisol levels, leading to symptoms like fatigue, nausea, or dizziness. It's contraindicated in patients with severe liver impairment. Caution is needed for those with heart problems, as it may affect heart rhythm. Always consult your doctor about these concerns before starting Osilodrostat.
Indications and Purpose
How does Osilodrostat work?
Osilodrostat works by blocking an enzyme called 11-beta-hydroxylase, which is involved in cortisol production. Think of it like turning down the volume on a radio. By reducing cortisol production, Osilodrostat helps manage symptoms of Cushing's syndrome, such as weight gain and high blood pressure. This medication helps restore balance to hormone levels in the body.
Is Osilodrostat effective?
Osilodrostat is effective for treating Cushing's syndrome, which is a condition where the body produces too much cortisol. Clinical studies show it significantly reduces cortisol levels, improving symptoms and quality of life. Regular monitoring by your doctor ensures the medication is working effectively for your condition.
What is Osilodrostat?
Osilodrostat is a medication used to treat Cushing's syndrome, which is a condition where the body produces too much cortisol. It works by blocking an enzyme involved in cortisol production, helping to lower cortisol levels. Osilodrostat is part of a class of drugs called cortisol synthesis inhibitors. It's used to manage symptoms and improve quality of life in people with Cushing's syndrome.
Directions for Use
For how long do I take Osilodrostat?
Osilodrostat is usually a long-term medication for managing Cushing's syndrome. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Osilodrostat treatment.
How do I dispose of Osilodrostat?
Dispose of Osilodrostat by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Osilodrostat?
Take Osilodrostat exactly as your doctor prescribes. It's usually taken twice daily, once in the morning and once in the evening, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Osilodrostat to start working?
Osilodrostat begins working shortly after you start taking it, but it may take several weeks to see significant improvements in symptoms. The time it takes to achieve full therapeutic effects can vary based on individual factors like your condition's severity and overall health. Regular monitoring by your doctor helps track progress and adjust treatment as needed.
How should I store Osilodrostat?
Store Osilodrostat at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Osilodrostat out of children's reach to prevent accidental swallowing. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Osilodrostat?
The usual starting dose of Osilodrostat for adults is 2 mg twice daily. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 30 mg twice daily. Always follow your doctor's specific dosing instructions. Special populations, such as children or the elderly, may require different dosing, so consult your healthcare provider for personalized advice.
Warnings and Precautions
Can I take Osilodrostat with other prescription drugs?
Osilodrostat can interact with medications that affect heart rhythm, increasing the risk of arrhythmias, which are irregular heartbeats. It may also interact with drugs that affect liver enzymes, altering Osilodrostat levels in the body. Always inform your doctor about all medications you take to prevent interactions and ensure safe treatment.
Can Osilodrostat be taken safely while breastfeeding?
Osilodrostat is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. While specific reports of harm to breastfed babies are lacking, potential risks can't be ruled out. If you're taking Osilodrostat and want to breastfeed, talk with your doctor about safer medication options.
Can Osilodrostat be taken safely while pregnant?
Osilodrostat isn't recommended during pregnancy due to limited safety data. Animal studies suggest potential risks, but human data is lacking. Uncontrolled Cushing's syndrome during pregnancy can cause serious problems for both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition.
Does Osilodrostat have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Osilodrostat include nausea, fatigue, and headache. These effects vary in frequency and severity. Serious side effects, like low cortisol levels, require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Osilodrostat.
Does Osilodrostat have any safety warnings?
Yes, Osilodrostat has important safety warnings. It can cause low cortisol levels, which may lead to symptoms like fatigue, nausea, or dizziness. Regular monitoring of cortisol levels is necessary. Not adhering to these warnings can result in serious health issues. Always follow your doctor's instructions and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Osilodrostat?
It's best to avoid alcohol while taking Osilodrostat. Alcohol can interfere with the medication's effectiveness and may worsen side effects like dizziness or nausea. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or nausea. Talk with your doctor about alcohol use while taking Osilodrostat.
Is it safe to exercise while taking Osilodrostat?
You can exercise while taking Osilodrostat, but be cautious. This medication can cause fatigue or dizziness, which might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Osilodrostat?
Stopping Osilodrostat suddenly can cause serious problems. It's used long-term for conditions like Cushing's syndrome. Stopping it abruptly may worsen your condition. Always talk with your doctor before stopping Osilodrostat. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is Osilodrostat addictive?
Osilodrostat is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting hormone levels in your body, not brain chemistry, so it doesn't lead to addiction. If you have concerns about medication dependence, you can feel confident that Osilodrostat doesn't carry this risk.
Is Osilodrostat safe for the elderly?
Elderly patients may be more vulnerable to side effects of Osilodrostat, such as low cortisol levels, which can cause fatigue and dizziness. Regular monitoring by a doctor is important to ensure safety. Adjustments in dosing may be necessary based on individual health conditions. Always consult your doctor for personalized advice.
What are the most common side effects of Osilodrostat?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Osilodrostat include nausea, fatigue, and headache. These effects vary from person to person. If you notice new symptoms after starting Osilodrostat, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Osilodrostat?
Don't take Osilodrostat if you're allergic to it or its ingredients. It's contraindicated in patients with severe liver impairment. Caution is needed for those with heart problems, as it may affect heart rhythm. Always consult your doctor about these concerns and inform them of your medical history before starting Osilodrostat.
