Nadolol
Hypertension, Angina Pectoris ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Beta-Adrenergic Blocker
Controlled Drug Substance
No
Nadolol
Summary
Nadolol is primarily used to treat high blood pressure and prevent chest pain, known as angina. It can also be used to prevent migraine headaches and manage certain types of irregular heartbeats.
Nadolol is a non-selective beta-blocker. It works by blocking beta-adrenergic receptors in the heart and blood vessels, reducing heart rate, cardiac output, and blood pressure. This helps improve blood flow and decrease the heart's oxygen demand.
The usual daily dose of Nadolol for adults with hypertension or angina is between 40 mg to 320 mg, taken once daily. It's not typically recommended for children as its safety and effectiveness in pediatric patients have not been established.
Common side effects of Nadolol include dizziness, lightheadedness, and excessive tiredness. Serious but uncommon side effects include shortness of breath, swelling of extremities, unusual weight gain, fainting, chest pain, and slow or irregular heartbeat.
Nadolol is contraindicated in patients with bronchial asthma, sinus bradycardia, greater than first-degree heart block, cardiogenic shock, and overt cardiac failure. It should be used with caution in patients with renal impairment, diabetes, and those undergoing major surgery. Abrupt discontinuation can exacerbate angina or cause myocardial infarction.
Indications and Purpose
How does Nadolol work?
Nadolol is a nonselective beta-adrenergic receptor blocker that works by inhibiting the action of certain natural chemicals in the body, such as epinephrine, on the heart and blood vessels. This action results in a reduction of heart rate, cardiac output, and blood pressure, which helps to improve blood flow and decrease the workload on the heart. Nadolol does not have intrinsic sympathomimetic activity and is excreted unchanged by the kidneys.
Is Nadolol effective?
Nadolol is a nonselective beta-adrenergic receptor blocking agent that has been shown in clinical studies to effectively reduce heart rate, cardiac output, and blood pressure. It is used for the long-term management of angina pectoris and hypertension. The effectiveness of Nadolol in lowering blood pressure and managing angina has been demonstrated in controlled clinical studies, making it a reliable option for these conditions.
What is Nadolol?
Nadolol is a beta-blocker used to treat high blood pressure and prevent angina (chest pain). It works by relaxing blood vessels and slowing the heart rate, which improves blood flow and decreases blood pressure. Nadolol is also sometimes used to prevent migraine headaches. It is important to take Nadolol as prescribed and not to stop it suddenly without consulting a doctor.
Directions for Use
For how long do I take Nadolol?
Nadolol is typically used for long-term management of conditions like hypertension and angina. It is important to continue taking Nadolol even if you feel well, as it controls the condition but does not cure it. The duration of use should be determined by your doctor based on your specific health needs.
How do I take Nadolol?
Nadolol should be taken once a day, with or without food, at the same time each day to help you remember. There are no specific food restrictions while taking Nadolol, but it is important to follow a healthy lifestyle, including a diet low in fat and salt, to help control blood pressure. Always follow your doctor's instructions regarding dosage and lifestyle changes.
How long does it take for Nadolol to start working?
Nadolol begins to work within a few hours of taking a dose, with peak serum concentrations usually occurring three to four hours after oral administration. However, it may take several days to weeks to see the full effect on blood pressure or angina symptoms. It is important to continue taking Nadolol as prescribed and attend regular follow-up appointments to monitor its effectiveness.
How should I store Nadolol?
Nadolol should be stored at room temperature, between 15°C to 30°C (59°F to 86°F), and protected from light. Keep the medication in its original container, tightly closed, and out of reach of children. Avoid storing it in the bathroom to prevent exposure to excess heat and moisture. For disposal, use a medicine take-back program to ensure it is not consumed by pets, children, or others.
What is the usual dose of Nadolol?
For adults, the usual initial dose of Nadolol for hypertension is 40 mg once daily, which can be increased in 40 to 80 mg increments until the desired blood pressure is achieved. For angina, the initial dose is also 40 mg once daily, with a maintenance dose typically between 40 to 80 mg daily. The maximum dose for both conditions can go up to 240 or 320 mg daily. Nadolol is not recommended for use in children as its safety and effectiveness have not been established in pediatric patients.
Warnings and Precautions
Can I take Nadolol with other prescription drugs?
Nadolol can interact with several medications, including other beta-blockers, digitalis glycosides, and antidiabetic drugs. It may exaggerate the hypotension induced by general anesthetics and affect blood sugar levels. Patients with a history of severe allergic reactions may be more reactive to allergens while taking Nadolol. It is important to inform your doctor of all medications you are taking to avoid potential interactions.
Can Nadolol be taken safely while breastfeeding?
Nadolol is excreted in human milk, and there is potential for adverse effects in nursing infants. Therefore, a decision should be made whether to discontinue nursing or to discontinue the medication, taking into account the importance of Nadolol to the mother. If you are breastfeeding or planning to breastfeed, consult your doctor for personalized advice.
Can Nadolol be taken safely while pregnant?
Nadolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant women, but animal studies have shown evidence of embryo- and fetotoxicity in rabbits. If you are pregnant or planning to become pregnant, consult your doctor to weigh the risks and benefits of using Nadolol.
Is it safe to exercise while taking Nadolol?
Nadolol can affect your ability to exercise by slowing your heart rate and reducing your heart's workload. This may lead to fatigue or reduced exercise tolerance. If you notice significant limitations in your ability to exercise, it is important to discuss this with your doctor. They can provide guidance on how to safely incorporate physical activity into your routine while taking Nadolol.
Is Nadolol safe for the elderly?
Elderly patients may require careful monitoring and dosage adjustments when taking Nadolol, especially if they have impaired renal function. It is important for elderly patients to follow their doctor's instructions closely and report any unusual symptoms or side effects. Regular check-ups are recommended to ensure the medication is working effectively and safely.
Who should avoid taking Nadolol?
Nadolol is contraindicated in patients with bronchial asthma, sinus bradycardia, greater than first-degree conduction block, cardiogenic shock, and overt cardiac failure. It should be used with caution in patients with impaired renal function, diabetes, and those with a history of severe allergies. Abrupt discontinuation can exacerbate angina or cause myocardial infarction. Patients should be monitored for signs of heart failure and advised against sudden withdrawal of the medication.
