Olutasidenib
Acute Myeloid Leukemia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Olutasidenib
Summary
Olutasidenib is used to treat adults with relapsed or refractory acute myeloid leukemia (AML) that has a specific mutation called IDH1. This means the leukemia has come back or has not improved after previous treatments.
Olutasidenib works by targeting and inhibiting the mutated IDH1 enzyme. This reduces the production of a compound called 2-hydroxyglutarate, which contributes to the growth of cancer cells. By doing this, Olutasidenib helps slow down or stop the progression of the leukemia.
The usual dose for adults is 150 mg taken orally, twice daily. Olutasidenib should be taken on an empty stomach, either 1 hour before or 2 hours after a meal.
Common side effects include nausea, fatigue, constipation, and rash. Serious adverse effects include differentiation syndrome, which includes symptoms like fever and weight gain, and hepatotoxicity, which can lead to liver damage.
Olutasidenib can cause potentially life-threatening conditions like differentiation syndrome and hepatotoxicity. Patients should be monitored for these conditions and any symptoms should be reported immediately. There are no specific contraindications, but patients should inform their doctor of any allergies or existing liver or kidney conditions.
Indications and Purpose
How does Olutasidenib work?
Olutasidenib works by inhibiting specific enzymes that promote cancer cell growth. This action helps slow down or stop the progression of certain types of cancer. Think of it like blocking a pathway that cancer cells use to grow, helping to control the disease.
Is Olutasidenib effective?
Olutasidenib is effective for treating certain types of cancer by inhibiting specific enzymes that promote cancer cell growth. Clinical studies support its effectiveness in improving health outcomes for patients with these conditions. Always follow your doctor's advice for the best results.
What is Olutasidenib?
Olutasidenib is a medication used to treat certain types of cancer. It works by inhibiting specific enzymes that promote cancer cell growth. This helps slow down or stop the progression of the disease. Always follow your doctor's advice when taking Olutasidenib.
Directions for Use
For how long do I take Olutasidenib?
Olutasidenib is usually taken long-term for managing certain types of cancer. The duration depends on your response to treatment and any side effects. Always follow your doctor's advice and talk with them before changing or stopping your treatment.
How do I dispose of Olutasidenib?
Dispose of Olutasidenib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash.
How do I take Olutasidenib?
Take Olutasidenib exactly as your doctor prescribes. It's usually taken once daily, with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Never take two doses at once. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Olutasidenib to start working?
Olutasidenib starts working in your body shortly after you take it, but noticeable benefits may take weeks or months. The time it takes to see full effects can vary based on your condition and overall health. Follow your doctor's instructions for the best results.
How should I store Olutasidenib?
Store Olutasidenib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep it out of children's reach to prevent accidental swallowing.
What is the usual dose of Olutasidenib?
The usual starting dose of Olutasidenib for adults is determined by your doctor based on your specific condition. It's typically taken once daily. Your doctor may adjust your dose as needed. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Olutasidenib with other prescription drugs?
Olutasidenib may interact with other medications, increasing the risk of liver problems or reducing effectiveness. Always inform your doctor about all the medicines you take to avoid potential interactions and ensure safe treatment.
Can Olutasidenib be taken safely while breastfeeding?
Olutasidenib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. If you're taking Olutasidenib and want to breastfeed, talk with your doctor about safer medication options.
Can Olutasidenib be taken safely while pregnant?
Olutasidenib is not recommended during pregnancy due to potential risks to the unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition during this time.
Does Olutasidenib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Olutasidenib include nausea and fatigue. Serious effects like liver problems are less common but require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Olutasidenib.
Does Olutasidenib have any safety warnings?
Yes, Olutasidenib has important safety warnings. It can cause liver problems, so regular liver function tests are needed. If you experience symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, contact your doctor immediately. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Olutasidenib?
It's best to avoid alcohol while taking Olutasidenib. Alcohol can increase the risk of liver problems, which are a concern with this medication. Talk with your doctor about alcohol use while taking Olutasidenib to get personalized advice.
Is it safe to exercise while taking Olutasidenib?
You can exercise while taking Olutasidenib, but be mindful of how your body feels. If you experience dizziness or fatigue, slow down or stop exercising and rest. Drink plenty of water before, during, and after physical activity. Consult your doctor if you have concerns.
Is it safe to stop Olutasidenib?
Stopping Olutasidenib suddenly can cause your condition to worsen. Always talk with your doctor before stopping the medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is Olutasidenib addictive?
Olutasidenib is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, discuss them with your doctor.
Is Olutasidenib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Olutasidenib, such as liver problems. Regular monitoring and dose adjustments may be necessary. Always consult your doctor about the risks and benefits of using Olutasidenib if you are elderly.
What are the most common side effects of Olutasidenib?
Side effects are unwanted reactions to a medication. Common side effects of Olutasidenib include nausea and fatigue. These effects vary from person to person. If you notice new symptoms after starting Olutasidenib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Olutasidenib?
Do not take Olutasidenib if you're allergic to it or its ingredients. It's not recommended for people with severe liver problems. Always consult your doctor about any concerns or conditions you have before starting Olutasidenib.
