Mitotane
Adrenocortical Carcinoma, Cushing Syndrome
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
NA
Controlled Drug Substance
No
Mitotane
Summary
Mitotane is used to treat adrenal cancer, which is a type of cancer that starts in the adrenal glands. These glands are located on top of each kidney and produce hormones that regulate various body functions.
Mitotane works by reducing the production of hormones from the adrenal glands, which can help slow the growth of cancer cells. This action helps control the symptoms of adrenal cancer and can improve survival rates.
The usual starting dose of Mitotane for adults is 2 to 6 grams per day, divided into two or three doses. The maximum recommended dose is 16 grams per day. It is taken orally, usually with food to reduce stomach upset.
Common side effects of Mitotane include fatigue, nausea, vomiting, and diarrhea. These effects can vary in severity from mild to moderate. It can also cause mood changes, difficulty sleeping, and decreased appetite.
Mitotane should not be used if you are allergic to it or its ingredients. It is not recommended for pregnant or breastfeeding women. Caution is needed for people with liver problems, as Mitotane can affect liver function.
Indications and Purpose
How does Mitotane work?
Mitotane works by affecting the adrenal glands, which are small glands located on top of each kidney. It reduces the production of hormones from these glands, which can help slow the growth of cancer cells. Think of it like turning down the volume on a radio. By reducing hormone production, Mitotane helps control the symptoms of adrenal cancer and can improve survival rates. This medication is effective for people with adrenal cancer and is an important part of their treatment plan. Always follow your doctor's instructions when taking Mitotane.
Is Mitotane effective?
Mitotane is effective for treating adrenal cancer, which is a type of cancer that starts in the adrenal glands. It works by reducing the production of hormones from the adrenal glands, which can help slow the growth of cancer cells. Clinical studies show that Mitotane can improve survival rates and reduce tumor size in some patients. However, its effectiveness can vary depending on the individual and the stage of cancer. Regular monitoring and communication with your healthcare provider are important to assess the effectiveness of Mitotane in your treatment plan.
What is Mitotane?
Mitotane is a medication used to treat adrenal cancer, which is a type of cancer that starts in the adrenal glands. It belongs to a class of drugs called antineoplastics, which are medications that help stop the growth of cancer cells. Mitotane works by reducing the production of hormones from the adrenal glands, which can help slow the growth of cancer cells. It's primarily used for adrenal cancer, but it may also be used for other conditions as determined by your doctor. Always follow your doctor's instructions when taking Mitotane.
Directions for Use
For how long do I take Mitotane?
Mitotane is usually a long-term medication for managing adrenal cancer, which is a type of cancer that starts in the adrenal glands. You'll typically take Mitotane every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Mitotane treatment.
How do I dispose of Mitotane?
To dispose of Mitotane, bring unused medicine to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. First, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. Always follow local guidelines for medication disposal.
How do I take Mitotane?
Take Mitotane exactly as your doctor prescribes. It's usually taken two to three times a day with food to help reduce stomach upset. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. Avoid alcohol while taking Mitotane, as it can increase side effects. Always follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
How long does it take for Mitotane to start working?
Mitotane starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to months to appear. The time it takes to see results can vary depending on individual factors like your overall health and the stage of your condition. Regular monitoring and communication with your healthcare provider are important to assess the effectiveness of Mitotane in your treatment plan. Always take Mitotane exactly as prescribed for the best results and talk with your doctor about any concerns you have regarding its effectiveness.
How should I store Mitotane?
Store Mitotane at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Do not store it in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store Mitotane out of children's reach to prevent accidental swallowing. Remember to check the expiration date regularly and properly dispose of any unused or expired medication. Following these storage guidelines helps maintain the effectiveness and safety of Mitotane.
What is the usual dose of Mitotane?
The usual starting dose of Mitotane for adults is 2 to 6 grams per day, divided into two or three doses. Your doctor may adjust the dose based on your response and tolerance. The maximum recommended dose is 16 grams per day. Dose adjustments may be necessary for elderly patients or those with liver problems. Always follow your doctor's specific dosing instructions for your health needs. It's important to take Mitotane exactly as prescribed to manage your condition effectively.
Warnings and Precautions
Can I take Mitotane with other prescription drugs?
Mitotane can interact with several prescription drugs. It can increase the metabolism of certain medications, reducing their effectiveness. For example, it may affect blood thinners like warfarin, which are medications that help prevent blood clots, and seizure medications like phenytoin. These interactions can increase the risk of adverse effects or reduce the effectiveness of the medications. Always inform your doctor about all the medications you are taking to prevent potential interactions. Your doctor can adjust your treatment plan to ensure safe and effective use of Mitotane.
Can Mitotane be taken safely while breastfeeding?
Mitotane is not recommended while breastfeeding. There is limited information on whether this medication passes into human breast milk, but it may pose risks to the developing baby. The medication could affect the baby's adrenal glands, which are small glands located on top of each kidney. If you're taking Mitotane and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Always inform your healthcare provider about your breastfeeding plans while on Mitotane.
Can Mitotane be taken safely while pregnant?
Mitotane is not recommended during pregnancy. It can harm the developing baby, especially in the later stages of pregnancy. There is limited information on the use of Mitotane in pregnant women, but animal studies suggest potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby. Always inform your healthcare provider if you become pregnant while taking Mitotane.
Does Mitotane have adverse effects?
Adverse effects are unwanted reactions that can occur with medication use. Mitotane can cause nausea, vomiting, and diarrhea, which are common adverse effects. These symptoms can be mild to moderate in severity. More serious effects include adrenal insufficiency, which is when your adrenal glands don't produce enough hormones, and liver problems. If you experience severe symptoms like extreme fatigue, dizziness, or abdominal pain, contact your doctor immediately. Always inform your healthcare provider about any new or worsening symptoms while taking Mitotane to ensure safe and effective treatment.
Does Mitotane have any safety warnings?
Yes, Mitotane has important safety warnings. It can cause adrenal insufficiency, which is when your adrenal glands don't produce enough hormones. This can lead to fatigue, weakness, and low blood pressure. Mitotane can also affect liver function, so regular monitoring is necessary. Not adhering to these warnings can result in serious health issues. If you experience symptoms like severe fatigue, dizziness, or abdominal pain, contact your doctor immediately. Always follow your doctor's advice and attend regular check-ups to ensure safe use of Mitotane.
Is it safe to drink alcohol while taking Mitotane?
It's best to avoid alcohol while taking Mitotane. Alcohol can increase the risk of liver problems, which is a concern with Mitotane use. Drinking alcohol may also worsen side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like severe fatigue or abdominal pain. These symptoms could indicate liver issues and require immediate medical attention. Talk with your doctor about alcohol use while taking Mitotane to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Mitotane?
You can exercise while taking Mitotane, but be cautious. This medication can cause fatigue and weakness, which might affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel tired or weak. It's important to stay hydrated, as Mitotane can cause nausea and vomiting, which may lead to dehydration. If you notice symptoms like dizziness or unusual fatigue during exercise, slow down or stop and rest. Always talk with your doctor about your exercise routine while taking Mitotane to ensure it's safe for your specific situation.
Is it safe to stop Mitotane?
Stopping Mitotane suddenly can cause serious problems. It's used long-term for conditions like adrenal cancer, which is a type of cancer that starts in the adrenal glands. Stopping it abruptly can lead to a rapid return of symptoms and worsen your condition. There are no specific withdrawal symptoms, but always talk with your doctor before stopping Mitotane. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Mitotane addictive?
Mitotane is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Mitotane works by affecting the adrenal glands, which are small glands located on top of each kidney, to reduce hormone production. This mechanism doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Mitotane doesn't carry this risk while managing your health condition.
Is Mitotane safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Mitotane. This is because they often have decreased liver and kidney function, which can affect how the body processes the medication. Mitotane can cause fatigue, dizziness, and liver problems, which may be more pronounced in older adults. Regular monitoring and communication with your healthcare provider are important to ensure safe use of Mitotane in the elderly. Your doctor may adjust the dose or suggest additional precautions to minimize risks and manage any side effects effectively.
What are the most common side effects of Mitotane?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Mitotane include nausea, vomiting, and diarrhea. These effects can vary from person to person and are usually mild to moderate in severity. If you notice new symptoms after starting Mitotane, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. Your doctor can help determine if the side effects are related to Mitotane and suggest ways to manage them.
Who should avoid taking Mitotane?
Mitotane has important contraindications. It should not be used if you are allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Mitotane is not recommended for pregnant or breastfeeding women, as it can harm the baby. Caution is needed for people with liver problems, as Mitotane can affect liver function. Always consult your doctor about these concerns and inform them of any medical conditions before starting Mitotane.
