Naratriptan
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Serotonin-1b and Serotonin-1d Receptor Agonist
Controlled Drug Substance
No
Naratriptan
Summary
Naratriptan is used to treat acute migraine headaches in adults. It can be used for migraines with or without aura. It's not used to prevent migraines or treat other types of headaches.
Naratriptan works by binding to serotonin receptors in the brain, specifically the 5HT1B/1D receptors. This leads to the narrowing of blood vessels around the brain and inhibits the release of substances that cause migraine symptoms.
For adults, the usual dose of Naratriptan is 1 mg or 2.5 mg taken orally at the first sign of a migraine. If the migraine returns, a second dose may be taken after 4 hours, with a maximum of 5 mg in a 24-hour period.
Common side effects of Naratriptan include nausea, dizziness, and drowsiness. Serious adverse effects can include chest pain, shortness of breath, and signs of a stroke. If serious side effects occur, seek immediate medical attention.
Naratriptan is contraindicated in patients with a history of heart disease, stroke, uncontrolled hypertension, or severe renal or hepatic impairment. It should not be used with other triptans or ergot-type medications within 24 hours. Patients should be aware of the risk of serious cardiovascular events and seek medical attention if symptoms occur.
Indications and Purpose
How does Naratriptan work?
Naratriptan works by narrowing blood vessels in the brain, which helps relieve migraine symptoms. During a migraine, blood vessels can widen, causing pain and other symptoms. Naratriptan reverses this process, reducing the headache and associated symptoms like nausea and sensitivity to light or sound. This action helps provide relief from migraines. It is important to take Naratriptan as soon as symptoms appear for the best effect.
Is Naratriptan effective?
Naratriptan is effective for treating migraines. It works by narrowing blood vessels in the brain, which helps relieve headache pain and other migraine symptoms. Clinical studies show that Naratriptan can significantly reduce migraine symptoms within a few hours. It is important to take it as soon as migraine symptoms appear for the best results. If you find it is not effective, consult your doctor for alternative treatments.
What is Naratriptan?
Naratriptan is a medication used to treat migraines. It belongs to a class of drugs called triptans, which work by narrowing blood vessels in the brain to relieve headache pain and other migraine symptoms. Naratriptan is taken as soon as migraine symptoms appear and can help reduce the severity and duration of the attack. It is not used for preventing migraines or treating other types of headaches.
Directions for Use
For how long do I take Naratriptan?
Naratriptan is used for short-term relief of migraine symptoms and is taken as needed. You take it when you notice migraine symptoms starting. It is not used for long-term or daily treatment. If you have frequent migraines, your doctor may suggest a preventive treatment plan. Always follow your doctor's advice on how to use Naratriptan for your specific needs.
How do I dispose of Naratriptan?
Dispose of Naratriptan by taking it to a drug take-back program or collection site at a pharmacy or hospital. This ensures the medication is disposed of safely and does not harm people or the environment. If a take-back program is not available, you can throw it in the trash at home. Mix it with something undesirable, like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Naratriptan?
Take Naratriptan as soon as you notice migraine symptoms. The usual dose is one tablet, which can be taken with or without food. If your migraine returns, you can take a second dose after four hours, but do not exceed two doses in 24 hours. Naratriptan tablets should not be crushed. If you miss a dose, take it as soon as you remember, but do not double up on doses. Always follow your doctor's specific instructions regarding dosage and timing.
How long does it take for Naratriptan to start working?
Naratriptan typically starts working within one to two hours after taking it. The time it takes to achieve full relief can vary depending on individual factors, such as the severity of the migraine and how quickly the medication is taken after symptoms begin. For best results, take Naratriptan as soon as you notice migraine symptoms. If you have concerns about how quickly it works, discuss them with your doctor.
How should I store Naratriptan?
Store Naratriptan at room temperature, away from moisture and light. Keep it in its original packaging until you are ready to take it. Do not store it in the bathroom, where humidity can affect the medication. Ensure it is out of reach of children and pets. Check the expiration date regularly and dispose of any expired medication properly.
What is the usual dose of Naratriptan?
The usual starting dose of Naratriptan for adults is 2.5 mg taken as soon as migraine symptoms appear. If the migraine returns, a second dose can be taken after four hours, but do not exceed 5 mg in 24 hours. Dose adjustments may be necessary for special populations, such as the elderly or those with liver or kidney issues. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can I take Naratriptan with other prescription drugs?
Naratriptan can interact with certain medications, increasing the risk of side effects. It should not be used with other triptans or ergotamine-containing drugs, as this can lead to serious cardiovascular effects. Combining Naratriptan with SSRIs or SNRIs, which are antidepressants, may increase the risk of serotonin syndrome, a potentially life-threatening condition. Always inform your doctor of all medications you are taking to avoid harmful interactions.
Can Naratriptan be taken safely while breastfeeding?
The safety of Naratriptan while breastfeeding is not well-established. It is not known if Naratriptan is excreted into human breast milk. If you are breastfeeding or planning to breastfeed, discuss with your doctor whether to use Naratriptan. They can help weigh the potential risks and benefits and suggest alternative treatments if necessary to ensure the safety of your baby.
Can Naratriptan be taken safely while pregnant?
The safety of Naratriptan during pregnancy is not well-established. Limited evidence is available, and its use should be discussed with a doctor. Animal studies have not shown harm, but human data is lacking. If you are pregnant or planning to become pregnant, talk with your doctor about the safest way to manage migraines. They can help create a treatment plan that protects both you and your baby.
Does Naratriptan have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Naratriptan include dizziness, drowsiness, and nausea. These effects are usually mild. Serious side effects, like chest pain or allergic reactions, are rare but require immediate medical attention. If you experience any new or worsening symptoms, contact your doctor. They can help determine if these are related to Naratriptan and advise on the best course of action.
Does Naratriptan have any safety warnings?
Yes, Naratriptan has safety warnings. It should not be used by people with certain heart conditions, as it can cause serious cardiovascular side effects. If you experience chest pain, shortness of breath, or any signs of an allergic reaction, seek medical help immediately. Not adhering to these warnings can lead to severe health risks. Always discuss your medical history with your doctor before taking Naratriptan.
Is it safe to drink alcohol while taking Naratriptan?
It's best to avoid alcohol while taking Naratriptan. Alcohol can worsen migraine symptoms and may increase the risk of side effects like dizziness or drowsiness. If you choose to drink, limit your alcohol intake and be aware of how your body responds. If you experience any unusual symptoms, talk with your doctor. They can provide personalized advice based on your health situation.
Is it safe to exercise while taking Naratriptan?
You can exercise while taking Naratriptan, but be cautious. Some people may experience dizziness or drowsiness as side effects, which could affect exercise capacity. If you feel dizzy or lightheaded, avoid strenuous activities or high-impact sports. Listen to your body and rest if needed. Staying hydrated is important, especially during physical activity. If you have concerns about exercising while on Naratriptan, consult your doctor.
Is it safe to stop Naratriptan?
Naratriptan is used for short-term relief of migraine symptoms and is not typically taken on a regular schedule. You can stop taking it once your migraine symptoms are relieved. There are no withdrawal symptoms associated with stopping Naratriptan. However, if you have frequent migraines, consult your doctor for a long-term management plan. Always follow your doctor's advice regarding medication use.
Is Naratriptan addictive?
Naratriptan is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms. Naratriptan works by narrowing blood vessels in the brain to relieve migraine symptoms. This mechanism does not affect brain chemistry in a way that leads to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Naratriptan safe for the elderly?
Elderly individuals may be more sensitive to the side effects of Naratriptan, such as dizziness or increased blood pressure. It's important for older adults to use this medication under close medical supervision. The doctor may adjust the dose or monitor for any adverse effects more frequently. Always discuss your health conditions and medications with your doctor to ensure Naratriptan is safe for you.
What are the most common side effects of Naratriptan?
Side effects are unwanted reactions to a medication. Common side effects of Naratriptan include dizziness, drowsiness, and nausea. These occur in a small percentage of users and are usually mild. If you experience these side effects, they might be temporary or unrelated to the medication. Always talk with your doctor if you notice new symptoms after starting Naratriptan.
Who should avoid taking Naratriptan?
Naratriptan should not be used by people with certain heart conditions, such as coronary artery disease, which is a narrowing of the blood vessels that supply the heart. It is also contraindicated in people with uncontrolled high blood pressure. These conditions increase the risk of serious cardiovascular side effects. Always inform your doctor of your medical history before taking Naratriptan to ensure it is safe for you.
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