Niraparib
Ovarian Neoplasms, Fallopian Tube Neoplasms ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Poly(ADP-Ribose) Polymerase Inhibitor
Controlled Drug Substance
No
Niraparib
Summary
Niraparib is used for the maintenance treatment of advanced ovarian cancer and recurrent germline BRCA-mutated ovarian cancer. It is also used for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who have responded to platinum-based chemotherapy.
Niraparib works by inhibiting PARP enzymes, which are involved in DNA repair. This leads to increased DNA damage and death of cancer cells, particularly those with deficiencies in DNA repair mechanisms, which helps slow the growth of the tumor.
For adults, the recommended dosage of Niraparib is 200 mg or 300 mg taken orally once daily, depending on the patient's weight and platelet count. It should be taken at the same time each day, with or without food.
Common side effects of Niraparib include nausea, decreased appetite, fatigue, constipation, and headaches. Serious adverse effects include myelodysplastic syndrome/acute myeloid leukemia and hypertension.
Niraparib can cause fetal harm and is not recommended during pregnancy. Women should not breastfeed during treatment and for 1 month after the last dose. It can also cause dizziness and fatigue, which may impair your ability to drive. Patients should be monitored for myelodysplastic syndrome/acute myeloid leukemia, bone marrow suppression, hypertension, and posterior reversible encephalopathy syndrome.
Indications and Purpose
How does Niraparib work?
Niraparib works by inhibiting a protein called PARP, which helps cancer cells repair DNA damage. By blocking this protein, Niraparib prevents cancer cells from fixing themselves, leading to their death. This mechanism helps slow the progression of certain types of ovarian cancer. Think of it like cutting off a lifeline that cancer cells rely on to survive.
Is Niraparib effective?
Niraparib is effective in treating certain types of ovarian cancer. It works by inhibiting a protein that helps cancer cells repair themselves, leading to their death. Clinical studies show Niraparib can delay cancer progression and improve survival rates. Your doctor will monitor your response to the medication to ensure it's working effectively for your condition.
What is Niraparib?
Niraparib is a medication used to treat certain types of ovarian cancer. It belongs to a class of drugs called PARP inhibitors, which help prevent cancer cells from repairing themselves, leading to their death. Niraparib is primarily used for maintenance therapy in patients who have responded to initial treatment. It can be used alone or with other therapies.
Directions for Use
For how long do I take Niraparib?
Niraparib is usually taken long-term for managing certain types of ovarian cancer. The duration depends on your response to treatment and any side effects. Your doctor will guide you on how long to continue taking Niraparib. Always follow your doctor's advice and discuss any concerns about your treatment duration.
How do I dispose of Niraparib?
Dispose of unused Niraparib through a drug take-back program or collection site at a pharmacy or hospital. If these options aren't available, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Niraparib?
Take Niraparib once daily, preferably at the same time each day. You can take it with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Niraparib to start working?
Niraparib starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to become noticeable. The time it takes to work can vary based on individual factors like overall health and cancer type. Regular check-ups with your doctor help monitor your progress and adjust treatment as needed.
How should I store Niraparib?
Store Niraparib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Niraparib?
The usual starting dose of Niraparib for adults is 300 mg once daily. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 300 mg daily. Always follow your doctor's specific dosing instructions. Dose adjustments may be necessary for special populations, such as those with certain health conditions or the elderly.
Warnings and Precautions
Can I take Niraparib with other prescription drugs?
Niraparib may interact with certain medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all the medications you're taking. They can help identify potential interactions and adjust your treatment plan accordingly. Always consult your healthcare provider before starting or stopping any medication while on Niraparib.
Can Niraparib be taken safely while breastfeeding?
Niraparib is not recommended while breastfeeding. It's unclear if the medication passes into breast milk, but it could pose risks to a nursing infant. If you're taking Niraparib and wish to breastfeed, discuss safer medication options with your doctor. They can help you find a treatment plan that allows you to nurse safely.
Can Niraparib be taken safely while pregnant?
Niraparib is not recommended during pregnancy due to potential harm to the unborn baby. There is limited evidence on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a plan that protects both you and your baby.
Does Niraparib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Niraparib include nausea, fatigue, and low blood cell counts. These effects vary in frequency and severity. Serious side effects, like high blood pressure or severe allergic reactions, require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Niraparib.
Does Niraparib have any safety warnings?
Yes, Niraparib has important safety warnings. It can cause high blood pressure and low blood cell counts, which may lead to fatigue or increased infection risk. Regular blood tests are needed to monitor these effects. Not adhering to safety warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Niraparib?
It's best to avoid alcohol while taking Niraparib. Alcohol can increase the risk of side effects like nausea and dizziness. It may also interfere with the effectiveness of the medication. If you choose to drink, limit your intake and watch for any adverse reactions. Discuss alcohol use with your doctor for personalized advice.
Is it safe to exercise while taking Niraparib?
You can exercise while taking Niraparib, but be mindful of side effects like fatigue or dizziness. These might limit your exercise capacity. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Stay hydrated and rest if you experience any symptoms. Consult your doctor if you have concerns about exercising while on Niraparib.
Is it safe to stop Niraparib?
Stopping Niraparib suddenly can affect your treatment outcome. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Niraparib. They might suggest a gradual reduction or alternative treatment to ensure your health is protected.
Is Niraparib addictive?
Niraparib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting cancer cells and does not affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Niraparib doesn't carry this risk.
Is Niraparib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Niraparib, such as fatigue and low blood cell counts. These effects require careful monitoring. Niraparib is generally safe for elderly patients, but they may experience more frequent negative outcomes. Regular check-ups with your doctor help ensure safe and effective treatment.
What are the most common side effects of Niraparib?
Side effects are unwanted reactions to a medication. Common side effects of Niraparib include nausea, fatigue, and low blood cell counts. These occur in more than 10% of patients. If you experience new symptoms after starting Niraparib, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking Niraparib?
Niraparib should not be used if you have severe liver impairment or are allergic to any of its ingredients. These are absolute contraindications. Relative contraindications include conditions where caution is needed, such as moderate liver impairment. Always consult your doctor about your medical history before starting Niraparib to ensure it's safe for you.
