Nicotine
Ulcerative Colitis, Tobacco Use Disorder
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Cholinergic Nicotinic Agonist
Controlled Drug Substance
NO

Nicotine
Learn more about this medicine -
Click HereSummary
Nicotine is primarily used to help people quit smoking. It replaces the nicotine obtained from cigarettes, reducing withdrawal symptoms and cravings.
Nicotine stimulates the nervous system, releasing dopamine which creates feelings of pleasure and reward. This can lead to addiction. It can increase alertness, reduce anxiety, or create a sense of relaxation.
Nicotine can be taken in several forms like cigarettes, patches, gum, lozenges, nasal spray, and inhalers. The medicine is usually taken for 3 months. For the first six weeks, adults should take at least 9 but no more than 20 lozenges each day.
Common side effects of nicotine include headaches, nausea, vomiting, stomach discomfort, mood swings, anxiety, and sleep disruption. Overuse or withdrawal can lead to these symptoms.
If you have heart problems, high blood pressure, ulcers, diabetes, or a history of seizures, talk to your doctor before using it. Pregnant and breastfeeding women should consult their doctor before use. If you experience mouth sores, persistent stomach upset, a bad sore throat, a fast or irregular heartbeat, or have an allergic reaction, stop using it and see a doctor right away.
Indications and Purpose
What is Nicotine used for?
This medicine helps people quit smoking by replacing nicotine. We don't know all the risks for kids. See a doctor first if you have heart problems, high blood pressure, stomach ulcers, diabetes, seizures, or take medicine for depression or asthma, or are on a low-sodium diet or other quit-smoking medicine. Stop taking it and see a doctor right away if you get mouth sores, ongoing indigestion, a really bad sore throat, irregular heartbeat, fast heartbeat, signs of too much nicotine, or an allergic reaction.
How does Nicotine work?
Nicotine stimulates the nervous system, releasing dopamine, which creates feelings of pleasure and reward, leading to addiction.
Is Nicotine effective?
Yes, nicotine is effective in providing a stimulant effect, increasing alertness, and reducing stress, but it is highly addictive.
How does one know if Nicotine is working?
You may experience increased alertness, reduced anxiety, or a sense of relaxation. In the case of using nicotine to quit smoking, you may feel reduced cravings.
Directions for Use
What is the usual dose of Nicotine?
For the first six weeks, grown-ups should take at least 9, but no more than 20, of these lozenges each day. Don't take more than 5 lozenges in any six-hour period. Kids need to ask a doctor before using them.
How do I take Nicotine?
Nicotine can be taken in several forms, including:
- Cigarettes or cigars – By smoking.
- Nicotine patches – Applied to the skin, delivering a steady dose throughout the day.
- Nicotine gum – Chewed to release nicotine for absorption through the mouth.
- Nicotine lozenges – Dissolved in the mouth for gradual nicotine absorption.
- Nicotine nasal spray – Sprayed into the nose for quick absorption.
- Nicotine inhalers – Used to inhale a vaporized form of nicotine.
Each form is designed to provide nicotine without smoking, often used to help quit smoking. It's important to follow product instructions carefully to avoid misuse.
For how long do I take Nicotine?
This medicine is usually taken for 3 months (12 weeks). Instructions are in the guide. If you still need it after 3 months to quit smoking, talk to your doctor.
How long does it take for Nicotine to start working?
Nicotine starts working almost immediately after it is consumed:
- Smoking or vaping: Nicotine is absorbed quickly into the bloodstream through the lungs, and effects are felt within seconds.
- Nicotine gum or lozenges: It may take a few minutes for nicotine to be absorbed through the mouth.
- Nicotine patches: The patch delivers a steady amount of nicotine over time, with effects starting after 30 minutes to 1 hour, but the full effect may take several hours.
The speed of onset depends on the method of use.
How should I store Nicotine?
Keep this item in a cool, dark place. The ideal temperature is between 68 and 77 degrees Fahrenheit (or 20 to 25 degrees Celsius). Make sure the container's lid is on tight.
Warnings and Precautions
Who should avoid taking Nicotine?
This medicine helps smokers quit. If you're pregnant, breastfeeding, allergic to soy, have heart problems, high blood pressure, stomach ulcers, diabetes, seizures, or are on other medicines (like for depression or asthma), talk to your doctor before taking it. If you have a sodium-restricted diet, also check with your doctor. Stop taking it and see a doctor right away if you get mouth sores, persistent indigestion, a really bad sore throat, an irregular heartbeat, feel sick (nausea, vomiting, dizziness, diarrhea, weakness, fast heartbeat), or have an allergic reaction. Keep it away from kids and pets.
Can I take Nicotine with other prescription drugs?
This medicine might not work well or could cause problems if you're also taking certain other medicines. This includes medicines to help you quit smoking (that aren't nicotine patches), medicines for depression, and asthma inhalers. Your doctor might need to change the amount of medicine you take to keep you safe.
Can I take Nicotine with vitamins or supplements?
Nicotine replacement medicine can interact badly with some other medicines and health conditions. If you have heart problems, high blood pressure, stomach ulcers, diabetes, or take medicine for depression or asthma, talk to your doctor *before* starting nicotine replacement. Also, let your doctor know if you're using any other stop-smoking medications. It's best to check with your doctor to make sure it's safe for you.
Can Nicotine be taken safely while pregnant?
Pregnant women shouldn't use nicotine patches or gum to quit smoking unless their doctor says it's okay. We don't know for sure how these medicines might affect the baby, because there haven't been enough studies on pregnant people.
Can Nicotine be taken safely while breastfeeding?
If you're breastfeeding and need this medicine, talk to your doctor first. It's thought to be safer than smoking, but we don't know all the risks to your baby. Quitting smoking is best for your child's health, so try to stop smoking without this medicine if you can.
Is Nicotine safe for the elderly?
Nicotine replacement helps you quit smoking, but it's not risk-free. While it's safer than smoking, it can still affect your health, especially if you have certain conditions. If you have heart problems, high blood pressure, ulcers, diabetes, or a history of seizures, talk to your doctor before using it. Also, tell your doctor or pharmacist if you're taking other medicines, like those for depression or asthma, or using other quit-smoking aids. If you get mouth sores, persistent stomach upset, a bad sore throat, a fast or irregular heartbeat, feel sick, or have an allergic reaction, stop using it and see a doctor right away. If you are on a low-sodium diet, you should also check with your doctor before use.
Is it safe to exercise while taking Nicotine?
While nicotine itself doesn't prevent exercise, it can put additional stress on the heart and circulatory system, so moderate activity and caution are advised.
Is it safe to drink alcohol while taking Nicotine?
Quitting smoking is hard. Alcohol can make it even harder because it makes you want to smoke more. So, when you're trying to quit, it's best to avoid alcohol, especially at the beginning. If you do drink, try to be around people who don't smoke.