Naldemedine
Constipation
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Opioid Antagonist
Controlled Drug Substance
No
Naldemedine
Summary
Naldemedine is used to treat constipation caused by opioid medications in adults with chronic non-cancer pain.
Naldemedine works by blocking the effects of opioids on the gastrointestinal tract, without affecting pain relief. This helps to alleviate constipation.
Naldemedine is typically taken orally once a day. The usual daily dose for adults is 0.2 mg, with or without food.
Common side effects of Naldemedine include abdominal pain, diarrhea, nausea, and vomiting. Serious effects include gastrointestinal perforation and opioid withdrawal symptoms.
Naldemedine should not be used if you have gastrointestinal obstruction or a history of hypersensitivity to the drug. It may interact with certain medications and herbal products, so inform your healthcare provider about all supplements you are taking. It's not recommended for breastfeeding women and its safety in pregnancy is not established.
Indications and Purpose
How does Naldemedine work?
Naldemedine works by blocking opioid receptors in the gut. Normally, opioids bind to these receptors and slow down bowel movements, causing constipation. Naldemedine prevents this binding, allowing the gut to function normally. Think of it like removing a roadblock, letting traffic flow smoothly again. This helps relieve constipation without affecting pain relief from opioids.
Is Naldemedine effective?
Naldemedine is effective for treating opioid-induced constipation, which is constipation caused by opioid pain medications. It works by blocking opioid receptors in the gut, helping to restore normal bowel function. Clinical studies show that Naldemedine significantly improves bowel movement frequency and relieves constipation symptoms in people taking opioids. This makes it a valuable option for managing constipation in patients using opioid medications.
What is Naldemedine?
Naldemedine is a medication used to treat opioid-induced constipation, which is constipation caused by opioid pain medications. It belongs to a class of drugs called peripherally acting mu-opioid receptor antagonists. Naldemedine works by blocking opioid receptors in the gut, helping to restore normal bowel function without affecting pain relief from opioids.
Directions for Use
For how long do I take Naldemedine?
Naldemedine is usually used for short-term relief of opioid-induced constipation. The duration of use depends on your individual needs and response to treatment. Always follow your doctor's instructions regarding how long to take Naldemedine. If you have concerns about the duration of use, talk with your doctor for guidance.
How do I dispose of Naldemedine?
If you can, bring unused Naldemedine to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Naldemedine?
Take Naldemedine as prescribed by your doctor, usually once daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Naldemedine to start working?
Naldemedine starts working within a few hours after taking it. You may notice an improvement in bowel movements within a day. The full therapeutic effect can vary depending on individual factors like your overall health and response to the medication. If you don't see improvement, talk with your doctor for further guidance.
How should I store Naldemedine?
Store Naldemedine at room temperature, away from moisture and light. Keep it in its original container and out of reach of children. Do not store it in the bathroom, where humidity can affect the medication. Always check the expiration date and properly dispose of any unused or expired medication.
What is the usual dose of Naldemedine?
The usual dose of Naldemedine for adults is 0.2 mg once daily. It can be taken with or without food. Always follow your doctor's specific dosing instructions. If you have any concerns or experience side effects, consult your doctor for advice. Your doctor may adjust your dose based on your health needs.
Warnings and Precautions
Can I take Naldemedine with other prescription drugs?
Naldemedine may interact with other medications that affect the gastrointestinal tract. It's important to inform your doctor about all the medications you are taking to avoid potential interactions. Your doctor can help determine if any of your medications might interact with Naldemedine and adjust your treatment plan accordingly.
Can Naldemedine be taken safely while breastfeeding?
The safety of Naldemedine while breastfeeding is not well-established. It's unclear if this medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that allows you to nurse your baby safely.
Can Naldemedine be taken safely while pregnant?
The safety of Naldemedine during pregnancy is not well-established. There is limited information on its use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Does Naldemedine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Naldemedine include abdominal pain, diarrhea, and nausea. These effects are usually mild. Serious adverse effects, like gastrointestinal perforation, are rare but require immediate medical attention. If you experience any new or worsening symptoms while taking Naldemedine, contact your doctor. They can help determine if the symptoms are related to the medication.
Does Naldemedine have any safety warnings?
Naldemedine has safety warnings you should be aware of. It can cause gastrointestinal perforation, which is a hole in the wall of the stomach or intestines. If you experience severe abdominal pain, fever, or chills, seek medical help immediately. Naldemedine may also cause withdrawal symptoms in people who are physically dependent on opioids. Always follow your doctor's instructions and report any unusual symptoms.
Is it safe to drink alcohol while taking Naldemedine?
It's best to avoid alcohol while taking Naldemedine. Alcohol can increase the risk of gastrointestinal side effects like nausea and diarrhea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for any worsening symptoms. Talk with your doctor about alcohol use while taking Naldemedine to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Naldemedine?
You can exercise while taking Naldemedine, but keep a few things in mind. This medication can cause gastrointestinal side effects like diarrhea, which might affect your comfort during exercise. To exercise safely, stay hydrated and listen to your body. If you experience any discomfort or unusual symptoms, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Naldemedine.
Is it safe to stop Naldemedine?
Naldemedine is usually used for short-term relief of opioid-induced constipation. Stopping it suddenly is generally safe, but your constipation may return. If you have concerns about stopping Naldemedine, talk with your doctor. They can provide guidance on managing your symptoms and suggest alternative treatments if needed.
Is Naldemedine addictive?
Naldemedine is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Naldemedine works by blocking opioid receptors in the gut to relieve constipation without affecting brain chemistry. This mechanism doesn't lead to addiction. If you have concerns about medication dependence, you can feel confident that Naldemedine doesn't carry this risk.
Is Naldemedine safe for the elderly?
Elderly individuals may be more sensitive to the effects of Naldemedine, especially gastrointestinal side effects like diarrhea. It's important for older adults to be monitored closely while taking this medication. If you are elderly and taking Naldemedine, talk with your doctor about any concerns. They can help ensure your treatment is safe and effective.
What are the most common side effects of Naldemedine?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Naldemedine include abdominal pain, diarrhea, and nausea. These effects are usually mild and may go away on their own. If you notice new symptoms after starting Naldemedine, they might be temporary or unrelated to the medication. Talk with your doctor if you have concerns about side effects.
Who should avoid taking Naldemedine?
Don't take Naldemedine if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Naldemedine is not recommended for people with known or suspected gastrointestinal obstruction, which is a blockage in the intestines. Always consult your doctor about these concerns before starting Naldemedine.
