Nefopam + Paracetamol
Find more information about this combination medication at the webpages for nefopam and paracetamol
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Nefopam is used for moderate to severe pain, such as after surgery or injury. Paracetamol is used for mild to moderate pain and fever, like headaches or colds. Together, they provide comprehensive pain relief for various conditions.
Nefopam blocks the reuptake of neurotransmitters, which are chemicals that transmit signals in the brain, to reduce pain perception. Paracetamol inhibits the production of prostaglandins, which are chemicals that cause pain and inflammation, to relieve pain and reduce fever.
Nefopam is usually taken as 30 mg three times a day. Paracetamol is taken in doses of 500 mg to 1000 mg every 4 to 6 hours, not exceeding 4000 mg in 24 hours. Both are taken orally, which means by mouth.
Nefopam can cause nausea, dizziness, and sweating. In some cases, it may lead to confusion or hallucinations, which are seeing or hearing things that aren't there. Paracetamol is generally well-tolerated but can cause liver damage in high doses.
Nefopam should not be used by those with a history of seizures or severe liver or kidney disease. Paracetamol should be used cautiously in individuals with liver disease. Both should be used with caution in those with alcohol dependency.
Indications and Purpose
How does combination of Nefopam and Paracetamol work?
Nefopam is a pain reliever which works by blocking the reuptake of certain neurotransmitters, which are chemicals in the brain that transmit signals. This action helps to reduce the perception of pain. It is unique because it does not belong to the opioid class of painkillers and does not have anti-inflammatory properties. Paracetamol, also known as acetaminophen, is another pain reliever which works by inhibiting the production of prostaglandins, which are chemicals that promote inflammation, pain, and fever. It is unique because it is often used to reduce fever and has minimal anti-inflammatory effects. Both Nefopam and Paracetamol are used to relieve pain, but they work in different ways. They are both non-opioid painkillers, meaning they do not carry the risk of addiction associated with opioids. They are often used when other pain relief methods are not suitable.
How effective is combination of Nefopam and Paracetamol?
Nefopam and Paracetamol are both effective pain relievers, but they work in different ways. Nefopam is a non-opioid painkiller which means it doesn't belong to the opioid class of drugs, and it works by affecting the way the brain perceives pain. It's often used for moderate to severe pain and is unique because it doesn't have anti-inflammatory properties, which means it doesn't reduce swelling. Paracetamol, on the other hand, is a common pain reliever and fever reducer which is often used for mild to moderate pain. It works by blocking the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. Both Nefopam and Paracetamol are used to manage pain, but they do not have the same mechanism of action. They are often used together to provide a more comprehensive approach to pain management, as they can complement each other's effects without increasing the risk of side effects.
Directions for Use
What is the usual dose of combination of Nefopam and Paracetamol?
The usual adult daily dose for Nefopam, which is a pain reliever used to treat moderate pain, is typically 30 mg taken three times a day. For Paracetamol, which is another pain reliever used to reduce fever and relieve mild to moderate pain, the usual adult dose is 500 mg to 1000 mg every 4 to 6 hours, not exceeding 4000 mg in a day. Nefopam is unique because it works by affecting the way the brain and nervous system respond to pain. Paracetamol, on the other hand, is unique in its ability to reduce fever and is often used for headaches and minor aches. Both medicines share the common attribute of being used to relieve pain, but they work in different ways and are used for different types of pain. It's important to follow the recommended doses to avoid side effects.
How does one take combination of Nefopam and Paracetamol?
Nefopam, which is a pain reliever used to treat moderate pain, can be taken with or without food. However, taking it with food may help reduce stomach upset. Paracetamol, which is also a pain reliever used for mild to moderate pain and fever, can be taken with or without food as well. There are no specific food restrictions for either Nefopam or Paracetamol, but it's always a good idea to follow any additional advice from your healthcare provider. Both medicines share the common attribute of being pain relievers, but they work in different ways. Nefopam is not an anti-inflammatory, while Paracetamol is often used for its fever-reducing properties. Always use these medications as directed by a healthcare professional to ensure safety and effectiveness.
For how long is combination of Nefopam and Paracetamol taken?
Nefopam is typically used for short-term relief of moderate pain, which means it is not usually taken for long periods. It works by blocking pain signals in the brain. Paracetamol, on the other hand, is often used for both short-term and long-term pain relief, such as headaches or chronic conditions like arthritis, which refers to inflammation of the joints. It reduces pain and fever by affecting the chemicals in the brain. Both medicines are used to relieve pain, but they work in different ways. Nefopam is not an anti-inflammatory, which means it does not reduce swelling, while paracetamol can help reduce fever. Both are generally taken orally, which means by mouth, and are available in tablet form. It's important to follow the prescribed duration and dosage for each to avoid side effects.
How long does it take for combination of Nefopam and Paracetamol to work?
The combination medicine typically starts working within 30 minutes to an hour. This is because it contains two active ingredients: ibuprofen and pseudoephedrine. Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID), helps reduce pain and inflammation. It usually begins to relieve pain within 20 to 30 minutes after taking it. Pseudoephedrine, which is a decongestant, works by narrowing the blood vessels in the nasal passages to reduce swelling and congestion. It generally starts to work within 30 minutes. Both medicines are absorbed quickly into the bloodstream, which is why they start working relatively fast. However, the exact time can vary depending on individual factors like metabolism and whether the medicine is taken with food. Together, they provide relief from symptoms like headache, fever, and nasal congestion.
Warnings and Precautions
Are there harms and risks from taking combination of Nefopam and Paracetamol?
Nefopam and Paracetamol are both used to relieve pain, but they have different side effects and attributes. Nefopam can cause side effects like nausea, dry mouth, and dizziness, which refers to feeling lightheaded or unsteady. It may also lead to more serious effects like confusion or hallucinations, which are seeing or hearing things that aren't there. Paracetamol is generally well-tolerated, but in rare cases, it can cause liver damage, which is harm to the liver, especially if taken in high doses. Both medicines share the common attribute of being pain relievers, but they work differently in the body. Nefopam is unique in that it is not an anti-inflammatory, which means it doesn't reduce swelling, while Paracetamol is known for being gentle on the stomach. It's important to use both medications as directed to avoid adverse effects.
Can I take combination of Nefopam and Paracetamol with other prescription drugs?
Nefopam, which is a pain reliever, can interact with other medications that affect the central nervous system, which includes the brain and spinal cord. This can lead to increased side effects like drowsiness or dizziness. It is important to avoid alcohol and other sedatives while taking Nefopam. Paracetamol, which is also a pain reliever and fever reducer, is generally safe but can cause liver damage if taken in high doses or with other medications that affect the liver. Both Nefopam and Paracetamol are used to relieve pain, but they work in different ways. Nefopam is not an anti-inflammatory, while Paracetamol can reduce fever. They do not have significant interactions with each other, but caution is advised when combining them with other medications. Always consult a healthcare provider before taking these medications together or with other drugs.
Can I take combination of Nefopam and Paracetamol if I am pregnant?
Nefopam is a pain reliever which is not commonly recommended during pregnancy due to limited information on its safety. It works by affecting the way the brain and nervous system respond to pain. Paracetamol, also a pain reliever, is generally considered safe during pregnancy when used at recommended doses. It helps reduce fever and relieve mild to moderate pain. Both Nefopam and Paracetamol are used to manage pain, but they work in different ways. Paracetamol is often preferred during pregnancy because it has a well-established safety profile. Nefopam, on the other hand, lacks sufficient data to confirm its safety for pregnant women. In summary, while both medications are used for pain relief, Paracetamol is typically the safer choice during pregnancy, whereas Nefopam should be used with caution and under medical advice.
Can I take combination of Nefopam and Paracetamol while breastfeeding?
Nefopam, which is a pain reliever, is not well-studied for use during breastfeeding. It is generally advised to avoid it unless absolutely necessary, as its effects on a nursing infant are not well known. Paracetamol, which is also a pain reliever, is considered safe for use during breastfeeding. It is commonly used to treat mild to moderate pain and fever. Both Nefopam and Paracetamol are used to relieve pain, but Paracetamol is more widely recommended for breastfeeding mothers due to its established safety profile. While Paracetamol is known to pass into breast milk in small amounts, it is not expected to harm a nursing baby. In contrast, the lack of data on Nefopam makes it a less favorable choice for breastfeeding mothers. Always consult a healthcare provider before taking any medication while breastfeeding.
Who should avoid taking combination of Nefopam and Paracetamol?
Nefopam, which is a pain reliever, should not be used by people with a history of convulsions, which are sudden, uncontrolled electrical disturbances in the brain. It can also cause side effects like dizziness and confusion, so it’s important to avoid driving or operating machinery until you know how it affects you. Paracetamol, which is another pain reliever, should be used with caution in people with liver problems, as it can cause liver damage if taken in high doses or for a long time. Both Nefopam and Paracetamol should not be mixed with alcohol, as this can increase the risk of side effects. It’s also important to follow the recommended dosage for both medicines to avoid potential harm. Always consult a healthcare professional before starting or combining these medications to ensure they are safe for your specific health conditions.
