Nicardipine
Hypertension, Variant Angina Pectoris ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Dihydropyridine Calcium Channel Blocker
Controlled Drug Substance
No
Nicardipine
Summary
Nicardipine is used to treat high blood pressure and control angina, which is chest pain.
Nicardipine is a calcium channel blocker. It works by relaxing blood vessels, making it easier for the heart to pump blood. This increases the supply of blood and oxygen to the heart, helping to control chest pain.
For adults, the usual dose of Nicardipine is 20 to 40 mg taken three times daily. The dose may be adjusted based on the individual's response and medical condition.
Common side effects of Nicardipine include headache, dizziness, flushing, and nausea. Serious adverse effects may include swelling of the face, difficulty breathing, and increased chest pain.
Nicardipine is contraindicated in patients with hypersensitivity to the drug and those with advanced aortic stenosis. It should be used cautiously in patients with heart failure, liver or kidney disease. Patients should be monitored for increased angina and abrupt withdrawal of beta-blockers should be avoided.
Indications and Purpose
How does Nicardipine work?
Nicardipine is a calcium channel blocker that inhibits the influx of calcium ions into cardiac and smooth muscle cells. This action relaxes blood vessels, reducing the workload on the heart and lowering blood pressure. It also increases blood and oxygen supply to the heart, helping to control angina.
Is Nicardipine effective?
Nicardipine is a calcium channel blocker that effectively lowers blood pressure by relaxing blood vessels, making it easier for the heart to pump blood. Clinical studies have shown that it reduces blood pressure in patients with hypertension and increases exercise tolerance in patients with chronic stable angina, demonstrating its effectiveness in managing these conditions.
What is Nicardipine?
Nicardipine is used to treat high blood pressure and control angina chest pain. It belongs to a class of medications called calcium channel blockers, which work by relaxing blood vessels, making it easier for the heart to pump blood. This increases the supply of blood and oxygen to the heart, helping to control chest pain.
Directions for Use
For how long do I take Nicardipine?
Nicardipine is typically used as a long-term treatment for managing high blood pressure and angina. The duration of use depends on the individual's medical condition and response to treatment. It is important to continue taking Nicardipine even if you feel well, and not to stop without consulting your doctor.
How do I take Nicardipine?
Regular Nicardipine capsules can be taken with or without food, while extended-release capsules should be taken with food but avoid high-fat meals. Discuss with your doctor about consuming grapefruit or grapefruit juice, as it may interact with the medication. Always follow your doctor's instructions regarding food restrictions.
How long does it take for Nicardipine to start working?
Nicardipine is absorbed quickly, with plasma levels detectable within 20 minutes and peak levels reached within 30 minutes to 2 hours after an oral dose. However, it may take a few days to achieve steady-state plasma levels and observe the full therapeutic effect. Always follow your doctor's instructions for optimal results.
How should I store Nicardipine?
Store Nicardipine in its original container, tightly closed, at room temperature, away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. For disposal, use a medicine take-back program if available, and avoid flushing it down the toilet.
What is the usual dose of Nicardipine?
For adults, the usual dose of Nicardipine is 20 to 40 mg taken three times daily. The dose may be adjusted based on the individual's response and medical condition. For children, the safety and efficacy of Nicardipine have not been established, so it is not typically prescribed for pediatric use. Always follow your doctor's instructions regarding dosage.
Warnings and Precautions
Can I take Nicardipine with other prescription drugs?
Nicardipine can interact with cimetidine, which may increase its plasma levels. It may also interact with cyclosporine and tacrolimus, leading to elevated levels of these drugs. Patients should inform their doctor about all medications they are taking to avoid potential interactions and adjust dosages accordingly.
Can Nicardipine be taken safely while breastfeeding?
Nicardipine is found in maternal milk in animal studies, so it is recommended that women who wish to breastfeed should not take this drug. Consult your doctor to discuss the risks and benefits and to explore alternative treatments if necessary.
Can Nicardipine be taken safely while pregnant?
Nicardipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant women, so it is important to consult your doctor to weigh the risks and benefits before using this medication during pregnancy.
Is it safe to drink alcohol while taking Nicardipine?
Drinking alcohol while taking Nicardipine can increase the risk of side effects such as dizziness and lightheadedness. Alcohol can also enhance the blood pressure-lowering effects of Nicardipine, which might lead to excessive lowering of blood pressure. It is advisable to limit alcohol consumption and discuss with your doctor if you plan to drink alcohol while on this medication.
Is it safe to exercise while taking Nicardipine?
Nicardipine does not inherently limit the ability to exercise. However, because it can cause dizziness or lightheadedness, it is important to be cautious when engaging in physical activities. If you experience these side effects, it may be best to avoid strenuous exercise until you have discussed it with your doctor.
Is Nicardipine safe for the elderly?
For elderly patients, it is important to start Nicardipine at the lower end of the dosing range due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Regular monitoring of blood pressure and any side effects is recommended to ensure safe use.
Who should avoid taking Nicardipine?
Nicardipine is contraindicated in patients with hypersensitivity to the drug and those with advanced aortic stenosis. It should be used cautiously in patients with heart failure, liver, or kidney disease. Patients should be monitored for increased angina, and abrupt withdrawal of beta-blockers should be avoided. Always consult your doctor for personalized advice.
