Nicorandil
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Arteriolar Vasodilator
Controlled Drug Substance
NO
Nicorandil
Summary
Nicorandil is used to treat angina, which is chest pain caused by reduced blood flow to the heart. It may also be prescribed for other heart-related conditions as determined by your doctor.
Nicorandil works by relaxing blood vessels, which improves blood flow and reduces the heart's workload. This helps relieve angina, which is chest pain caused by reduced blood flow to the heart.
The usual starting dose of Nicorandil for adults is 10 mg taken twice daily. It can be taken with or without food. Swallow the tablets whole; do not crush or chew them.
Common side effects of Nicorandil include headaches and dizziness. These occur in more than 10% of people taking the medication.
Nicorandil can cause serious skin ulcers, especially in the mouth, and may lead to low blood pressure, which is when your blood pressure drops too low. It's contraindicated in people with low blood pressure and certain heart conditions.
Indications and Purpose
How does Nicorandil work?
Nicorandil works by relaxing blood vessels, which improves blood flow and reduces the heart's workload. It acts like opening a valve to allow more blood to flow through, easing the pressure on the heart. This helps relieve angina, which is chest pain caused by reduced blood flow to the heart. By improving blood flow, Nicorandil helps prevent angina attacks and improves heart health.
Is Nicorandil effective?
Yes, Nicorandil is effective for treating angina, which is chest pain caused by reduced blood flow to the heart. It works by relaxing blood vessels, improving blood flow, and reducing the heart's workload. Clinical studies support its effectiveness in reducing the frequency and severity of angina attacks. Always follow your doctor's instructions to ensure the medication works effectively for your condition.
What is Nicorandil?
Nicorandil is a medication used to treat angina, which is chest pain caused by reduced blood flow to the heart. It belongs to a class of drugs called vasodilators, which work by relaxing blood vessels to improve blood flow and reduce the heart's workload. Nicorandil is primarily used for angina but may also be prescribed for other heart-related conditions as determined by your doctor.
Directions for Use
For how long do I take Nicorandil?
Nicorandil is usually a long-term medication for managing chronic conditions like angina, which is chest pain caused by reduced blood flow to the heart. You'll typically take Nicorandil every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could worsen your condition. Always talk with your doctor before changing or stopping your Nicorandil treatment.
How do I dispose of Nicorandil?
Dispose of Nicorandil by taking it to a drug take-back program or collection site at a pharmacy or hospital. If these options aren't available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and then throw it away. This helps prevent accidental ingestion or environmental harm.
How do I take Nicorandil?
Take Nicorandil as prescribed by your doctor, usually twice daily. You can take it with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Avoid alcohol, as it can increase the risk of side effects. Always follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
How long does it take for Nicorandil to start working?
Nicorandil starts working within an hour of taking it, providing relief from angina, which is chest pain caused by reduced blood flow to the heart. The full therapeutic effect may take a few days to become noticeable. Factors like your overall health and other medications can affect how quickly you feel the benefits. Always take Nicorandil as prescribed for the best results.
How should I store Nicorandil?
Store Nicorandil at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, as moisture can affect its effectiveness. Always keep Nicorandil out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Nicorandil?
The usual starting dose of Nicorandil for adults is 10 mg taken twice daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 40 mg per day. For elderly patients or those with specific health conditions, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions to ensure the medication is effective and safe for your health needs.
Warnings and Precautions
Can I take Nicorandil with other prescription drugs?
Nicorandil can interact with certain medications, increasing the risk of side effects. Major interactions include other vasodilators, which are drugs that widen blood vessels, and medications that lower blood pressure. These combinations can lead to dangerously low blood pressure. Always inform your doctor about all medications you're taking to avoid interactions and ensure your treatment is safe and effective.
Can Nicorandil be taken safely while breastfeeding?
The safety of Nicorandil while breastfeeding is not well-established. It's unclear if the medication passes into breast milk or affects milk supply. Due to limited information, it's best to consult your doctor before using Nicorandil while breastfeeding. They can help assess the risks and benefits and suggest safer alternatives if necessary to ensure the well-being of both you and your baby.
Can Nicorandil be taken safely while pregnant?
The safety of Nicorandil during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, discuss with your doctor the safest treatment options for managing your condition. They can help create a plan that protects both you and your baby.
Does Nicorandil have adverse effects?
Yes, Nicorandil can cause adverse effects, which are unwanted reactions to a medication. Common adverse effects include headaches and dizziness. Serious side effects, though rare, include skin ulcers and low blood pressure. If you experience any severe or persistent symptoms, contact your doctor immediately. They can help determine if these effects are related to Nicorandil and provide appropriate treatment or adjustments to your medication.
Does Nicorandil have any safety warnings?
Yes, Nicorandil has important safety warnings. It can cause serious skin ulcers, especially in the mouth, which require immediate medical attention. Nicorandil may also lead to low blood pressure, which is when your blood pressure drops too low, causing dizziness or fainting. Not adhering to these warnings can result in severe health issues. Always follow your doctor's advice and report any unusual symptoms promptly.
Is it safe to drink alcohol while taking Nicorandil?
It's best to avoid alcohol while taking Nicorandil. Alcohol can increase the risk of side effects like dizziness and low blood pressure, which is when your blood pressure drops too low. If you choose to drink occasionally, limit your intake and watch for warning signs like dizziness or fainting. Always talk with your doctor about alcohol use while taking Nicorandil to get personalized advice.
Is it safe to exercise while taking Nicorandil?
Yes, you can exercise while taking Nicorandil, but be cautious. Nicorandil can cause dizziness or low blood pressure, which might affect your exercise capacity. Start with light activities and gradually increase intensity. Stay hydrated and watch for symptoms like dizziness or unusual fatigue. If you experience these, stop exercising and rest. Consult your doctor for personalized advice on safe exercise routines.
Is it safe to stop Nicorandil?
Stopping Nicorandil suddenly can be risky. It's used long-term for conditions like angina, which is chest pain caused by reduced blood flow to the heart. Stopping it abruptly may worsen your condition or cause a rebound effect, leading to increased chest pain. Always consult your doctor before stopping Nicorandil. They may suggest a gradual reduction or an alternative treatment to ensure your condition remains stable.
Is Nicorandil addictive?
No, Nicorandil is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Nicorandil works by relaxing blood vessels to improve blood flow, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Nicorandil doesn't carry this risk.
Is Nicorandil safe for the elderly?
Elderly individuals are more vulnerable to medication side effects due to age-related changes in the body. Nicorandil is generally safe for the elderly, but they may experience more pronounced side effects like dizziness or low blood pressure. Regular monitoring and dose adjustments may be necessary. Always consult a doctor to ensure the medication is safe and effective for elderly patients.
What are the most common side effects of Nicorandil?
Common side effects of Nicorandil include headaches and dizziness. These occur in more than 10% of people taking the medication. Side effects are unwanted reactions that can happen when taking a medication. If you experience new symptoms after starting Nicorandil, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication to ensure your treatment remains safe and effective.
Who should avoid taking Nicorandil?
Do not take Nicorandil if you are allergic to it or its ingredients. It's contraindicated in people with low blood pressure, which is when your blood pressure is too low, and those with certain heart conditions. Caution is needed if you have a history of ulcers or are taking medications that increase potassium levels. Always consult your doctor about your medical history before starting Nicorandil.
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